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Steering Epitaxial Alignment of Au, Pd, and AuPd Nanowire Arrays by Atom Flux Change
Yoo, Youngdong,Seo, Kwanyong,Han, Sol,Varadwaj, Kumar S. K.,Kim, Hyun You,Ryu, Ji Hoon,Lee, Hyuck Mo,Ahn, Jae Pyoung,Ihee, Hyotcherl,Kim, Bongsoo American Chemical Society 2010 Nano letters Vol.10 No.2
<P>We have synthesized epitaxial Au, Pd, and AuPd nanowire arrays in vertical or horizontal alignment on a c-cut sapphire substrate. We show that the vertical and horizontal nanowire arrays grow from half-octahedral seeds by the correlations of the geometry and orientation of seed crystals with those of as-grown nanowires. The alignment of nanowires can be steered by changing the atom flux. At low atom deposition flux vertical nanowires grow, while at high atom flux horizontal nanowires grow. Similar vertical/horizontal epitaxial growth is also demonstrated on SrTiO<SUB>3</SUB> substrates. This orientation-steering mechanism is visualized by molecular dynamics simulations.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/nalefd/2010/nalefd.2010.10.issue-2/nl903002x/production/images/medium/nl-2009-03002x_0001.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/nl903002x'>ACS Electronic Supporting Info</A></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/nl903002x'>ACS Electronic Supporting Info</A></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/nl903002x'>ACS Electronic Supporting Info</A></P>
Yoo Seung Soo,Lee Sunwoong,Choi Jin Eun,Hong Mi Jeong,Do Sook Kyung,Lee Jang Hyuck,Lee Won Kee,Park Ji Eun,Lee Yong Hoon,Choi Sun Ha,Seo Hyewon,Lee Jaehee,Lee Shin Yup,Cha Seung Ick,Kim Chang Ho,Kang 대한의학회 2023 Journal of Korean medical science Vol.38 No.45
Background: Neurogenic differentiation 1 (NeuroD1) is a representative small cell lung cancer (SCLC) transcription regulator involved in the carcinogenesis and behavior of SCLC. Histone modifications play an important role in transcription, and H3 lysine 4 trimethylation (H3K4me3) is primarily associated with promoter regions. Methods: We investigated the association between single nucleotide polymorphisms (SNPs) in NeuroD1 and H3K4me3 coincident regions, selected using ChIP sequencing (ChIP-seq), and the clinical outcomes of 261 patients with SCLC. Results: Among 230 SNPs, two were significantly associated with both the chemotherapy response and overall survival (OS) of patients with SCLC. RNF145 rs2043268A>G was associated with worse chemotherapy response and OS (under a recessive model, adjusted odds ratio [aOR], 0.50, 95% confidence interval [CI], 0.26–0.94, P = 0.031, and adjusted hazard ratio [aHR], 1.88, 95% CI, 1.38–2.57, P < 0.001). CINP rs762105A>G was also associated with worse chemotherapy response and OS (under a dominant model, aOR, 0.47, 95% CI, 0.23–0.99, P = 0.046, and aHR, 2.03, 95% CI, 1.47–2.82, P < 0.001). ChIP–quantitative polymerase chain reaction and luciferase assay confirmed that the two SNPs were located in the active promoter regions and influenced the promoter activity of each gene. Conclusion: To summarize, among SNPs selected using ChIP-seq in promoter regions with high peaks in both NeuroD1 and H3K4me3, RNF145 rs2043268A>G and CINP rs762105A>G were associated with clinical outcomes in patients with SCLC and also affected the promoter activity of each gene.
Hyuck-Soo Kim,Dae-Won Kang,Da-In Kim,Seul Lee,Sang-Won Park,Ji-Hyock Yoo,Won-Il Kim 한국토양비료학회 2016 한국토양비료학회지 Vol.49 No.5
The current study was carried out to investigate total and inorganic arsenic (As) concentrations in 112 rice samples (husked rice and polished rice) grown around the abandoned mining areas and to estimate the potential health risk through dietary intake of rice in Korea. Mean concentrations of total As in husked rice and polished rice were 0.23 and 0.13 mg kg<SUP>-1</SUP>, respectively. Also, average inorganic As concentrations in husked rice and polished rice were 0.09 and 0.05 mg kg<SUP>-1</SUP>, respectively. These levels are lower than the standard guideline value (0.2 mg kg<SUP>-1</SUP>) for inorganic As in polished rice recommended by Korea Ministry of Food and Drug Safety and Codex. For health risk assessment, the average values of cancer risk probability was 5.7×10<SUP>-5</SUP> which was less than the acceptable cancer risk of 10<SUP>-6</SUP>~10<SUP>-4</SUP> for regulatory purpose. Also, hazard quotient values were lower than 1.0. Therefore, these results demonstrated that human exposure to inorganic As through dietary intake of rice collected from abandoned mining areas might not cause adverse health effects.
