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- 저자 : Jhun, Young-Seok (검색결과 613 건)
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Aggregation of an <i>n</i>–π* Molecule Induces Fluorescence Turn-on
Jhun, Byung Hak,Yi, Seung Yeon,Jeong, Donghyun,Cho, Jaeheung,Park, Soo Young,You, Youngmin American Chemical Society 2017 JOURNAL OF PHYSICAL CHEMISTRY C - Vol.121 No.21
<P>Although n-pi* molecules can serve as electroluminescent materials because of the harvesting of singlet and triplet excitons through El-Sayed-rule-allowed reverse intersystem crossing, the weak fluorescence emissions of such molecules have prevented applications into devices. We have discovered a 1 order of magnitude enhancement of the fluorescence of a prototypical n-pi* fluorophore, 7-phenylcoumarin (PC), upon aggregation. We performed a mechanistic study consisting of structural, photophysical, and quantum chemical investigations, and found that the aggregation positioned the fluorescent electronic state below the nonemissive tripletn-pi* transition state. Our studies, for the first time, demonstrate intramolecular geometry and intermolecular arrangements in the solid state to be significant factors in the photoluminescence quantum yields of n-pi* fluorophores.</P>
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A Study on the Tradition of Tea Ceremony and Cultural Industry in Japan
Jhun Jae Hyun 조선대학교 국제문화연구원 2013 국제문화연구 Vol.6 No.2
his year, as countries short in natural resources, both South Korean and Japanese government and industries have acknowledged that both needs to invest in improving their presence in cultural enterprises to utilize their national powers more efficiently and have been in talks to find a practical method to do so. It should be noted that Dado (다도, 茶道, tea ceremony) is a very important asset as a business and as acentral theme for multiple cultural enterprises. The purpose of this studyisto identify the current state of Japanese Dado (다도, 茶道, tea ceremony) and to utilize that information to develop contents which will boost South Koreas Dado (다도,茶道, tea ceremony). After being organized by Sen no Riky.(千利休 1522~1591) in the 14th century a tea ceremony Meister program was established around JapansE-ye-moto(家元) and became one of the most unique cultural system to represent Japans tea ceremony. Originally tea was brought over to Japan by monks who traveled abroad to Tang Dynasty (618~907) to study Buddhism. They would bring over the tea seeds and plant them in Seburi mountain located in Saga-hyun. Teas popularity hit near rock bottom until in 1911 where Eisai (1141-1215), who built the Shofujuki temple, brought back tea from the Song Dynasty. During the Muromachi period Dado (다도,茶道, tea ceremony) began to establish its basic form by embracing the flashy styles of Higashiyama culture. As a reaction to the overly extravagant ways, Murata Juk. (1432-1510) preferred a more simple and modest approach and established the Wabi tea style based on his philosophy that tea and meditation is one(다선일미, 茶禪一味). His style was passed down to Takeno J..(武野紹., 1502-1555) who in turn passed the torch to Sen no Riky. during the Azuchi-Momoyama period. Sen no Riky. perfected the art of tea ceremony and completed the Wabi tea culture started by Burata Shuko. Wabi tea is considered the original tea ceremony form for Japans tea culture and Sen no Riky. was the one who defined it. Sen no Riky. not only establish and refine the Wabi tea style but also the s.an tea (lit., "grass hermitage") which emphasized on freedom and practicality. Sen no Riky.s pupil Yamanoue Shoji (1544-1590) added his philosophy ofIchigo-Ichieh (一期一會lit., Once in a lifetime) to that of Shikishichisoku of Sen no Riky. and continued to improve upon it. Tea began to reach the general public only after modern era. There are three groups who make up the Sansenke, which is in the very heart of Japanese tea culture, and they are Omote Senke (1613~1672), Ura Senke, Mushano Kouji Senke. Some also consider Yabunouchi Ryu and Sadohayami Ryu and call them the big five. Japan has not only embraced Tea ceremony as part of their cultural heritage but also has turned it into a great medium