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Choi, Il-Dong,Ryu, Ju-Hee,Lee, Dong-Eun,Lee, Myoung-Hee,Shim, Jae-Joong,Ahn, Young-Tae,Sim, Jae-Hun,Huh, Chul-Sung,Shim, Wang-Seob,Yim, Sung-Vin,Chung, Eun-Kyoung,Lee, Kyung-Tae Hindawi Publishing Corporation 2016 Evidence-based Complementary and Alternative Medic Vol.2016 No.-
<P>To evaluate the pharmacokinetics of compound K after oral administration of HYFRG and RG in humans, an open-label, randomized, single-dose, fasting, and one-period pharmacokinetic study was conducted. After oral administration of a single 3 g dose of HYFRG and RG to 24 healthy Korean males, the mean (±SD) of AUC<SUB>0–<I>t</I></SUB> and <I>C</I><SUB>max</SUB> of compound K from HYFRG were 1466.83 ± 295.89 ng·h/mL and 254.45 ± 51.20 ng/mL, being 115.2- and 80-fold higher than those for RG (12.73 ± 7.83 ng·h/mL and 3.18 ± 1.70 ng/mL), respectively; in case of Sprague Dawley rats the mean (±SD) of AUC<SUB>0–<I>t</I></SUB> and <I>C</I><SUB>max</SUB> of compound K from HYFRG was 58.03 ± 32.53 ng·h/mL and 15.19 ± 10.69 ng/mL, being 6.3- and 6.0-fold higher than those from RG (9.21 ± 7.52 ng·h/mL and 2.55 ± 0.99 ng/mL), respectively. <I>T</I><SUB>max</SUB> of compound K in humans and rats was 2.54 ± 0.92 and 3.33 ± 0.50 h for HYFRG and 9.11 ± 1.45 and 6.75 ± 3.97 hours for RG, respectively. In conclusion, the administration of HYFRG resulted in a higher and faster absorption of compound K in both humans and rats compared to RG.</P>