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Development of Stiffness Analysis Program for Automotive Wheel Bearing
Inha Lee(이인하),Younggeol Cho(조영걸),Jungho An(안정호),Youngmin Cho(조영민),Munsung Kim(김문성),Cheonsoo Jang(장천수),Younghwan Lee(이영환),Seungpyo Lee(이승표) 한국자동차공학회 2012 한국자동차공학회 부문종합 학술대회 Vol.2012 No.5
Automotive wheel bearing is an essential component of the vehicle and transmits engine power into wheels and supports vehicle weight. As comfortable ride has recently been the common interest, the stiffness of bearing which affects the steering performance becomes significant. In this study, the program BSAP was developed to carry out the stiffness analysis by designer easily and quickly. BSAP has three templates; CATIA template, AFC template, and Report template. In CATIA template, 3D analysis model was generated from the CAD model by eliminating useless fillets and holes and assigning heat treatment parts. Material property, boundary conditions and loadings were applied and analysis was performed in AFC template. Finally, analysis results were reported automatically in Report template. Bearing stiffness analysis was performed by using the BSAP. To verify the reliability of BSAP, the analysis results were compared with experiment results. They showed good agreement with the experiment results.
( Inha Lee ),( Young Bin Won ),( Jisun Yun ),( Jae Hoon Lee ),( Seok Kyo Seo ),( Si Hyun Cho ),( Young Sik Choi ),( Byung Seok Lee ),( Bo-hyon Yun ) 대한산부인과학회 2018 대한산부인과학회 학술대회 Vol.104 No.-
Objective: Thioredoxin (TRX) is a redox regulating antioxidant protein that prevents cell damage from oxidative stress and TRX binding protein(TBP)-2 are regulatory protein of TRX. Altered TRX and TBP-2 expressions in endometrium are known to be associated with the development of endometriosis. The aim of the study was to identify a role of Histone deacetylase inhibitor (HDACi) in human endometrial cells, by modifying TRX and TBP-2 expression. Methods: From July, 2015 to June, 2016, eutopic and ectopic endometrium was obtained from the patients who had undergone hysterectomy and ovarian cyst enucleation due to endometriosis respectively. The cultured human endometrial stromal cells (HESCs) and ishikawa cells were treated with HDACi (suberoylanilide hydroxamic acid, SAHA). After inducing cell inflammation adding oxidative stress on the cells, SAHA treatment and following changes of cell proliferation, viability and TRX, TBP-2 expression were examined. Inflammatory cytokines including Interleukin (IL)-1, IL-6, IL-10 and Tumor necrosis factor- were measured from the supernatants of the cultured cell treated with SAHA. Results: Expression of TBP-2 was significantly increasing according to the increase of SAHA concentration in eutopic, ectopic endometrial stromal cell and ishikawa cell. Cell proliferation was shown according to the recombinant high mobility group box(rHMGB)-1 treatment in cultured ectopic, eutopic endometrial cells. Expression of TBP-2 was significantly decreased after inducing oxidative stress by rHMGB-1 on the endometrial cells, which recovery was shown by treating SAHA, resulting in TBP-2 increase and decreased TRX/TBP-2 ratio. Inflammatory cytokine secretion was decreased according to the SAHA treatment by concentration in endometrial cells. Conclusion: SAHA may affect the inflammation induced by oxidative stress in development of endometriosis, via resuming the TRX and TBP-2 expression, leading a potential treatment option in endometriosis. Acknowledgements: This study was supported by a faculty research grant of Yonsei University College of Medicine for 6-2015-0073.
( Inha Lee ),( Young Bin Won ),( Heeyon Kim ),( Jae Hoon Lee ),( Bo Hyon Yun ),( Seok Kyo Seo ),( Sihyun Cho ),( Byung Seok Lee ),( Young Sik Choi ) 대한산부인과학회 2019 대한산부인과학회 학술대회 Vol.105 No.-
Objective: Emerging evidence suggests that several cytokines support embryonic development, protecting blastomeres from cell stress and apoptosis, promoting implantation. Therefore, possible correlations between embryo quality and the concentrations of specific cytokines in the culture medium of human embryos have been explored for many years. The aim of this study was to assess the levels of variety of cytokines in culture medium of preimplantation embryos and to investigate their relationship with embryo quality and in vitro fertilization (IVF) outcomes. Methods: A total of 75 samples were obtained from 31 infertile couples undergoing either IVF or ICSI treatment between August 2018 and May 2019. Each embryo was cultured separately, and embryo culture media was collected 72 hours after fertilization. The cytokine concentrations of each culture media were analyzed for 23 selected cytokines using Multiplex cytokine/chemokine panel II (Merck Millipore®). Prior to day 3 embryo transfer, morphological evaluation of each embryo was performed and categorized into two groups (top quality and non-top). Results: The median age of 31 patients was 34 years old (range:25-39). Thirteen cytokines resulted in out of range data due to small sample volume; therefore, 10 out of 23 cytokines were quantified and compared between top quality embryo group and non-top quality embryo group. Among 10 cytokines, Chemokine ligand (CCL)-8, CCL-13, CCL-15, CCL-27, and CXCL-12 were significantly elevated in top embryo group. Conclusion: Our results suggest that specific cytokines that are measured from human embryo culture medium can serve as a potential tool for predicting embryo quality and IVF outcomes.
