http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : Jeum-Jae Cho (검색결과 2 건)
- 무료
- 기관 내 무료
- 유료
-
흰쥐에서 Ursodeoxycholic Acid 및 Silymarin을 함유한 의약조성물(DWP305)의 연용투여에 의한 간내 담즙산 조성변화
조재열(Jae Youl Cho),연제덕(Je Deuk Yeon),남권호(Kweon Ho Nam),김점용(Jeum Yong Kim),유은숙(Eun Sook Yoo),유영효(Young Hyo Yu),박명환(Myung Hwan Park) 대한약학회 1996 약학회지 Vol.40 No.3
DWP305, a preparation containing combination of ursodeoxycholic acid(UDCA), silymarin and vitamins (B1 and B2), is a drug currently being developed for hepatic disorders. In order to evaluate the changes in hepatic function by multiple oral administration(2 and 4 weeks) of DWP305 in rats, several biochemical parameters in blood, bile acid composition, and the accumulation of UDCA and lithocholic acid(LCA),a toxic metabolite formed by enterobacteria, were examined using HPLC. In blood biochemical findings, DWP305 did not affect the normal level and there was no difference in total bile acid composition for UDCA, cholic acid(CA), deoxycholic acid(DCA), chenodeoxycholic acid(CDCA) and LCA compared to the UDCA administered group, although total ratio of UDCA and CA was different from normal group. In case of ratio of taurine and glycine conjugated forms, DWP305(186mg/kg as a UDCA) administered group was also similar to normal group and UDCA administered group, while high dosing of DWP305 was not different in the ratio of UDCA administered group(930mg/kg) but normal group. And the ratio of LCA was in order of UDCA(930mg/kg), DWP305(930mg/kg as a UDCA), UDCA(186mg/kg) and DWP305(186mg/kg as a UDCA) administered group, which was less than 4%. The free form of UDCA as well as most of bile acids was not detected at all in rat liver, indicating that there''s no accumulation. These results suggest that multiple dosing of DWP305 in rats may not affect hepatic biotransformation and metabolism of bile acids.
-
유기산의 해리평행에 미치는 치환기효과와 그의 온도 및 압력의 영향. (5) 수용액에서 루신의 해리상수
황정의,이우붕,조점제,Jung-Ui Hwang,Wo-Bung Lee,Jeum-Jae Cho 대한화학회 1987 대한화학회지 Vol.31 No.5
루신의 해리상수를 전도도법을 이용하여 온도(15 to 40$^{\circ}$C)와 압력(1~2,500bar)을 변화시키면서 측정했다. 루신의 두가지 해리상수는 온도가 높아지면 모두 증가하였다. 그러나 압력이 높아지면 첫째 해리상수는 증가하였으나 둘째 해리상수는 낮은 온도에서는 감소하고 높은 온도에서는 증가했다. 이들 해리상수를 이용하여 해리반응의 열역학적 성질들을 계산하고 이들 성질로부터 해리반응의 특성을 알아보았다. The two dissociation constants of leucine were measured in the temperature range from 15 to 40$^{\circ}$C and pressure up to 2,500 bar by conductometric method. Both constants were increased as the temperature increased but pressure effect was not same as temperature effect. The first constants were increased as pressure increase but the second constants were decreased as pressure increase in the law temperature range but increased in some higher temperature range. These phenomena were discussed from the thermodynamic properties of the dissociation reactions.
ScienceON
스콜라연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
