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RISS 인기검색어
- 검색키워드
- 저자 : Jia Man-Ling (검색결과 4 건)
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Molybdenum trioxide impregnated carbon aerogel for gaseous elemental mercury removal
Yang Ling,Xiaokun Man,Wenbo Zhang,Daolei Wang,Jiang Wu,Qizhen Liu,Mingyan Gu,Yuyu Lin,Ping He,Tao Jia 한국화학공학회 2020 Korean Journal of Chemical Engineering Vol.37 No.4
A novel gaseous elemental mercury (Hg0) removal agent was successfully synthesized via impregnation method, by using molybdenum trioxide (MoO3) as the active component and carbon aerogel (CA) as the carrier. The as-prepared samples maintained a large specific surface area and excellent pore structure of the pure carbon aerogel, so that MoO3 was better dispersed to obtain enhanced Hg0 removal performance. The maximum efficiency of elemental mercury removal was about 74%, achieved by Mo/C500 sample at 300 oC, while it still had good ability (nearly 60%) in the range of 500-700 oC. The mechanism of mercury oxidation removal was also verified by DFT calculation. This work should help in developing suitable materials for thermocatalytic oxidation of elemental mercury, and also provide some theoretical basis and data support for full-scale application of heavy metal mercury pollution control in coalfired power plants.
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Ying-Jie Chen,Jia-Ying Wu,Yu-Yi Deng,Ying Wu,Xiao-Qi Wang,Amy Sze-man Li,Lut Yi Wong,Xiuqiong Fu,Zhi-Ling Yu,Chun Liang 고려인삼학회 2022 Journal of Ginseng Research Vol.46 No.3
Sorafenib is effective in treating hepatoma, but most patients develop resistance to it. STAT3signaling has been implicated in sorafenib resistance. Artesunate (ART) and 20(R)-ginsenoside Rg3 (Rg3)have anti-hepatoma effects and can inhibit STAT3 signaling in cancer cells. This study aimed to evaluatethe effects of Rg3 in combination with ART (Rg3-plus-ART) in overcoming sorafenib resistance, and toexamine the involvement of STAT3 signaling in these effects. Methods: Sorafenib-resistant HepG2 cells (HepG2-SR) were used to evaluate the in vitro anti-hepatomaeffects of Rg3-plus-ART. A HepG2-SR hepatoma-bearing BALB/c-nu/nu mouse model was used to assessthe in vivo anti-hepatoma effects of Rg3-plus-ART. CCK-8 assays and Annexin V-FITC/PI double stainingwere used to examine cell proliferation and apoptosis, respectively. Immunoblotting was employed toexamine protein levels. ROS generation was examined by measuring DCF-DA fluorescence. Results: Rg3-plus-ART synergistically reduced viability of, and evoked apoptosis in HepG2-SR cells, andsuppressed HepG2-SR tumor growth in mice. Mechanistic studies revealed that Rg3-plus-ART inhibitedactivation/phosphorylation of Src and STAT3 in HepG2-SR cultures and tumors. The combination alsodecreased the STAT3 nuclear level and induced ROS production in HepG2-SR cultures. Furthermore, overactivation of STAT3 or removal of ROS diminished the anti-proliferative effects of Rg3-plus-ART, andremoval of ROS diminished Rg3-plus-ART's inhibitory effects on STAT3 activation in HepG2-SR cells. Conclusions: Rg3-plus-ART overcomes sorafenib resistance in experimental models, and inhibition of Src/STAT3 signaling and modulation of ROS/STAT3 signaling contribute to the underlying mechanisms. Thisstudy provides a pharmacological basis for developing Rg3-plus-ART into a novel modality for treatingsorafenib-resistant hepatoma.
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Hydrodynamic characters of co-current operation for SO_2 absorption in a laboratory packed column
He Jie,,Tianjin University,Jia Man-Ling,Tan Chang-Bin 한국화학공학회 2011 Korean Journal of Chemical Engineering Vol.28 No.11
A co-current operation for SO_2 absorption by water was performed in a laboratory-scale packed column. The effects of L/V (liquid-gas ratio) and F (gas phase loading factor) on the SO_2 absorptivity were both investigated. The absorptivity for co-current increased with the increase of L/V and the percentage of absorptivity increase at higher L/V is larger. At lower F, in regular packing there is fluctuation of absorptivity with F increased, but in random packing there is not. With the increase of F, the absorption curve slowed down. It is proposed that in order to obtain a steady desulfurization efficiency, F factor in both kinds of packings should be higher than 4 kg^(0.5)/m^(0.5)s. For absorptivity, which could be reached by both co-current and counter-current, it is suggested that co-current is better because of the higher gas velocity.
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Sirolimus and Non-melanoma Skin Cancer Prevention after Kidney Transplantation: A Meta-analysis
Gu, Yu-Hong,Du, Jia-Xin,Ma, Man-Ling Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.9
Background: Whether sirolimus is useful in the prevention of non-melanoma skin cancer (NMSC) remains unclear and we therefore performed this meta-analysis of randomized controlled trials to test the hypothesis that Sirolimus-based immunosuppression is associated with a decrease in NMSC. Methods: The main outcomes were NMSC, squamous-cell carcinoma and basal-cell carcinoma. The pooled risk ratio (RR) with its 95% confidence interval (95%CI) were used to assess the effects. Results: 5 randomized trials involving a total of 1499 patients receiving kidney transplantation were included. Patients undergoing Sirolimus-based immunosuppression had much lower risk of NMSC (RR = 0.49, 95%CI 0.32-0.76, P = 0.001). Subgroup analyses by tumor type showed that Sirolimus-based immunosuppression significantly decreased risk of both squamous-cell carcinoma (RR = 0.58, 95%CI 0.43-0.78, P < 0.001) and basal-cell carcinoma (RR = 0.56, 95%CI 0.37-0.85, P = 0.006). The quality of evidence was high for NMSC, and moderate for squamous-cell carcinoma and basal-cell carcinoma. No evidence of publication bias was observed. Conclusion: High quality evidence suggests that Sirolimus-based immunosuppression decreases risk of non-melanoma skin cancer, and Sirolimus has an antitumoral effect among kidney-transplant recipients.
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