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Cho, S.Y.,Park, J.W.,Liu, Y.,Park, Y.S.,Kim, J.H.,Yang, H.,Um, H.,Ko, W.R.,Lee, B.I.,Kwon, S.Y.,Ryu, S.W.,Kwon, C.H.,Park, D.Y.,Lee, J.H.,Lee, S.I.,Song, K.S.,Hur, H.,Han, S.U.,Chang, H.,Kim, S.J.,Kim Elsevier North Holland [etc.] 2017 Gastroenterology Vol.153 No.2
<P>BACKGROUND & AIMS: Early-onset gastric cancer, which develops in patients younger than most gastric cancers, is usually detected at advanced stages, has diffuse histologic features, and occurs more frequently in women. We investigated somatic genomic alterations associated with the unique characteristics of sporadic diffuse gastric cancers (DGCs) from younger patients. METHODS: We conducted whole exome and RNA sequence analyses of 80 resected DGC samples from patients 45 years old or younger in Korea. Patients with pathogenic germline mutations in CDH1, TP53, and ATM were excluded from the onset of this analysis, given our focus on somatic alterations. We used MutSig2CV to evaluate the significance of mutated genes. We recruited 29 additional early-onset Korean DGC samples and performed SNP6.0 array and targeted sequencing analyses of these 109 early-onset DGC samples (54.1% female, median age, 38 years). We compared the SNP6.0 array and targeted sequencing data of the 109 early-onset DGC samples with those from diffuse-type stomach tumor samples collected from 115 patients in Korea who were 46 years or older (late onset) at the time of diagnosis (controls; 29.6% female, median age, 67 years). We compared patient survival times among tumors from different subgroups and with different somatic mutations. We performed gene silencing of RHOA or CDH1 in DGC cells with small interfering RNAs for cell-based assays. RESULTS: We identified somatic mutations in the following genes in a significant number of early-onset DGCs: the cadherin 1 gene (CDH1), TP53, ARID1A, KRAS, PIK3CA, ERBB3, TGFBR1, FBXW7, RHOA, and MAP2K1. None of 109 early-onset DGC cases had pathogenic germline CDH1 mutations. A higher proportion of early-onset DGCs had mutations in CDH1 (42.2%) or TGFBR1 (7.3%) compared with control DGCs (17.4% and 0.9%, respectively) (P<.001 and P=.014 for CDH1 and TGFBR1, respectively). In contrast, a smaller proportion of early-onset DGCs contained mutations in RHOA (9.2%) than control DGCs (19.1%) (P=.033). Late-onset DGCs in The Cancer Genome Atlas also contained less frequent mutations in CDH1 and TGFBR1 and more frequent RHOA mutations, compared with early-onset DGCs. Early-onset DGCs from women contained significantly more mutations in CDH1 or TGFBR1 than early-onset DGCs from men. CDH1 alterations, but not RHOA mutations, were associated with shorter survival times in patients with early-onset DGCs (hazard ratio, 3.4; 95% confidence interval, 1.5 - 7.7). RHOA activity was reduced by an R5W substitution-the RHOA mutation most frequently detected in early-onset DGCs. Silencing of CDH1, but not RHOA, increased migratory activity of DGC cells. CONCLUSIONS: In an integrative genomic analysis, we found higher proportions of early-onset DGCs to contain somatic mutations in CDH1 or TGFBR1 compared with late-onset DGCs. However, a smaller proportion of early-onset DGCs contained somatic mutations in RHOA than late-onset DGCs. CDH1 alterations, but not RHOA mutations, were associated with shorter survival times of patients, which might account for the aggressive clinical course of early-onset gastric cancer. Female predominance in early-onset gastric cancer may be related to relatively high rates of somatic CDH1 and TGFBR1 mutations in this population.</P>
Hydrogen Behaviors with different introduction methods in SiC-C Films
Huang, N.K.,Zou, P.,Liu, J.R.,Zhang, L. The Korean Vacuum Society 2003 Applied Science and Convergence Technology Vol.12 No.1
SiC-C films were deposited with r. f. magnetron sputtering on substrates followed by argon ion bombardment. These films were then permeated by hydrogen gas under the pressure of $3.23\times10^{7}$ Pa for 3 hours at temperature of 500K or bombarded with hydrogen ion beam at 5 keV and a dose of $1\times10^{18}$ ions/$\textrm{cm}^2$. SIMS, AES and XPS were used to analyze hydrogen related species, chemical bonding states of C, Si as well as contamination oxygen due to hydrogen participation in the SiC-C films in order to study the different behaviors of hydrogen in carbon-carbide films due to different hydrogen introduction. Related mechanism about the effects of hydrogen on the element of the SiC-C films was discussed in this paper.