Salt Induces Adipogenesis/Lipogenesis and Inflammatory Adipocytokines Secretion in Adipocytes
Lee, Myoungsook,Sorn, Sungbin Richard,Lee, Yunkyoung,Kang, Inhae MDPI 2019 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol.20 No.1
<P>It is well known that high salt intake is associated with cardiovascular diseases including hypertension. However, the research on the mechanism of obesity due to high salt intake is rare. To evaluate the roles of salt on obesity prevalence, the gene expression of adipogenesis/lipogenesis and adipocytokines secretion according to adipocyte dysfunction were investigated in salt-loading adipocytes. High salt dose-dependently increased the expression of adipogenic/lipogenic genes, such as <I>PPAR-γ, C/EBPα</I>, <I>SREBP1c, ACC, FAS,</I> and <I>aP2</I>, but decreased the gene of lipolysis like <I>AMPK</I>, ultimately resulting in fat accumulation. With SIK-2 and Na<SUP>+</SUP>/K<SUP>+</SUP>-ATPase activation, salt increased the metabolites involved in the renin-angiotensin-aldosterone system (RAAS) such as <I>ADD1, CYP11β2,</I> and <I>MCR.</I> Increasing insulin dependent insulin receptor substrate (IRS)-signaling, resulting in the insulin resistance, mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) and Akt-mTOR were activated but AMPK(Thr<SUP>172</SUP>) was depressed in salt-loading adipocytes. The expression of pro-inflammatory adipocytokines, TNFα, MCP-1, COX-2, IL-17A, IL-6, leptin, and leptin to adiponectin ratio (LAR) were dose-dependently increased by salt treatment. Using the inhibitors of MAPK/ERK, U0126, we found that the crosstalk among the signaling pathways of MAPK/ERK, Akt-mTOR, and the inflammatory adipogenesis can be the possible mechanism of salt-linked obesity. The possibilities of whether the defense mechanisms against high dose of intracellular salts provoke signaling for adipocytes differentiation or interact with surrounding tissues through other pathways will be explored in future research.</P>
Effect of particulate matter on endometriosis
( Inha Lee ),( Heeyon Kim ),( Bo Hee Won ),( Hye In Kim ),( So Hyun Ahn ),( Yun Jeong Park ),( Hae Won Baek ),( Jae Hoon Lee ),( Bo Hyon Yun ),( Seok Kyo Seo ),( Young Sik Choi ),( Sihyun Cho ),( Byun 대한산부인과학회 2020 대한산부인과학회 학술대회 Vol.106 No.-
Objective: Endometriosis is a common gynecologic disorder that is characterized by chronic pelvic pain, dysmenorrhea, and infertility. Although the adverse effects of particulate matter on the human body and many diseases are proven, studies of the effects on endometriosis and related infertility are insignificant not only in Korea but around the world. The object of this study is to evaluate the effect of the particulate matter on the endometrium of the endometriosis compared to controls. Methods: During the surgery, endometrial tissues in patients with and without endometriosis were obtained under informed consent. Benign ovarian cysts without endometriosis were served as controls. Each endometrium of the endometriosis and control cells were treated with 400ug of the urban particulate matter(SRM 1648a). Cell Counting Kit-8 (CCK-8) was used to determinate the cell viability. After protein extractions, expression levels of four cell signaling molecules related to apoptosis, caspase3, BAX, Bcl-2, and p53 were evaluated by using western blot. Results: After treating the particulate matter, cell viability was decreased in endometrium of both endometriosis and controls, with significanlty higher decrease rate in endometriosis group. Also, Expression of Caspase3, BAX, p53 was lower in eutopic endometrium of endometriosis compared to controls while Bcl-2 was higher in endometriosis. When particulate matter was applied, all protein levels in eutopic endometrium of the controls were decreased, while the decrease tendency was not definite in the endometrium of the endometriosis group. Conclusion: Particulate matter affects the cell proliferation and apoptosis of the endometrium cells by altering the cell signaling molecules. The effect of particulate matter was different in endometriosis group compared with control group and endometriosis might have reseistance in particulate matter.