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RISS 인기검색어
- 검색키워드
- 저자 : Jalali-Milani, Shahrokh (검색결과 2 건)
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Consolidation deformation of Baghmisheh marls of Tabriz, Iran
Jalali-Milani, Shahrokh,Asghari-Kaljahi, Ebrahim,Barzegari, Ghodrat,Hajialilue-Bonab, Masoud Techno-Press 2017 Geomechanics & engineering Vol.12 No.4
Vast parts of the east of Tabriz city have been covered by Baghmisheh formation marls. These marls can be classified into three types based on their color as identified in yellow, green, and gray marls. Many high-rise buildings and other projects were founded and now is constructing on these marls. Baghmisheh formation marls are classified as stiff soil to very weak rock, therefore they undergo considerable consolidation settlement under foundation loads. This study presents the physical properties and consolidation behavior of these marls. According to the XRD tests, major clay minerals of marls are Illite, Kaolinite, Montmorillonite and Chloride. Uniaxial compressive strength are 100-250, 300-480 and 500-560 kPa for yellow, green and gray marls, respectively. Consolidation and creep behavior of Baghmisheh marls investigated by using of one dimensional consolidation apparatus under stress level up to 5 MPa. The results indicate that yellow marls have high compressibility, settlement and deformation modules. Green marls have an intermediate compressibility and settlement and while gray marls have low compressibility and settlement and from the foundation point of view have high stability. According to the creep test results, all types of marls have not been entered to progressive creep phase up to pressure 5 MPa.
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Hydrogel nanoparticles and nanocomposites for nasal drug/vaccine delivery
Sara Salatin,Jaleh Barar,Mohammad Barzegar-Jalali,Khosro Adibkia,Mitra Alami Milani,Mitra Jelvehgari 대한약학회 2016 Archives of Pharmacal Research Vol.39 No.9
Over the past few years, nasal drug delivery has attracted more and more attentions, and been recognized as the most promising alternative route for the systemic medication of drugs limited to intravenous administration. Many experiments in animal models have shown that nanoscale carriers have the ability to enhance the nasal delivery of peptide/protein drugs and vaccines compared to the conventional drug solution formulations. However, the rapid mucociliary clearance of the drug-loaded nanoparticles can cause a reduction in bioavailability percentage after intranasal administration. Thus, research efforts have considerably been directed towards the development of hydrogel nanosystems which have mucoadhesive properties in order to maximize the residence time, and hence increase the period of contact with the nasal mucosa and enhance the drug absorption. It is most certain that the high viscosity of hydrogel-based nanosystems can efficiently offer this mucoadhesive property. This update review discusses the possible benefits of using hydrogel polymer-based nanoparticles and hydrogel nanocomposites for drug/vaccine delivery through the intranasal administration.
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