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      • Exhaled Breath Analysis System based on Electronic Nose Techniques Applicable to Lung Diseases

        변형기,유준부,Jeung-SooHuh,임정옥 한양대학교 의과대학 2014 Hanyang Medical Reviews Vol.34 No.3

        Smell used to be a common diagnostic tool in medicine, and physicians were trained to use their sense of smell during their medical training. Latterly, odor disgnostics have been relegated to secondary status as a diagnostic method. Array-based gas sensors (“Electronic Nose”) now offer the potential of a robust analytical approach to exhaled breath analysis for medical use. Many diseases are accompanied by characteristic odor, and their recognition can provide diagonostic clues, guide the laboratory evaluation, and affect the choice of immediate therapy. We are developing an intelligent sensor system for non-invasive health care monitoring combined laboratory based sensor module, pattern recognition subsystem and non-invasive sampling of volatile emitted from a patient into a highly intelligent sensor system that allows the rapid processing of these samples. It is capable to assist early and rapid disgnosis of changes in state of patient, and aid decision making by medical personnel in the treatment of such patients. In this paper, we introduce exhaled breath analysis for potential primary lung disease screening using electronic nose system incorporating an automated solid-phase microextraction (SPME) desorption to enable the system to be used. Aiming to increase the sensitivity, SPME preconcentration is used for sampling of headspace air and the response of sensor module to variable concentration of volatile emitted from SPME fiber is evaluated. The initial result shows the distinguished difference between the lung cancer patients and healthy normal individuals according to the analysis of the respective expiratory gases.

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        Room Temperature Hard Radiation Detectors Based on Solid State Compound Semiconductors: An Overview

        Ali Mirzaei,Jeung-SooHuh,김상섭,김현우 대한금속·재료학회 2018 ELECTRONIC MATERIALS LETTERS Vol.14 No.3

        Si and Ge single crystals are the most common semiconductor radiation detectors. However, they need to work at cryogenictemperatures to decrease their noise levels. In contrast, compound semiconductors can be operated at room temperaturedue to their ability to grow compound materials with tunable densities, band gaps and atomic numbers. Highly efficientroom temperature hard radiation detectors can be utilized in biomedical diagnostics, nuclear safety and homeland securityapplications. In this review, we discuss room temperature compound semiconductors. Since the field of radiation detectionis broad and a discussion of all compound materials for radiation sensing is impossible, we discuss the most importantmaterials for the detection of hard radiation with a focus on binary heavy metal semiconductors and ternary and quaternarychalcogenide compounds.

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        Interfacial Layer Effect on the Adhesion of the Ultra-Hard Thick TAC Film Deposition

        Sang-Won Lim,Jeung-SooHuh 대한금속·재료학회 2023 JOURNAL- KOREAN INSTITUTE OF METALS AND MATERIALS Vol.61 No.3

        Carbon-based thin film tool coatings, such as diamond-like carbon (DLC), have excellent lowfrictionand anti-sticking properties. These thin films are widely used for the cutting and machining ofincreasingly widely-used lightweight non-metallic and non-ferrous metal materials, as a part ofcountermeasures against global warming. However, non-metallic and non-ferrous metal materials aresignificantly inferior in strength and heat resistance compared to iron-based metals. Therefore, they areprimarily employed in high-content fiber reinforced composite materials, which significantly improves theirmechanical and thermal properties. Tetrahedral amorphous carbon (TAC) coating has a hardness levelsimilar to diamond coating. However, when TAC is deposited as a thick film, delamination of the coatinglayer may occur because of the high internal compressive stress between the carbide-based substrate andcoating layer, thereby restricting its scalability to other applications. Other factors to be controlled for thickfilm TAC deposition include minimizing droplets generated during the coating process, and improvinginterfacial properties like hardness and fatigue resistance. Here, C in the form of CH4, which has highsolubility over Cr and forms various compounds, was added during the interfacial deposition process,between the carbide and TAC, to improve interfacial strength and adhesion by precipitation of carbide atthe interface. This eventually led to thick TAC film with the thickness and adhesion of commercially viablethick film.

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