http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Kim, Myeong Seop,Ryu, HyungChul,Kang, Dong Wook,Cho, Seong-Hee,Seo, Sejin,Park, Young Soo,Kim, Mi-Yeon,Kwak, Eun Joo,Kim, Yong Soo,Bhondwe, Rahul S.,Kim, Ho Shin,Park, Seul-gi,Son, Karam,Choi, Sun,DeA American Chemical Society 2012 Journal of medicinal chemistry Vol.55 No.19
<P>A series of <I>N</I>-(2-amino-6-trifluoromethylpyridin-3-ylmethyl)-2-(3-fluoro-4-methylsulfonylaminophenyl)propanamides were designed combining previously identified pharmacophoric elements and evaluated as hTRPV1 antagonists. The SAR analysis indicated that specific hydrophobic interactions of the 2-amino substituents in the C-region of the ligand were critical for high hTRPV1 binding potency. In particular, compound <B>49</B><I><B>S</B></I> was an excellent TRPV1 antagonist (<I>K</I><SUB>i(CAP)</SUB> = 0.2 nM; IC<SUB>50(pH)</SUB> = 6.3 nM) and was thus approximately 100- and 20-fold more potent, respectively, than the parent compounds <B>2</B> and <B>3</B> for capsaicin antagonism. Furthermore, it demonstrated strong analgesic activity in the rat neuropathic model superior to <B>2</B> with almost no side effects. Compound <B>49</B><I><B>S</B></I> antagonized capsaicin induced hypothermia in mice but showed TRPV1-related hyperthermia. The basis for the high potency of <B>49</B><I><B>S</B></I> compared to <B>2</B> is suggested by docking analysis with our hTRPV1 homology model in which the 4-methylpiperidinyl group in the C-region of <B>49</B><I><B>S</B></I> made additional hydrophobic interactions with the hydrophobic region.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jmcmar/2012/jmcmar.2012.55.issue-19/jm300780p/production/images/medium/jm-2012-00780p_0014.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/jm300780p'>ACS Electronic Supporting Info</A></P>
Kim Ga Hee,Park Hyungchul,Jung Kee Wook,Kim Min-Ju,Kim Ye-Jee,Lee Ji Min,Lee Bong Eun,Min Yang Won,Kim Jeong Hwan,Na Hee Kyong,Ahn Ji Yong,Lee Jeong Hoon,Kim Do Hoon,Choi Kee Don,Song Ho June,Lee Gin 거트앤리버 소화기연관학회협의회 2023 Gut and Liver Vol.17 No.6
Background/Aims: Although an association between achalasia and esophageal cancer has been reported, whether achalasia confers a substantial increase in mortality is unknown. Moreover, the causes of death related to achalasia have not been investigated. We performed this nationwide, population-based cohort study on achalasia because no such study has been performed since the introduction of high-resolution manometry in 2008. Methods: This study was performed using data extracted from the Korean National Health Insurance Service database, covering a 9-year period from 2009 to 2017. Control participants without a diagnostic code for achalasia were randomly selected and matched by sex and birth year at a case-to-control ratio of 1:4. Data on the cause of death from Statistics Korea were also analyzed. Results: The overall incidence of achalasia was 0.68 per 100,000 person-years, and the prevalence was 6.46 per 100,000 population. Patients with achalasia (n=3,063) had significantly higher adjusted hazard ratio (aHR) for esophageal cancer (aHR, 3.40; 95% confidence interval [CI], 1.25 to 9.22; p=0.017), pneumonia (aHR, 2.30; 95% CI, 1.89 to 2.81; p<0.001), aspiration pneumonia (aHR, 3.92; 95% CI, 2.38 to 6.48; p<0.001), and mortality (aHR, 1.68; 95% CI, 1.44 to 1.94; p<0.001). Esophageal cancer carried the highest mortality risk (aHR, 8.82; 95% CI, 2.35 to 33.16; p=0.001), while pneumonia had the highest non-cancer mortality risk (aHR, 2.28; 95% CI, 1.31 to 3.96; p=0.004). Conclusions: In this nationwide study, achalasia was associated with increased risk of mortality. Esophageal cancer and pneumonia were the most common comorbidities and the major causes of death in patients with achalasia.