Distribution of Arsenic Fraction in Soil Around Abandoned Mining Area and Uptake by Rice
Hyuck-Soo Kim,Woo-Ri Go,Dae-Won Kang,Ji-Hyock Yoo,Kye-Hoon Kim,Won-Il Kim 한국토양비료학회 2015 한국토양비료학회지 Vol.48 No.5
Arsenic (As) contamination of agricultural soils resulting from mining activity has caused major concern due to the potential health risk. Therefore the current study was carried out to investigate the relationship between fractionation of As in soil and rice uptake and to provide a basic information for adequate management of As contaminated agricultural soil. Twenty agricultural soils and rice affected by the abandoned mining sites were collected. Soil chemical properties and As concentrations (total and sequential extracted) in soils were determined and As concentrations in polished rice were analyzed. The average concentration of As in non-specifically adsorbed (F1), specifically adsorbed (F2), amorphous hydrous oxides of Fe and Al (F3), crystalline hydrous oxides of Fe and Al (F4) and residual phase (F5) were 0.08, 1.38, 10.34, 3.26 and 10.98 mg kg<SUP>-1</SUP>, respectively. Both soil pH and available phosphorus were positively correlated with the concentrations of As in F1 and F2. These results indicate that increasing the soil pH and available phosphorus can significantly increase the easily mobile fractions of As (F1 and F2). The average concentration of As in polished rice was 0.09 mg kg<SUP>-1</SUP>. The concentrations of As in F1 and F2 showed a positive correlation with the concentrations of As in polished rice. Therefore soil pH and available phosphorus affect the distribution of As fractionation in soils and thus affect As bioavailability.
Distribution of Arsenic Fraction in Soil Around Abandoned Mining Area and Uptake by Rice
Kim, Hyuck-Soo,Go, Woo-Ri,Kang, Dae-Won,Yoo, Ji-Hyock,Kim, Kye-Hoon,Kim, Won-Il 한국토양비료학회 2015 한국토양비료학회지 Vol.48 No.5
Arsenic (As) contamination of agricultural soils resulting from mining activity has caused major concern due to the potential health risk. Therefore the current study was carried out to investigate the relationship between fractionation of As in soil and rice uptake and to provide a basic information for adequate management of As contaminated agricultural soil. Twenty agricultural soils and rice affected by the abandoned mining sites were collected. Soil chemical properties and As concentrations (total and sequential extracted) in soils were determined and As concentrations in polished rice were analyzed. The average concentration of As in non-specifically adsorbed (F1), specifically adsorbed (F2), amorphous hydrous oxides of Fe and Al (F3), crystalline hydrous oxides of Fe and Al (F4) and residual phase (F5) were 0.08, 1.38, 10.34, 3.26 and $10.98mgkg^{-1}$, respectively. Both soil pH and available phosphorus were positively correlated with the concentrations of As in F1 and F2. These results indicate that increasing the soil pH and available phosphorus can significantly increase the easily mobile fractions of As (F1 and F2). The average concentration of As in polished rice was $0.09mgkg^{-1}$. The concentrations of As in F1 and F2 showed a positive correlation with the concentrations of As in polished rice. Therefore soil pH and available phosphorus affect the distribution of As fractionation in soils and thus affect As bioavailability.
국내 유통 약용작물 중 카드뮴, 수은, 납, 비소 함량 모니터링 및 위해성 평가
김혁수 ( Hyuck Soo Kim ),김권래 ( Kwon Rae Kim ),홍창오 ( Chang Oh Hong ),고우리 ( Woo Ri Go ),정선희 ( Seon Hee Jeong ),류지혁 ( Ji Hyock Yoo ),조남준 ( Nam Jun Cho ),홍진환 ( Jin Hwan Hong ),김원일 ( Won Il Kim ) 한국환경농학회 2015 한국환경농학회지 Vol.34 No.4
BACKGROUND: The current study was carried out to investigate Cd, Hg, Pb and As contaminations in 222commercial medicinal plants and to estimate the potential health risk through dietary intake of commercial medicinal plants in Korea.METHODS AND RESULTS: The Cd, Hg, Pb, and As in medicinal plants were analyzed by ICP/MS and mercury analyzer.The potential health risk was estimated using risk assessment tools. Total amount of Cd in medicinal plants with 29% samples exceeded the standard limit legislated in‘Pharmaceutical Affairs Act’ while all plant samples were lower than the standard limit value for As, Hg, and Pb.However, when applying the standard limit for rootvegetable (fresh weight) in the Food Sanitation Act, four samples exceeded the standard limit of Pb. For health risk assessment, the values of cancer risk probability were 0.3~5.9×10^{-7} which were less than the acceptable cancer risk of 10^{-6}~10^{-4} for regulatory purpose. Also, Hazard quotientvalues were lower than 1.0.CONCLUSION: Therefore, these results demonstrated that human exposure to Cd, Hg, Pb, and As through dietary intake of commercial medicinal plants might notcause adverse health effects although some medicinal plants were higher than the standard limit values for Cd and Pb.