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( Jason M. Park ),( Christian M. Ponder ),( B. Trevor Sewell ),( Michael J. Benedik ) 한국미생물 · 생명공학회 2016 Journal of microbiology and biotechnology Vol.26 No.12
Nitrilases pose attractive alternatives to the chemical hydrolysis of nitrile compounds. The activity of bacterial nitrilases towards substrate is intimately tied to the formation of large spiral-shaped oligomers. In the nitrilase CynD (cyanide dihydratase) from Bacillus pumilus, mutations in a predicted oligomeric surface region altered its oligomerization and reduced its activity. One mutant, CynD Y70C, retained uniform oligomer formation however it was inactive, unlike all other inactive mutants throughout that region all of which significantly perturbed oligomer formation. It was hypothesized that Y70 is playing an additional role necessary for CynD activity beyond influencing oligomerization. Here, we performed saturation mutagenesis at residue 70 and demonstrated that only tyrosine or phenylalanine is permissible for CynD activity. Furthermore, we show that other residues at this position are not only inactive, but have altered or disrupted oligomer conformations. These results suggest that Y70`s essential role in activity is independent of its role in the formation of the spiral oligomer.
Low-energy spin dynamics of orthoferrites AFeO<sub>3</sub> (A = Y, La, Bi)
Park, Kisoo,Sim, Hasung,Leiner, Jonathan C,Yoshida, Yoshiyuki,Jeong, Jaehong,Yano, Shin-ichiro,Gardner, Jason,Bourges, Philippe,Klicpera, Milan,Sechovský,, Vladimí,r,Boehm, Martin,Park, Je IOP 2018 Journal of physics, an Institute of Physics journa Vol.30 No.23
<P>YFeO<SUB>3</SUB> and LaFeO<SUB>3</SUB> are members of the rare-earth orthoferrites family with <I>Pbnm</I> space group. Using inelastic neutron scattering, the low-energy spin excitations have been measured around the magnetic Brillouin zone center. Splitting of magnon branches and finite magnon gaps (∼2 meV) are observed for both compounds, where the Dzyaloshinsky–Moriya interactions account for most of this gap with some additional contribution from single-ion anisotropy. We also make comparisons with multiferroic BiFeO<SUB>3</SUB> (<I>R3c</I> space group), in which similar behavior was observed. By taking into account all relevant local Dzyaloshinsky–Moriya interactions, our analysis allows for the precise determination of all experimentally observed parameters in the spin-Hamiltonian. We find that different properties of the <I>Pbnm</I> and <I>R3c</I> space group lead to the stabilization of a spin cycloid structure in the latter case but not in the former, which explains the difference in the levels of complexity of magnon band structures for the respective compounds.</P>
Kim, Jason Y.,Cheong, Hyun Sub,Park, Byung-Lae,Baik, Sei Hyun,Park, Sunmin,Kim, Seogho,Shin, Hyoung Doo,Kim, Sung-Hoon Informa UK Ltd. 2013 Gynecological endocrinology Vol.29 No.10
<P>We hypothesized that <I>ubiquitin-conjugating enzyme E2 E2</I> (<I>UBE2E2</I>) may be associated with gestational diabetes mellitus (GDM) and conducted association analyses. A total of 2071 subjects were recruited for the study, with 1104 cases and 967 controls. Two <I>UBE2E2</I> single-nucleotide polymorphisms <I>rs6780569</I> and <I>rs7612463</I>, and their haplotypes were analyzed for the study. As a result, <I>rs7612463</I> showed a significant association with GDM in the recessive model. In addition, the regression analyses for the phenotypes showed that <I>rs6780569. rs7612463</I> and <I>ht2</I> showed significant associations with fasting plasma glucose (FPG) in recessive models, while <I>ht1</I> showed an association in the dominant model. Our results show that the genetic variants of <I>UBE2E2</I> are associated with GDM and FPG, which could be an important preliminary result for future studies.</P>
