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New Butyrylcholinesterase Inhibitory Steroid and Peroxy Acid from Leucas urticifolia
Fatima, Itrat,Ahmad, Ijaz,Anis, Itrat,Malik, Abdul,Afza, Nighat,Iqbal, Lubna,Latif, Mehreen 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.8
A new steroid leucisterol (1) and a new peroxy acid urticic acid (2) along with methoxybenzyl benzoate (3), 4-hydroxy benzoic acid (4), $\beta$-sitosterol (5), and ursolic acid (6), have been isolated from the chloroform soluble fraction of the whole plant of Leucas urticifolia. Their structures were elucidated on the basis of nuclear magnetic resonance (1D and 2D NMR) spectral data. Leucisterol showed potent inhibitory activity against butyrylcholinesterase enzyme.
Purunusides A-C, α-Glucosidase Inhibitory Homoisoflavone Glucosides from Prunus domestica
Shaheen Kosar,Itrat Fatima,Azhar Mahmood,Rehana Ahmed,Abdul Malik,Muhammad Iqbal Chouhdary,Sumaira Talib 대한약학회 2009 Archives of Pharmacal Research Vol.32 No.12
Purunusides A-C (1-3), new homoisoflavone glucosides together with the known compounds β-sitosterol (4) and 6,7-methylenedioxy-8-methoxycoumarin (5) have been isolated from nbutanol and ethyl acetate soluble fractions of Prunus domestica. Their structures were assigned on the basis of spectral studies. The compounds 1-3 showed potent inhibitory activity against the enzyme α-glucosidase.
New antimicrobial flavonoids and chalcone from Colutea armata
Farah Inamullah,Itrat Fatima,Sadia Khan,Mehdi Hassan Kazmi,Abdul Malik,Rasool Bakhsh Tareen,Tanveer Abbas 대한약학회 2017 Archives of Pharmacal Research Vol.40 No.8
Colucins A (1) and B (2), new flavonoids andcolucone (3), the new chalcone derivative, have been isolatedfrom the CHCl3-soluble fraction of the whole plant ofColutea armata along with luteolin (4), luteolin 7-O-b-Dglucoside(5), isoliquiritigenin (6), trans-caffeic acid (7)and stigmasterol (8) reported for the first time from thisspecies. Their structures were elucidated by spectroscopictechniques including MS and 2D-NMR spectroscopy. Compounds 1 and 2 showed significant antimicrobialactivity against two Gram positive and three Gram negativebacterial strains while 3 was moderately active.
Ophiamides A-B, New Potent Urease Inhibitory Sphingolipids from Heliotropium ophioglossum
Sadiqa Firdous,Abdul Malik,Nida Hassan Ansari,Itrat Fatima,Nighat Afza,Lubna Iqbal,Mehreen Lateef 대한약학회 2012 Archives of Pharmacal Research Vol.35 No.7
Ophiamides A (1) and B (2), two new sphingolipids have been isolated from the n-hexane subfraction of the MeOH extract of the whole plant of Heliotropium ophioglossum along with glycerol monopalmitate (3) and β-sitosterol 3-O-β-D-glucoside (4) reported for the first time from this species. Their structures were elucidated by spectroscopic techniques including MS and 2D-NMR spectroscopy. Both the compounds 1 and 2 showed potent inhibitory activity against the enzyme urease.