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선천성 거대결장증 진단에 필요한 조직화학염색 : Rapid Acetylcholinesterase Staining
설지영,김제룡,김진만,장일성 충남대학교 의학연구소 2001 충남의대잡지 Vol.28 No.2
Hirschsprung's disease is a congenital absence of ganglion cells in the Meissner's and Auerbach's plexuses of the colon. The definitive diagnosis of the disease can only be based on histologic examination of bowel wall biopsies demonstrating aganglionosis. To distinguish Hirschsprung's disease from other causes of contipation and megacolon, it is helpful to use histologic examination with routine hematoxylin and eosin (H&E) staining and acetylcholinesterase (AChE) special histochemical staining techniques. With H&E staining, the difficulties may arise in the hypoganglionic area of the transition zone, or in hypoganglionosis or neuronal intestinal dyspiasia. The AChE technique provides reliable identification of ganglion cells by staining nerve filaments in close proximity to the ganglion cells. However, the conventional AChE technique takes about 2 hours for the examination of specimens, so it is not suitable for intraoperative examination. Using a rapid AChE histochemical staining technique, it is possible to produce staining of cholinergic fibers in 20 minutes. It should enable the surgeon to use it selectively during operation and to support or refute the H&E findings.
배진선,송인상,김제룡 충남대학교 의과대학 지역사회의학연구소 1999 충남의대잡지 Vol.26 No.1
The intrahepatic calculi are prevalent in east Asia and are regarded as malignant disease because diagnosis and treatment are difficult and complication and mortality are high. This study is a retrospective clinical review of 47 cases of patient with intrahepatic calculi in the Department of Surgery, Chungnam National University Hospital from January 1994 through December 1998. The incidence of intrahepatic calculi was 8.5% of total biliary calculi. The ratio of male to female was 1:19. The peak incidence was noted at the 6th decade (29.8%) and mean age was 50. 9 years. About the site of stones, left intrahepatic duct (51%)was more prevalent than right intrahepatic duct (19%). 32 cases(70%) of the intrahepatic calculi were associated with GB stone (8%), CBD stone(45%) or both(17%). As to surgical method, choledochotomy with T-tube drainage was performed in 27 cases(57%), choledochoduodenostomy was in 3 cases(7%) and hepatic resection in 17 cases(36%). Among them choledochotomy with T-tube drainage was the most frequently performed procedure. The remnant stones are most commonly founded after choledochotomy and T-tube drainage (70%) followed by 33% after choledochoduodenostomy and 29% after hepatic resection. But, major postoperative complications such as bile leakage and intraabdominal abscess are more frequent in cases of hepatic resection. So we suggest that agressive treatment modality such as hepatic resection is more reasonable than drainage procedure in the management of intrahepatic duct stone by the experienced expert.
배진선,길기선,설지영,김제룡 충남대학교 의과대학 지역사회의학연구소 1999 충남의대잡지 Vol.26 No.1
A retrospective clinical analysis was performed on 152 patients with cholelithiasis who were admitted and treated surgically at the Department of Surgery of Chungnam National University Hospital from January 1995 through December 1996. The results were as follows. 1. The peak incidence of cholelithiasis was 6th decade (27.6%), followed by 7th decade, and the ratio of male to female was 1:1.3. 2. The duration of symptoms was within 1 month in 44.7% of patients. 3. The most common symptom and sign were RUQ abdominal pain (89.5%) and RUQ abdominal tenderness (58.6%). 4. The positive laboratory findings were eleveated ALT (42.8%), elevated AST (38.2%) and leukocytosis (38.8%). 5. The major associated conditions in cholelithiasis were cholecystitis (59.7%), cholangitis (15. 1%) and pancreatitis (9.2%). 6. The location of stones was most prevalent in the gallbladder (86.1%), followed by in the common bile duct (26.9%), and in the intrahepatic duct (12.5%). 7. The most common operative procedure was cholecystectomy (63.2%), followed by cholecystectomy and T-tube drainage (15.8%). 8. Bile was cultured in 44 cases, and the most frequent microorganism was E. coli (40.9%). 9. The postoperative complication rate was 34 of 152 (22.4%), among which residual stone and wound infection were most frequent. 10. The operative mortality was 0.7% and the cause of death was sepsis.
갑상선 수질암과 갑상선 유두암의 충돌종양: 5예 증례보고
정호철,김제룡,안병현,이진선,장일성,김진만1,Ho Chul Jeong,Je Ryong Kim,Byong Hyon Ahn,Jin Sun Lee,Eil Sung Chang,Jin Man Kim1 대한갑상선-내분비외과학회 2014 The Koreran journal of Endocrine Surgery Vol.14 No.1
Medullary thyroid carcinoma and papillary thyroid carcinoma are different subtypes of thyroid carcinoma. The concomitant occurrence of medullary thyroid carcinoma and papil-lary thyroid carcinoma as a collision tumor is rare. We describe five cases of medullary and papillary thyroid carcinoma as a collision tumor. Four women and one man underwent thyroidectomy for treatment of thyroid cancer. Collision tumor was then detected by histopathologic finding. Genetic testing, point mutation of the BRAF gene or mutation of the RET gene was performed in three cases. However, only one case had point mutation of the BRAF gene. Exact diagnosis of this uncommon event is important because the strategies for treatment of papillary thyroid carcinoma and medullary thyroid carcinoma are different.