Kim, Jason Yongha,Kim, Jeong-Hyun,Park, Byung-Lae,Pasaje, Charisse Flerida A.,Bae, Joon Seol,Uh, Soo-Taek,Kim, Yong-Hoon,Kim, Mi-Kyeong,Choi, Inseon S.,Cho, Sang Heon,Choi, Byoung Whui,Park, Jong Sook Informa Healthcare 2012 The Journal of asthma Vol.49 No.3
<P><I>Background.</I> The <I>discoidin domain receptor tyrosine kinase 1</I> (<I>DDR1</I>) is positioned within the major histocompatibility complex (MHC) region which plays an important role in the immune system. In addition, DDR1 has been elucidated to be downregulated during the epithelial-mesenchymal transition of bronchial epithelium. <I>Objective.</I> To investigate the potential genetic associations between <I>DDR1</I> and aspirin-exacerbated respiratory disease (AERD), this study conducted association studies of <I>DDR1</I> single nucleotide polymorphisms (SNPs) with AERD and the obstructive symptom of forced expiratory volume in 1 s (FEV<SUB>1</SUB>) decline after aspirin provocation. <I>Methods.</I> Nine common SNPs were genotyped in 93 AERD patients and 96 aspirin-tolerant asthma (ATA) controls. The genotype distributions of all loci were in Hardy-Weinberg equilibrium (HWE; <I>p</I> > .05). <I>Results.</I> In the results of logistic analyses using age, sex, smoking status, and atopy as covariates, <I>DDR1 rs1264320</I> in the intronic region showed a potent association signal with FEV<SUB>1</SUB> decline by aspirin provocation in asthmatics of this study even after corrections for multiple testing (<I>p</I> == .003 and corrected <I>p</I> == .01). However, the variants of <I>DDR1</I> were not significantly associated with the AERD development (corrected <I>p</I> > .05). On further comparison of FEV<SUB>1</SUB> decline by aspirin provocation between AERD and ATA, the variant <I>rs1264320</I> was found to be associated with the FEV<SUB>1</SUB> decline of ATA rather than AERD. <I>Conclusion.</I> Despite the need for further functional evaluations and replications, we conclude that <I>DDR1</I> polymorphisms are not likely to contribute to predispositions of AERD, but may be potentially associated with FEV<SUB>1</SUB> decline by aspirin provocation in asthmatics.</P>
Putative association of <i>SMAPIL</i> polymorphisms with risk of aspirin intolerance in asthmatics
Yongha Kim, Jason,Kim, Jeong-Hyun,Park, Byng-Lae,Sub Cheong, Hyun,Sook Park, Jong,Soo Jang, An,Uh, Soo-Taek,Choi, Jae-Sung,Kim, Yong-Hoon,Kim, Mi-Kyeong,Choi, Inseon S.,Heon Cho, Sang,Whui Choi, Byoun Informa Healthcare 2010 The Journal of asthma Vol.47 No.9
<P><I>Background.</I> Aspirin-intolerant asthma (AIA), as a clinical syndrome caused by aspirin, is characterized by lung inflammation and reversible bronchoconstriction. Recently, the altered trafficking and diminished airway reactivity have been implicated in allergic airway remodeling. The stromal membrane-associated protein 1-like (SMAP1L) exerts common and distinct functions in vesicle trafficking including endocytosis. The disturbance of pulmonary surfactant synthesis has been elucidated to be associated with asthma experimentally. Moreover, in alveolar type II (ATII) cells that synthesize pulmonary surfactant, alterations of clathrin-dependent endocytosis cause disturbance at the surfactant function, suggesting that SMAP1L, which directly interacts with clathrin, could be associated with asthma and related phenotypes. <I>Objective.</I> To verify our hypothesis that <I>SMAP1L</I> could play a role in the development of AIA, this study investigated associations between single-nucleotide polymorphisms (SNPs) of the <I>SMAP1L</I> gene and AIA. <I>Methods.