철도전기실의 초박형 액체단열재 적용을 통한 에너지 절감효과
김형철(Hyungchul Kim),장정훈(Junghoon Jang),신승권(Sungkwon Shin),박용섭(Yongsub Park),김상암(Sangam Kim),김형래(Hyeong Rae kim),현병수(Byungsoo Hyun),김진호(Jinho Kim) 대한전기학회 2015 전기학회논문지 Vol.64 No.1
In this paper, because of global environmental problems such as energy shortage and abnormal climate, green energy development and energy saving technology development is being magnified. Heat insulation, the most basic and traditional energy saving method, is highly expected. Especially, simple and advanced heat insulation technique based on Nano material is promising future technology. The railway system also requires heat insulation. Especially, traditional heat insulator such as glass wool has been adopted frequently to rolling stock. The heat insulator is also adopted in general railway service buildings. Take account of cost-effective heat blocking performance, the heat insulator shall be adopted in diverse fields such as electric power, railroad, signal and communication. The only and direct solution for this problem is installing heat insulator with outstanding endurance, corrosion resistance and heat resistance to block outer heat Upgrading heat specification of equipment can be a solution, but since price and maintenance cost rise severely, this plan might be incongruous. In this research, energy saving effect of ultrathin heat insulator film was demonstrated by installing the film on roof of electrical room.
CMOS passive wake-up circuit for sensor network applications
Kim, Hyungchul,Cho, Hanjin,Xi, Yao,Kim, Minsu,Kwon, Sungwook,Lim, Joonhyung,Yang, Youngoo Wiley Subscription Services, Inc., A Wiley Company 2010 MICROWAVE AND OPTICAL TECHNOLOGY LETTERS Vol.52 No.3
<P>A passive wake-up circuit with high-voltage sensitivity using standard CMOS technology has been designed and implemented.Voltage multipliers and inverter chain optimized for high-voltage sensitivity have been proposed. A radio identification scheme to make peer-to-peer communication has also been proposed. The wake-up circuit converts small-RF input signals into a DC signal to trigger the interrupt. A duty cycle scheduling is adopted for an advanced power control. Using an RF input signal, whose center frequency is 870 MHz and input power is −29.3 dBm, we achieved an output voltage of 0.7 V, enough to trigger on the output. The fully integrated CMOS IC is fabricated using a 0.18-μm standard CMOS process. The chip area is as small as 230 × 190 μm<SUP>2</SUP>. © 2010 Wiley Periodicals, Inc. Microwave Opt Technol Lett 52: 597–600, 2010; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.24982</P>
A New Concept of Power Flow Analysis
Hyungchul Kim,Nader Samann,Donggeun Shin,Byeonghun Ko,Gilsoo Jang,Junmin Cha 대한전기학회 2007 Journal of Electrical Engineering & Technology Vol.2 No.3
The solution of the power flow is one of the most important problems in electrical power systems. These traditional methods such as Gauss-Seidel method and Newton-Raphson (NR) method have had drawbacks up to now such as initial values, abnormal operating solutions and divergences in heavy loads. In order to overcome theses problems, the power flow solution incorporating genetic algorithm (GA) is introduced in this paper. General operator of genetic algorithm, arithmetic crossover, and non-uniform mutation operator of GA are suggested to solve the power flow problem. While abnormal solution cannot be obtained by a NR method, multiple power flow solution can be obtained by a GA method. With a heavy load, both normal solution and abnormal solution can be obtained by a proposed method. In this paper, a floating number representation instead of the binary number representation is introduced for accuracy. Simulation results have been compared with traditional methods.
The Study of FACTS Impacts for Probabilistic Transient Stability
Hyungchul Kim,Sae-Hyuk Kwon 대한전기학회 2006 Journal of Electrical Engineering & Technology Vol.1 No.2
This paper proposes a probabilistic evaluation for the transient stability of electrical power systems incorporating FACTS devices. The uncertainties of the fault location and relay operation time play important keys in power system instability evaluation. The TCSC and SVC are employed for the reduction of system instability probability. This method is demonstrated by the WSCC test system and the results are compared with and without FACTS by means of Monte Carlo simulation.