Neurotoxicity of microglial cathepsin D revealed by secretome analysis
Kim, Sangseop,Ock, Jiyeon,Kim, Ae Kyung,Lee, Ho Won,Cho, Je-Yoel,Kim, Deok Ryong,Park, Jae-Yong,Suk, Kyoungho Raven Press [etc.] 2007 Journal of neurochemistry Vol.103 No.6
<P>Abstract</P><P>Microglia-driven inflammatory responses have both neuroprotective and neurotoxic effects in the CNS. The excessive and chronic activation of microglia, however, may shift the balance towards neurotoxic effects. In this regard, proteins secreted from activated microglia likely play a key role in the neurotoxic effects. To characterize secreted proteins of activated microglia, conditioned media obtained from BV-2 mouse microglia cells were analyzed by two-dimensional gel electrophoresis or liquid chromatography coupled with tandem mass spectrometry. Among many proteins identified in the secretome of activated microglia, an aspartic endoprotease cathepsin D has been found to mediate microglial neurotoxicity based on the following results: (i) the expression of cathepsin D protein was markedly increased in lipopolysaccharide/interferon-&ggr;-stimulated microglia compared with resting microglia as determined by western blot analysis of conditioned media; (ii) knockdown of cathepsin D expression in microglia using short hairpin RNA diminished the neurotoxicity in the coculture of microglia and neuroblastoma cells and (iii) recombinant procathepsin D protein exerted cytotoxic effects toward cultured neurons. In conclusion, cathepsin D appears to play a central role in the microglial neurotoxicity, and could be a potential biomarker or drug target for the diagnosis and treatment of neurodegenerative diseases that are associated with excessive microglial activation and subsequent neurotoxic inflammation.</P>
Kim, Soon Sun,Cho, Hyo Jung,Nam, Ji Sun,Kim, Hyun Ji,Kang, Dae Ryong,Won, Je Hwan,Kim, Jinoo,Kim, Jai Keun,Lee, Jei Hee,Kim, Bo Hyun,Lee, Mi Young,Cho, Sung Won,Cheong, Jae Youn KOREAN ACADEMY OF MEDICAL SCIENCE 2018 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.33 No.1
<P><B>Background</B></P><P>We investigated an association between the levels of plasma microRNA (miRNA)-21, -26a, and -29a-3p and treatment outcomes following transarterial chemoembolization (TACE) in patients with hepatocellular carcinoma (HCC).</P><P><B>Methods</B></P><P>A total of 198 patients with TACE-treated HCC were followed up for TACE refractoriness and liver transplantation (LT)-free survival. Pretreatment plasma miRNA-21, -26a, and -29a-3p levels were measured using quantitative real-time polymerase chain reaction.</P><P><B>Results</B></P><P>During the mean follow-up of 22.3 (range, 0.7–79) months, 118 (59.6%) patients exhibited TACE refractoriness. Multivariate analyses showed that expression of a specific combination of miRNAs (miRNA-21 ≥ 2.5, miRNA-26a ≥ 1.5, and miRNA-29a-3p < 0.4) was associated with early TACE refractoriness (within 1 year; hazard ratio [HR], 2.32; 95% confidence interval [CI], 1.08–4.99; <I>P</I> = 0.031) together with tumor size (HR, 4.62; 95% CI, 1.50–14.21; <I>P</I> = 0.008), and macrovascular invasion (HR, 3.80; 95% CI, 1.19–12.20; <I>P</I> = 0.025). However, miRNA-21, -26a, and -29a-3p levels were not significantly associated with overall TACE refractoriness or LT-free survival. Additionally, large tumor size and macrovascular invasion were common predictive factor of overall TACE refractoriness and survival.</P><P><B>Conclusion</B></P><P>Combination of plasma miRNA-21, -26a, and -29a-3p expression could predict early TACE refractoriness in patients with TACE-treated HCC.</P>
Kim, Sang-Tae,Lee, Seung-Yeon,Kim, Seung-Chul,Byun, Hye-Won,Lee, Sang-Tae,Kim, Mu-Yeal,Hong, Seok-Pyo,Chung, Young-Jae,Park, Ki-Ryong,Lee, Chung-Hee,Lee, Joong-Ku,Heo, Kyeong-In,Lee, Ji-Ye,Lee, Eun-Je National Science Museum of Korea 2011 Journal of Korean nature Vol.4 No.3
We developed the educational purpose mobile application, named "Wild Flowers of Bukhansan National Park (version 1.0)", aiming for easy identification of wild flowers for students and visitors in the park. When visitors find a flower or part of plant in the park, visitors can search for its name utilizing the pictures and characters provided in their own smartphone mobile devices or tablet PCs. The application provides pictures of wild flowers in the park and character-based searching system based on 12 diagnostic features (e.g., growth form, leaf arrangement, flower symmetry, petal color, petal number, sepal number, etc). We adopted the complete floristic survey of Chung and Lee (1962) and added species that we confirmed their distribution in the park during the development of this application. In summary, number of vascular plants in this park was estimated to be 428 taxa including 100 families, 280 genera, 327 species, 1 subspecies, 50 varieties, and 5 formas. We provided a total of 588 pictures representing 358 taxa and each taxon includes multiple pictures in many cases. Included identification quizzes can be an efficient educational tool as well as fun activity for students and visitors who are learning plant species in Korea. Our next step will include GPS function in the application for indicating visitor's location and for providing previously reported sites of the species that we interested in the map of the park. The future application which includes GPS function will be a valuable tool for the monitoring of rare plants, plant researches related to the climate changes, etc. We currently provide Korean iPhone version only, and English version and both of android versions will be serviced soon.