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RISS 인기검색어
- 검색키워드
- 저자 : Jaishuen, Atthapon (검색결과 5 건)
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Jaishuen, Atthapon,Kunakornporamat, Kate,Viriyapak, Boonlert,Benjapibal, Mongkol,Chaopotong, Pattama,Petsuksiri, Janjira,Therasakvichya, Suwanit Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.6
Background: To study the incidence of non-endometrioid carcinoma of endometrium and compare the clinical characteristics and treatment outcomes with endometrioid carcinoma patients. Materials and Methods: This study included 236 patients with endometrial carcinoma at Siriraj Hospital whom were diagnosed and treated from 2003 through 2006. The clinical characteristics, pathological features, treatment and clinical outcomes were collected from the medical records. The 5-year survival was calculated according to 2009 FIGO staging. Results: Non-endometrioid carcinoma of endometrium accounted for 10.2% of all endometrial carcinomas (24/236 patients). The 5-year survival rate was significantly lower in the non-endometrioid group compared to the endometrioid group (77.3% vs 96%, p<0.001) and clinical data pointed to greater malignancy. Conclusions: Non-endometrioid carcinoma of endometrium is relative rare but is more aggressive, has more distant metastasis at diagnosis with a worse survival rate than endometrioid carcinoma. Only patients in stage IA with no residual disease on a hysterectomy specimen may not need adjuvant treatment.
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Agreement between Colposcopic Diagnosis and Cervical Pathology: Siriraj Hospital Experience
Tatiyachonwiphut, Molpen,Jaishuen, Atthapon,Sangkarat, Suthi,Laiwejpithaya, Somsak,Wongtiraporn, Weerasak,Inthasorn, Perapong,Viriyapak, Boonlert,Warnnissorn, Malee Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.1
Aim: To evaluate the agreement between colposcopic diagnosis and cervical pathology a retrospective chart review was performed. Materials and Methods: This study included 437 patients who underwent colposcopy and cervical biopsy or conization at Siriraj Hospital from October 2010 - December 2012. The patient clinical characteristics, cervical cytology results, colposcopic diagnoses, cervical pathology results were recorded and correlations between variables were analyzed. Results: Agreement of colposcopic diagnosis and cervical pathology was matched in 253 patients (57.9%). The strength of agreement with weighted Kappa statistic was 0.494 (p<0.001). Colposcopic diagnoses more often overestimated (31.1%) than underestimated (11%) the cervical pathology. Agreement of colposcopic diagnosis and cervical pathology within 1 grade was found in 411 patients (94.1%). Positive predictive value (PPV) of high grade colposcopy or more was 75.5%, whereas the negative predictive value (NPV) of insignificant and low grade colposcopy was 83.8%. False positives of high grade colposcopy or more were 21%. False negatives of insignificant or low grade colposcopy were 19.1%. Conclusions: Strength of agreement between colposcopic diagnosis and cervical pathology was found to be only moderate. A biopsy at colposcopy should be performed at a gold standard level to detect high grade lesions.
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Advanced Imaging Applications for Locally Advanced Cervical Cancer
Petsuksiri, Janjira,Jaishuen, Atthapon,Pattaranutaporn, Pittayapoom,Chansilpa, Yaowalak Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.5
Advanced imaging approaches (computed tomography, CT; magnetic resonance imaging, MRI; $^{18}F$-fluorodeoxyglucose positron emission tomography, FDG PET) have increased roles in cervical cancer staging and management. The recent FIGO (International Federation of Gynecology and Obstetrics) recommendations encouraged applications to assess the clinical extension of tumors rather than relying on clinical examinations and traditional non-cross sectional investigations. MRI appears to be better than CT for primary tumors and adjacent soft tissue involvement in the pelvis. FDG-PET/CT has increased in usage with a particular benefit for whole body evaluation of tumor metabolic activity. The potential benefits of advanced imaging are assisting selection of treatment based upon actual disease extent, to adequately treat a tumor with minimal normal tissue complications, and to predict the treatment outcomes. Furthermore, sophisticated external radiation treatment and brachytherapy absolutely require advanced imaging for target localization and radiation dose calculation.
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Ovarian Cancer in Children and Adolescents: Treatment and Reproductive Outcomes
Chaopotong, Pattama,Therasakvichya, Suwanit,Leelapatanadit, Chairat,Jaishuen, Atthapon,Kuljarusnont, Sompop Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.11
Objective: To review ovarian cancer cases in children and adolescents in Siriraj Hospital and assess the prognosis, recurrence of disease, and reproductive outcomes after treatment. Materials and Methods: A retrospective descriptive study was conducted in ovarian cancer patients 21 years and younger who had been treated at Siriraj Hospital between January 1990 and December 2009. Medical records were reviewed and relevant data were recorded. Results: A total of 48 cases met the criteria; their mean age was 16.4 years. Abdominal distension was the major symptom. 91.6% were germ cell tumors and the remaining cases were sex cord-stromal and epithelial tumors. More than half (25/48 cases) presented with stage I disease. The most common used chemotherapy regimen for germ cell tumors was BEP (bloemycin, etoposide, cisplatin). Most of patients had favorable outcomes; 46/48 cases had complete remission and retained their good health at the time of the review. We had only one recurrent case and one dead case. Ten of contacted patients had married and 3 of them had successful full-term pregnancies. Conclusions: Ovarian malignancy in children and adolescents is a rare disease. The authors reported 48 cases in 20 year-period of work. Most of them have favorable outcomes. Return of ovarian function and fertility are the topics of interest.
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Sompop Kuljarusnont,Janjira Petsuksiri,Pattama Chaopotong,Vuthinun Achariyapota,Pisutt Srichaikul,Atthapon Jaishuen 대한부인종양학회 2016 Journal of Gynecologic Oncology Vol.27 No.5
Objective: To evaluate the recurrence rates and patterns of failure in patients with stage Iendometrial carcinoma after surgical staging without adjuvant therapy. Methods: Medical records of 229 patients with stage I endometrial carcinoma, treated withsurgery alone between 2002 and 2010 at Siriraj Hospital were retrospectively reviewed. Theprimary objective of this study was recurrence rates. The secondary objectives were patternsof failure, disease-free survival, overall survival, and prognostic factors related to outcomes. Results: During median follow-up time of 53.3 months, 11 recurrences (4.8%) occurred witha median time to recurrence of 21.2 months (range, 7.7 to 77.8 months). Vaginal recurrencewas the most common pattern of failure (8/11 patients, 72.7%). Other recurrences werepelvic, abdominal and multiple metastases. Factors that appeared to be prognostic factors onunivariate analyses were age and having high intermediate risk (HIR) (Gynecologic OncologyGroup [GOG] 99 criteria), none of which showed significance in multivariate analysis. Therecurrence rates were higher in the patients with HIR criteria (22.2% vs. 4.1%, p=0.013) orpatients with stage IB, grade 2 endometrioid carcinoma (9.4% vs. 4.3%, p=0.199). Five-yeardisease-free survival and 5-year overall survival were 93.9% (95% CI, 89.9 to 5.86) and 99.5%(95% CI, 97.0 to 99.9), respectively. Conclusion: The patients with low risk stage I endometrial carcinoma had excellentoutcomes with surgery alone. Our study showed that no single factor was demonstrated to bean independent predictor for recurrence.
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