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Honokiol exerts dual effects on browning and apoptosis of adipocytes
Lone, Jameel,Yun, Jong Won INSTITUTE OF PHARMCOLOGY POLISH ACADEMY OF SCIENCE 2017 PHARMACOLOGICAL REPORTS Vol.69 No.6
<P>Conclusion: Our findings suggest that honokiol exhibits a modulatory role in adipocytes via induction of browning and apoptosis in white adipocytes, promotion of catabolic lipid metabolism, as well as activation and inhibition of apoptosis in HIB1B brown adipocytes, thereby exhibiting therapeutic potential against obesity. (c) 2017 Institute of Pharmacology, Polish Academy of Sciences. Published by Elsevier Sp. z o.o. All rights reserved.</P>
Magnolol promotes thermogenesis and attenuates oxidative stress in 3T3-L1 adipocytes
Parray, Hilal Ahmad,Lone, Jameel,Park, Jong Pil,Choi, Jang Won,Yun, Jong Won Elsevier 2018 Nutrition Vol.50 No.-
<P><B>Abstract</B></P> <P><B>Objective</B></P> <P>The aim of this study was to explore the browning and antioxidative effects of magnolol in 3T3-L1 adipocytes, as recruitment of beige-like adipocytes (browning) by natural compounds is being considered as a promising strategy to fight against obesity.</P> <P><B>Methods</B></P> <P>Magnolol-induced browning effect was evaluated by determining the expression levels of specific marker genes and proteins using real-time polymerase chain reaction and immunoblotting, respectively. Induction of thermogenesis and suppression of oxidative stress in 3T3-L1 adipocytes were further validated by immunofluorescence.</P> <P><B>Results</B></P> <P>Magnolol significantly enhanced expression of a core set of brown fat–specific marker genes (Ucp1, <I>Cd137, Prdm16, Cidea</I>, and <I>Tbx1)</I> and proteins (UCP1, PRDM16, and PGC-1α). Increased expression of UCP1 and other brown fat–specific markers contributed to the browning of 3T3-L1 adipocytes possibly via activation of the AMPK, PPARγ, and protein kinase A (PKA) pathways. In addition, magnolol up-regulated key fatty acid oxidation and lipolytic markers (CPT1, ACSL1, SIRT1, and PLIN) and down-regulated lipogenic markers (FAS and SREBP1). Magnolol also reduced the production and release of reactive oxygen species.</P> <P><B>Conclusion</B></P> <P>The current data suggest possible roles for magnolol in browning of white adipocytes, augmentation of lipolysis, and thermogenesis, as well as repression of oxidative stress and lipogenesis. Thus, magnolol may be explored as a potentially promising therapeutic agent for the prevention of obesity and other metabolic disorders.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Magnolol exhibits multiple modulatory functions in adipocytes. </LI> <LI> Magnolol prevents 3 T3-L1 adipocytes from oxidative stress. </LI> <LI> Magnolol promotes browning possibly via activation of PPARγ-, pAMPK-, and PKA-mediated pathways. </LI> </UL> </P>
Choi, Minji,Mukherjee, Sulagna,Kang, Nam Hyeon,Barkat, Jameel Lone,Parray, Hilal Ahmad,Yun, Jong Won Wiley Blackwell (John WileySons) 2018 IUBMB life Vol.70 No.6
<P>Induction of the brown adipocyte-like phenotype in white adipocytes (browning) is considered as a novel strategy to fight obesity due to the ability of brown adipocytes to increase energy expenditure. Here, we report that L-rhamnose induced browning by elevating expression levels of beige-specific marker genes, including Cd137, Cited1, Tbx1, Prdm16, Tmem26, and Ucp1, in 3T3-L1 adipocytes. Moreover, L-rhamnose markedly elevated expression levels of proteins involved in thermogenesis both in 3T3-L1 white and HIB1B brown adipocytes. L-rhamnose treatment in 3T3-L1 adipocytes also significantly elevated protein levels of p-HSL, p-AMPK, ACOX, and CPT1 as well as reduced levels of ACC, FAS, C/EBP, and PPAR, suggesting its possible role in enhancement of lipolysis and lipid catabolism as well as reduced adipogenesis and lipogenesis, respectively. The quick technique of efficient molecular docking provided insight into the strong binding of L-rhamnose to the fat-digesting glycine residue of (3)-adrenergic receptor (AR), indicating strong involvement of L-rhamnose in fat metabolism. Further examination of the molecular mechanism of L-rhamnose revealed that it induced browning of 3T3-L1 adipocytes via coordination of multiple signaling pathways through (3)-AR, SIRT1, PKA, and p-38. To the best of our knowledge, this is the first study to demonstrate that L-rhamnose plays multiple modulatory roles in the induction of white fat browning, activation of brown adipocytes, as well as promotion of lipid metabolism, thereby demonstrating its therapeutic potential for treatment of obesity. (c) 2018 IUBMB Life, 70(6):563-573, 2018</P>