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Major Depressive Disorder With Anger Attacks and Subcortical MRI White Matter Hyperintensities
Iosifescu, Dan V.,Renshaw, Perry F.,Dougherty, Darin D.,Lyoo, In Kyoon,Lee, Ho Kyu,Fraguas, Renerio,Cassano, Paolo,Nierenberg, Andrew A.,Fava, Maurizio Lippincott Williams Wilkins, Inc. 2007 The Journal of nervous and mental disease Vol.195 No.2
Previous reports of increased rates of cardiovascular risk factors in major depressive disorder (MDD) with anger attacks led the authors to hypothesize that MDD with anger attacks may be associated with brain vascular changes (magnetic resonance imaging white matter hyperintensities [WMHs]). Sixty-five subjects meeting DSM-III-R criteria for major depressive disorder were administered brain magnetic resonance imaging scans at 1.5T to detect T2 WMH. The severity of brain WMH was classified with the Fazekas scale. We used standardized scales to assess melancholic MDD, atypical MDD, and MDD with anger attacks. In logistic regression analyses, MDD with anger attacks was associated with higher severity of subcortical WMH and of total WMH, but not with periventricular WMH. Atypical and melancholic MDD subtypes were not significantly associated with brain WMH. In conclusion, subcortical brain vascular lesions may be more prevalent or severe in MDD with anger attacks.
A glimpse to the resident life in a hepato-biliary-pancreatic team
Mara MARDARE,Alina PUSCASU,Victor BURLOIU,Andrei VACARASU,Irina BONDOC,Andrada SPANU,Razvan IOSIFESCU,Marius ZAMFIR,Niculae IORDACHE,Octav GINGHINA,Radu GHENADE,Camelia CALIN 한국간담췌외과학회 2021 Annals of hepato-biliary-pancreatic surgery Vol.25 No.-