</I> We conducted an association study between 19 SNPs of the <I>SMAP1L</I> gene and AIA in a total of 592 Korean subjects including 163 AIA and 429 aspirin-tolerant asthma (ATA) patients. Associations between polymorphisms of <I>SMAP1L</I> and AIA were analyzed with sex, smoking status, atopy, and body mass index as covariates. <I>Results.</I> Logistic analyses revealed that three common polymorphisms, <I>rs2982510</I>, <I>rs2294752</I>, and <I>rs446738</I>, were putatively associated with the increased susceptibility to AIA (<I>p</I> = .003, <I>p</I><SUP>corr</SUP> = .004, OR = 0.24, 95% CI = 0.09-0.62 for <I>rs2982510</I> and <I>rs2294752</I>; <I>p</I> = .008, <I>p</I><SUP>corr</SUP> = .03, OR = 0.44, 95% CI = 0.24-0.80 for <I>rs446738</I>, in the recessive model). In addition, <I>rs2982510</I> and <I>rs2294752</I> were significantly associated with the fall of forced expiratory volume in 1 s (FEV<SUB>1</SUB>) by aspirin provocation (<I>p</I> = .001, <I>p</I><SUP>corr</SUP> = .04 in the recessive model for both SNPs). <I>Conclusions.</I> Our findings suggest that <I>SMAP1L</I> might be a susceptible gene to AIA, providing a new strategy for the control of aspirin intolerance.</P>
Serum anti-lysozyme is associated with disease activity of Behiet’s disease
( Jin-su Park ),( Mi-il Kang ),( Jason Jungsik Song ),( Yong-beom Park ),( Soo-kon Lee ),( Chan Hee Lee ),( Sang-won Lee ) 대한내과학회 2015 대한내과학회 추계학술대회 Vol.2015 No.1
Objectives: We investigated the association between autoantibodies against non- myeloperoxidase (MPO) neutrophil granule antigens and activity of Behiet’s disease (BD). Methods: We consecutively enrolled 51 BD patients. We assessed clinical data and BD activity using patients index score of Behiet’s Disease Current Activity Form. And we performed tests for antibodies against proteinase 3 (PR3), MPO, bactericidal permeability increasing protein (BPI), cathepsin G, elastase, lactoferrin and lysozyme. Results: The median patient index score was 2.0, and 56.9% of patients had active BD. In multivariate analysis of variables with significant correlations, only anti-lysozyme showed a significant correlation with BD activity (p=0.002). In multivariate logistic regression analyses of variables, when patients were classified into groups according to the optimal cutoff levels of ESR, CRP and anti-lysozyme (ESR>42.5 mm/hr, CRP>1.35 mg/L and anti-lysozyme>2.95 IU/mL), the variable with independent predictive value was anti-lysozyme (OR 8.384, p=0.015) Conclusions: Anti-lysozyme was significantly correlated with disease activity score and it was only independent value to predict active disease in patients with BD. Furthermore, patients having anti-lysozyme level ≥ 2.95 IU/mL had a significantly higher risk of having active BD than those not.
Kyung Seo Park,Jason Pang,Choigaon Park 한국공공가치학회 2022 공공가치연구 Vol.3 No.1
Purpose: In this technology dense era, the methods of activism have progressed digitally, especially after the start of the COVID-19 pandemic. The developing generation of environmentally conscious individuals utilize digital electronics as the main method of advocacy, resulting in a positive shift in environmental public value worldwide. Method: This paper will analyze the tangible effects of environmental digital activism in Canadian politics, British Columbia’s education institutions, Environmental, Social, Governance (ESG) corporate management, and socially responsible investments (SRI). Conclusion: Conclusively, this paper will provide multidisciplinary recommendations for ongoing sustainable management that can ameliorate ESG practices and digital environmental activism.