and utilized it in various business and content creations to raise its marketability. First of all, various venues such as Tanabe museum, Irimashi museum, Tea information center and culture centers hold tea ceremonies and classes where everyone can join in for anominal fee. Second, places such as Numas Koyotei Memorial Park, Uahhonjin park, Porenakakawane Tea center, Shijuokas Tea center, Shimistei Park serves tea to the general public and also hold entertainment events with Tea infused into their programs. Third, various mediums such as Ang Donuts, Nihonjinno shiranai Nihongo (Japanese even Japanese don't know), Hanayori Dango, Aoki Sachikos Chabashirakuri comic in weekly publication Times, and Japanese webtoon the Tears of Tea-Larmes de The by Minamo Kaeroo published in EDEN provides multiple angles for tea to reach the general public and last, sales of tea drinks, instant teas, and tea related character products for adding values to teas. As seen above the reasonwhyDado (다도, 茶道, tea ceremony) has become so accessible to the public was due to the abundant amount of information provided via media and public services and the sales of various tea and tea related products. Enjoying tea is no longer a luxury but apart of every days life as ahobby or for fashion. South Korea should learn and absorb the strong points of Japanese practices and begin spreading the Dado (다도, 茶道, tea ceremony) spirit by naturally augmenting Dado (다도, 茶道, tea ceremony) into everyday activities.
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Jhun, Byung Woo,Moon, Seong Mi,Kim, Su-Young,Park, Hye Yun,Jeon, Kyeongman,Kwon, O Jung,Huh, Hee Jae,Ki, Chang-Seok,Lee, Nam Yong,Chung, Myung Jin,Lee, Kyung Soo,Shin, Sung Jae,Daley, Charles L.,Koh, American Society for Microbiology 2018 Antimicrobial agents and chemotherapy Vol.62 No.2
<P>Intermittent, three-times-weekly oral antibiotic therapy is recommended for the initial treatment of noncavitary nodular bronchiectatic (NB) Mycobacterium avium complex (MAC) lung disease. However, intermittent therapy is not recommended for patients who have been previously treated. We evaluated 53 patients with recurrent noncavitary NB MAC lung disease who underwent antibiotic treatment for >= 12 months with daily therapy (n = 26) or intermittent therapy (n = 27) between January 2008 and December 2015. Baseline characteristics were comparable between daily therapy and intermittent therapy groups. Sputum culture conversion rates did not differ between daily therapy (21/26, 81%) and intermittent therapy (22/27, 82%) groups. Compared to the etiologic organism at the time of previous treatment, recurrent MAC lung disease was caused by the same MAC species in 38 patients (72%) and by a different MAC species in 15 patients (28%). Genotype analysis in patients with sequenced paired isolates revealed that 86% (12/14) of cases with same species recurrence were due to reinfection with a new MAC genotype. In conclusion, most recurrent noncavitary NB MAC lung disease cases were caused by reinfection rather than relapse. Intermittent antibiotic therapy is a reasonable treatment strategy for recurrent noncavitary NB MAC lung disease.</P>
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Jhun, Hyung-Joon,Kim, Ho,Cho, Sung-Il The Korean Academy of Medical Sciences 2011 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.26 No.5
<P>We examined time trend and age-period-cohort effects on acute myocardial infarction (AMI) mortality in Korean adults from 1988 to 2007. Annual AMI mortality data and population statistics from 1988 to 2007 were obtained from the STATISTICS KOREA website. Age adjusted mortality for four 5-yr calendar periods (1988-1992 to 2003-2007) was calculated by direct standardization using the Year 2000 WHO world standard population. A log-linear Poisson regression model was used to estimate age, period, and cohort effects on AMI mortality. In both genders, age-adjusted AMI mortality increased from period one (1988-1992) to period three (1998-2002) but decreased in period four (2003-2007). An exponential age effect was noted in both genders. The rate ratio of the cohort effect increased up to the 1943 birth cohort and decreased gradually thereafter, and the rate ratio of the period effect increased up to period three (1998-2002) and decreased thereafter. Our results suggest that AMI mortality in Korean adults has decreased since the period 1998-2002 and age, period, and cohort effects have influenced on AMI mortality.</P>