Hydrogen Behaviors with different introduction methods in SiC - C Films
N. K. Huang,P. Zou,J. R. Liu,L. Zhang 한국진공학회(ASCT) 2003 Applied Science and Convergence Technology Vol.12 No.S1
SiC-C films were deposited with r. f. magnetron sputtering on substrates followed by argon ion bombardment. These films were then permeated by hydrogen gas under the pressure of 3.23×10^7 ㎩ for 3 hours at temperature of 500K or bombarded with hydrogen ion beam at 5 keV and a dose of 1×10^(18) ions/㎠. SIMS, AES and XPS were used to analyze hydrogen related species, chemical bonding states of C, Si as well as contamination oxygen due to hydrogen participation in the SiC-C films in order to study the different behaviors of hydrogen in carbon-carbide films due to different hydrogen introduction. Related mechanism about the effects of hydrogen on the element of the SiC-C films was discussed in this paper.
HIGH-PERFORMANCE Pt/CNTs CATALYSTS VIA HYDROGEN PLASMA FOR METHANOL ELECTROOXIDATION
J. L. XU,S. G. WANG,Q. R. DENG,Y. LIU,J. L. ZHU,C. B. XU,J. H. WANG 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2014 NANO Vol.9 No.2
High-performance carbon nanotubes-supported Pt catalysts (Pt/CNTs) catalysts were pre-pared on the basis of Pt precursors reduced by hydrogen plasma (Pt/CNTs-HP) generated bymicrowave. The other two Pt/CNTs catalysts prepared by hydrogen (Pt/CNTs-H) and NaBH 4(Pt/CNTs-N) reduction were also involved for comparison. The practical composition of thecatalysts was characterized with energy dispersive analysis of X-ray (EDAX). It was shown fromtransmission electron microscopy (TEM) and X-ray di®raction (XRD) that the Pt nanoparticlesin Pt/CNTs-HP were uniformly dispersed on CNTs with smaller particle size around 2 nmand narrower size distribution as compared with the other two catalysts. Additionally, X-rayphotoelectron spectrum (XPS) analysis indicated higher amount of zero-valence states of Pt inPt/CNTs-HP caused by hydrogen plasma treatment. The electrooxidation of liquid methanol onthese catalysts was investigated by cyclic voltammetry (CV), linear sweep voltammetry (LSV)and chronoamperometry. The long-time durability is very comparable to all the three catalysts. Remarkably, the Pt/CNTs-HP possessed the highest electrocatalytic activity, suggesting thatthe hydrogen plasma reduction approach can be a promising reduction method for preparinghigh-performance Pt-based electrocatalysts.
R.S. Liu,T.S. Chan,S. Mylswamy,G.Y. Guo,J.M. Chen,J.P. Attfield 한국물리학회 2008 Current Applied Physics Vol.8 No.1
The chemical pressure control in (Sr2. xCax)FeMoO6 (06 x 6 2.0) with double perovskite structure has been investigated systemat-x = 0 and x = 2.0. The increasing Ca con-tent in (Sr2. xCax)FeMoO6 samples increases the magnetic moment close to the theoretical value due to reduction of Fe/Mo anti-sitedisorder. An increasing Ca content results in increasing (Fe2+ +Mo6+)/(Fe3+ +Mo5+) band overlap rather than bandwidth changes.This is explained from simple ionic size arguments and is supported by X-ray absorption near edge structure (XANES) spectra and bandstructure calculations.