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- 저자 : Jean Ramon (검색결과 4 건)
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Pedro Ramon,Jean Sparks,Felix Omoruyi 한국식품영양과학회 2021 Journal of medicinal food Vol.24 No.7
Diabetes Mellitus is associated with systemic inflammation and oxidative stress, which may play a central role in the development of diabetic complications. In this study, combined preparations of Kalanchoe pinnata and metformin were investigated to determine the effects on inflammatory activity in human skeletal muscle myoblasts (HSMMs) and human diabetic skeletal muscle myoblasts (DHSMMs). Results showed that combinatorial preparations sustained cell viability for 3 days in both HSMM and DHSMM cells. However, a significant decrease in cellular viability occurred for both cell lines on day 5. Results also indicate that combinatorial preparations of K. pinnata may modulate immune responses by significantly upregulating proinflammatory markers, interleukin (IL) 2, and tumor necrosis factor-alpha, and upregulating the anti-inflammatory marker, IL-10, in HSMM and DHSMM cells. The combined preparations significantly downregulated the anti-inflammatory glycoprotein IL-6 in both diabetic and nondiabetic human skeletal muscle cells. The findings suggest that combined preparations of K. pinnata and metformin might be a potential immune-modulating agent that may promote inflammation and adversely affect the outcome of diabetic patients.
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Synthesis of Pegylated Immunonanoparticles
Oliver, Jean-Christophe,Huertas, Ramon,Lee, Hwa Jeong,Calon, Frederic,Pardridge, William M. 梨花女子大學校 藥學硏究所 2002 藥學硏究論文集 Vol.- No.11
Purpose. This work describes the syrthesis of pesylated immu-nonanoparticies by conjugation of an anti-transferrin receptor mono-clonal antibody (MAb) to maleimide-grafted pegylated nanoparticlesprepared from poly(lactic acid) (PLA) and a hi-functional polyeth-yleneglycol (PEG).Methods. Maleimide-PEG_3500-PLA_4000 and methoxy PEG_2600-PLA_4000 copolymers were synthesized by ring opening polymeriza-tion of L-lactide using stannous octoate as catalyst. Pegylated nano-particles were prepared from these copolymers by a multiple emul-sion/solvent evaporation method and thiolated OX26 MAb wasconjugated through the maleimide function located at the distal endof the PEG spacer. The pegylated immunonanoparticles were char-actenzed by quasi-elastic light scattering, gel permeation chromatog-raphy, turbidimetry assays, and transmission electron microscopy.Results. NMR spectroscopy confirmed the synthesis of both copoly-mers and the preservation of the maleimide function. The pegylatedimmunonanoparticles had an auerage diameter of 121 ± 5 nm andappeared spherical by transmission electron microscopy. The numberof OX26 MAb molecules conjugated per individual pegylated nano-particle was 67 ± 4. The MAb conjugated to the surface of the pe-gylated immunonanoparticle was visualized directly by electron mi-croscopy using a conjugate of 10 nm gold and an anti-mouse immu-noglobulin secondary antibody.Conclusion. Pegylated immunonanopartirles can be synthesized withbifunctional PEG derivatives that bridge the nanoparticle and thetargeting MAb. This novel formulation may enable the targeted de-livery of small molecules, protein drugs, and gene medicines.
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Felipe Lovaglio Belozo,Carlos K. Katashima,André V. Cordeiro,Luciene Lenhare,Jean F. Alves,Vagner Ramon Rodrigues Silva 한국운동재활학회 2018 JER Vol.14 No.1
The main objective of this study was to examine the effect of continu-ous aerobic training (CAT) in hypertensive, obese people. Seven pa-tients of average age (45.3±3.9 years), height (1.63±0.1 m), body weight (89.09±22.0 kg), and body mass index (33.44±8.6 kg/m2) were subjected to the training. CAT was performed in thrice-weekly nonconsecutive sessions (90 min per week) with intervals of 48 hr between each ses-sion. The training sessions entailed 30 min of walking at an intensity of 70%–80% of the maximum heart rate (MHR) on a treadmill over a period of eight weeks, giving a total of 24 sessions. Through correlation analy-ses, we found significant improvement in the systolic pressure (R=0.5675, P=0.0253) and diastolic pressure (R=0.7083, P=0.0088) when the last session was compared to the first session of training. We found no differences in the diastolic pressure and systolic pressure be-fore, during and after 15 min of the protocol exercise. The program showed a large effect size (ES) for systolic pressure (ES=0.85) and a small ES for diastolic pressure (ES=0.33). We found no differences in the blood pressure (BP) and heart rate (HR) during and after the training of obese hypertensive humans, but we found a positively significant correlation between HR and BP in the last session and a large ES, sug-gesting that this protocol exercise might have significance effect in the long term.
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Design and 3D-printing of titanium bone implants: brief review of approach and clinical cases
Vladimir V. Popov Jr.,Gary Muller-Kamskii,Aleksey Kovalevsky,Georgy Dzhenzhera,Evgeny Strokin,Anastasia Kolomiets,Jean Ramon 대한의용생체공학회 2018 Biomedical Engineering Letters (BMEL) Vol.8 No.4
Additive manufacturing (AM) is an alternative metal fabrication technology. The outstanding advantage of AM (3Dprinting,direct manufacturing), is the ability to form shapes that cannot be formed with any other traditional technology. 3D-printing began as a new method of prototyping in plastics. Nowadays, AM in metals allows to realize not only netshapegeometry, but also high fatigue strength and corrosion resistant parts. This success of AM in metals enables newapplications of the technology in important fields, such as production of medical implants. The 3D-printing of medicalimplants is an extremely rapidly developing application. The success of this development lies in the fact that patientspecificimplants can promote patient recovery, as often it is the only alternative to amputation. The production of AMimplants provides a relatively fast and effective solution for complex surgical cases. However, there are still numerouschallenging open issues in medical 3D-printing. The goal of the current research review is to explain the whole technologicaland design chain of bio-medical bone implant production from the computed tomography that is performed by thesurgeon, to conversion to a computer aided drawing file, to production of implants, including the necessary post-processingprocedures and certification. The current work presents examples that were produced by joint work of Polygon MedicalEngineering, Russia and by TechMed, the AM Center of Israel Institute of Metals. Polygon provided 3D-planning and 3Dmodellingspecifically for the implants production. TechMed were in charge of the optimization of models and theymanufactured the implants by Electron-Beam Melting (EBM ), using an Arcam EBM A2X machine.
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