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Kim, Injung,Park, Jongkeun,Kim, Jeong-Ki,Kim, Bong-Kyu,Lee, Hwayoung,Choi, Keonwoo,Yoon, Jong-Bok,Yoon, Sungjoo Kim Springer-Verlag 2014 Genes & Genomics Vol.36 No.3
T-cadherin is frequently down regulated in various cancers, however, the underlying mechanisms responsible have yet to be elucidated. A genome wide association study of a cohort of Korean adults revealed that the T-cadherin rs3865188 single nucleotide polymorphism (SNP) was associated with serum Adiponectin levels and that its genotypic variants were correlated with risk for colorectal cancer (CRC). To test the function of rs12444338, a SNP tightly linked to the rs3865188 SNP, in T-cadherin transcriptional regulation in colorectal cancer, its effect on transcriptional activity and the capacity of binding activity attributable to allelic variation of the rs12444338 SNP was investigated. An electrophoretic-mobility-shift assay (EMSA) revealed a specific nucleoprotein complex unique to the T allele probe, which displayed lower promoter activity when compared to the G allele. Based on the results of the EMSA using mutant probes, the consensus sequence of the putative transcription factor binding site was determined. Additionally, candidates for putative binding factors to the T allele were also identified. Collectively, the study data suggested that the rs12444338 SNP was involved in transcriptional regulation of T-cadherin gene (CDH13) and that the differential binding of transcription factors at the rs12444338 SNP resulted in altered gene expression. These results elucidate, at least in part, the regulation of T-cadherin expression in CRC and provide further information regarding the effect of nucleotide variation in its promoter region.
Injung Kim,Kyeongjin Kim,Sungjin Lee,Kwang W. Kim 한국도로학회 2018 한국도로학회 학술대회 발표논문 초록집 Vol.2018 No.05
There are some places such as bridges in the heavily industrialized area where the pavement should have a strong resistance against heavy axle loading and waterproof function. In those places, many polymer-modified asphalt (PMA) pavements were applied to protect premature cracking, severe rutting and water intrusion without success. Therefore, a much tougher pavement material with waterproofing function was developed for those places. This study evaluated important properties of the special type asphalt mixture which is highly condensed to be almost void-free condition. A high-quality PMA binder with PG82-34 grade was used for preparing the mixture and the optimum binder content was determined to allow near 0% air void in the mix design. The deformation strength(SD) by Kim Test and rut depth by wheel tracking test were measured at 60℃ as high temperature properties. The flexural strength and fracture toughness was measured at -10℃ as low temperature property. The void-free AC showed the higher performance in all four properties than any other asphalt concretes which were prepared for comparison. Therefore, it was shown that the normal concern about limiting air voids within 3-5% was just an apprehension. The void-free AC can be applied for heavy duty pavement on the bridge where the water-proofing function and higher rutting and cracking resistance are required.
Kim, Jihee,Choi, Seungse,An, Injung,Lee, Seunghyuk,Lee, Eun Ju,You, Young-Han,Kim, Baek-Jun,Han, Donguk,Park, Sangkyu,Joo, Sungbae National Institute of Ecology 2021 국립생태원회보(PNIE) Vol.2 No.3
Hulunbuir steppe, one of the four largest steppes in China, has experienced rapidly progressing desertification partly due to overgrazing by livestock. The objective of this study was to investigate the effectiveness of various vegetation recovery methods, including the selection of unpalatable plants less affected by grazing livestock. To determine livestock grazing preferences at Hulunbuir restoration sites, we used DNA barcoding methods to analyze fecal materials of horses and cattle grazing on four restored plants: two trees (Pinus sylvestris L. var. mongolica and Populus canadensis) and two shrubs (Caragana microphylla and Corethrodendron fruticosum). Neither of the two tree species were detected in livestock feces, whereas both shrub species were detected at lo w frequencies. There were no significant differences in compositions of species consumed by horses and cattle except that Asteraceae species were more often consumed by cattle. Our results showed that the four plants used for restoration may be classified as unpalatable or less palatable species in the Hulunbuir restoration area. Our results may help inform restoration strategies implemented in restoration areas, especially regarding negative effects of livestock grazing during the initial stage of restoration in Hulunbuir.
SCADA 시스템과 정보망의 연동을 위한 위험분석 연구
김인중 ( Injung Kim ),정윤정 ( Yoonjung Jung ),민병길 ( Byeonggil Min ),박중길 ( Joongil Park ) 한국정보처리학회 2004 한국정보처리학회 학술대회논문집 Vol.11 No.1
최근 SCADA 시스템은 국가기반시설의 중요한 시스템으로 인식됨에 따라 사이버상의 침해사고 대응 및 복구대책이 요구되고 있다. 일반적으로 기존에는 SCADA 시스템 설계시 공정 절차에 따라 이식성, 확장성, 가용성, 유연성을 고려하였으나 최근 안전하고 신뢰성있는 시스템 운영을 위하여 보안에 많은 관심을 갖게 되었다. 본 논문에서는 SCADA 시스템에 대한 보안 설계에 필요한 위험분석 절차를 제시함으로써 사이버테러에 의하여 발생될 국가적 재난·재해를 사전에 예방하고자 한다.