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Evidence for the Ras-Independent Signaling Pathway Regulating Insulin-Induced DNA Synthesis
Jhun, Byung H. The Korea Science and Technology Center 1999 BMB Reports Vol.32 No.2
The existence of the Ras-independent signal transduction pathway of insulin leading to DNA synthesis was investigated in Rat-1 fibroblasts overexpressing human insulin receptor (HIRc-B) using the single-cell microinjection technique. Microinjection of a dominant-negative mutant Ras protein into quiescent HIRc-B cells inhibited the DNA synthesis stimulated by insulin. Microinjection of oncogenic H-Ras protein (H-Ras) (0.1㎎/ml) induced DNA synthesis by 35%, whereas that of control-injected IgG was induced by 20%. When the maginal amount of oncogenic H-Ras protein was coinjected with a dominant-negative mutant of the H-Ras protein(H-Ras), DNA synthesis was 35% and 74% in the absence and presence of insulin, respectively. This full recovery of DNA synthesis by insulin suggests the existence of the Ras-independent pathway. The same recovery was observed in the cells coinjected with either H-Ras H-Ras plus SH2 domain of the p85 subunit of PI3-kinase(p85) or H-Ras plus H-Ras plus interfering anti-Shc antibody. When coinjected with a dominant-negative Rac1, the DNA synthesis induced by the Ras-independent pathway was blocked. These results indicate that the Ras-independent pathway of insulin leading to DNA synthesis exists, bypassing the p85 of PI3-kinse and Shc protein, and requires Rac1 protein.
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The 100 most-cited articles on non-tuberculous mycobacterial infection from 1995 to 2015
Jhun, B. W.,Kim, S.-Y.,Kong, J. H.,Park, J. R.,Park, S. Y.,Shim, M. A.,Jeon, K.,Park, H. Y.,Shin, S. J.,Koh, W.-J. IUATLD 2017 The international journal of tuberculosis and lung Vol.21 No.1
<P>CONCLUSION: A large proportion of influential articles on NTM infection are basic scientific studies, and the most influential articles are not always published in high-impact journals.</P>
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Germ cell-specific apoptosis by extracellular clusterin in cryptorchid dog testes
Jhun, Hyunjhung,Park, Hyun-Jung,Lee, Ran,Song, Hyuk,Hur, Tai-Young,Lee, Seunghoon,Park, Jin-Ki,Lee, Won-Young Elsevier 2018 Animal reproduction science Vol.193 No.-
<P><B>Abstract</B></P> <P>Mammalian testes are maintained at a relatively lesser temperature than the abdominal region so that normal spermatogenesis can occur. Germ cell apoptosis has resulted in heat-damaged testes that occurs as a result of cryptorchidism, but the mechanism is not yet fully understood. To elucidate the cause of germ-cell death by cryptorchidism, cryptorchidism was surgically induced in dog testes and histological and molecular analyses were performed. Histological data indicated that the seminiferous tubules of cryptorchid testes and epididymis contained fewer germ cells. Total RNA sequencing was performed to screen for overexpressed genes in cryptorchid dog testes. Clusterin RNA was in greater abundance (approximately 12.8-fold) in cryptorchid testes than in normal testes. In addition, cleaved caspase-3 and -8 were detected in greater abundance in cryptorchid dog testes. Real time RT-PCR and western blotting analysis indicated there was a greater abundance of clusterin in cryptorchid dog testes. Furthermore, clusterin was detected in extracellular regions of cryptorchid dog testes during the 4 weeks after surgery. Thus, germ-cell specific apoptosis and expression of clusterin genes occur with a resulting presence of this protein in extracellular regions of cryptorchid dog testes. This result will facilitate further study of spermatogenesis and the specific mechanisms by which cryptorchidism results in male infertility.</P>
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