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Control Elements and Factors in Eukaryotic DNA Replication
( E . Fanning,W . Traut,M . Hartl,P . Alliger,I . Dornreiter,E . Carstens,I . Moarefi ) 한국유전학회 1988 Genes & Genomics Vol.10 No.4
Replication of simian virus 40 (SV40) DNA is controlled by a 64 base-pair viral DNA sequence which serves as the origin of DNA replication, the viral protein T-antigen, which binds to the origin DNA and is required for initiation of each round of replication, and by so far unknown protein(s) provided by the primate host cell. We have recently identified and purified a monkey cell factor (MCF) that binds specifically to DNA sequences in the SV40 origin of replication. MCF also binds to single-stranded DNA and associates with the cellular DNA polymerase alpha. Binding activity of MCF on mutant origin templates is correlated with replication activity of the mutant origins in vivo. The role of MCF in SV40 DNA replication in vitro, binding of MCF to putative cellular origins of replication, and the nature of putative cellular termination sequences are under investigation.