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Computational fluid dynamics of NiTi stents for Cerebral Aneurysm prevention
Hyo-Geun Nam(남효근),Chang-Min.Yoo(유창민),Jae-Hee Shin(신재희),Min-Ho Hwang(황민호),Seung-Min Baek(백승민),Jung-Hoon Park(박정훈),Jin-Su Jeong(정진수),Jae-Won Lee(이재원),Hyuk Choi(최혁) 대한전자공학회 2016 대한전자공학회 학술대회 Vol.2016 No.6
Stents are significant medical devices broadly used in the prevention of cerebral aneurysm rupture. The performance of stents depends on their mechanical properties and cell configuration, thus, the aim of this study is the optimization of stent design and test the hemodynamic properties by using computational solid mechanics and computational fluid dynamics. In performance tests, computer-based cerebral aneurysm models of human brain were tested. closed-cell type was selected as the strut configuration, and nitinol was chosen as the material due to its flexibility. Three types of ideal samples with different cell configurations were manufactured. There were over 30% difference in results of flexibility in computational solid mechanics analysis. Moreover, in cerebral aneurysm model simulation, we investigated that stent insertion eased the hemodynamic factors of the cerebral aneurysm and reduced the flow velocity influx into the sac. A reduction in flow velocity led to a 50–60% reduction in wall shear stress, which is expected to aid aneurysm rupture prevention under clinical conditions.
다결정 다이아몬드 필름의 신경종양세포(SH-SY5Y) 배양 특성
남효근(Hyo-Geun Nam),오홍기(Hong-Gi Oh),김대훈(Dae-Hoon Kim),김민혜(Min-Hye Kim),박혜빈(Hye-Bin Park),지광환(Kwang-Hwan Jhee),송광섭(Kwang-Soup Song) 한국기계가공학회 2013 한국기계가공학회지 Vol.12 No.4
In order to fabricate high sensitive and stable biosensors, we require the material with superior biocompatibility and physical-chemical stability. Many kinds of biomaterials have been evaluated to apply for bioindustry. Recently, carbon based diamond thin films have been focal pointed as bio-applications and their possibility has been evaluated. Diamond thin film has many advantages for electrochemical and biological applications, such as wide potential window (3.0~3.5V), low background current and chemical-physical stability. In this work, we have cultured neuroblastoma cell (SH-SY5Y) on the crystalline diamond films. We use MTT assay to evaluate the characteristic of cell culture on the substrates. As a result, neuroblastoma cell was cultured on the crystalline diamond film as similar as cell culture dish.
Stabilization of the surface of nitinol stent for cerebral aneurysm prevention
Chang-Min.Yoo(유창민),Hyo-Geun Nam(남효근),Je-Hee Shin(신재희),Min-Ho Hwang(황민호),Seung-Min Baek(백승민),Hyeong-Guk Son(손형국),Jeong-Hun Park(박정훈),Jin-Su Jeong(정진수),Jae-Won Lee(이재원),Hyuk Choi(최혁) 대한전자공학회 2016 대한전자공학회 학술대회 Vol.2016 No.6
Nikel titanium shape memory alloys (NiTi) are promising materials due to their shape memory effect. The disadvantage of the nickel is the toxicity, there are too many restrictions on the use of the human body. Hence, if the proper surface modification is chosen, the surface of NiTi can be tranquilized and smooth. Also, toxic chemicals can be protected by oxide film. The polishing method we have used is electro-polishing which is simple enough, economical and can handle wide range at once. In this study, we are surface modification NiTi by surface electro-polishing. The polishing method we have used is electro-polishing which is simple enough, economical and can handle wide range at once. We have used AFM(atomic force microscopy), SEM(scanning electron microscopy), OM(optical microscope) to analyze the roughness, and formation of surface of NiTi stent. To measure corrosion resistance, steady potentiostat was used to corrosion test. Our study group have concluded that condition of 40V 10seconds of electro-polishing showed the optimal stabilization of the surface.
The micro-current stimulation system for cellular inflammatory modulation study
Jae-Hee Shin(신재희),Min-Ho Hwang(황민호),Hyo-Geun Nam(남효근),Hyeong-Guk Son(손형국),Seung-Min Baek(백승민),Chang-Min Yoo(유창민),Jeong-Hun Park(박정훈),Jin-Su Jeong(정진수),Jae-Won Lee(이재원),Hyuk Choi(최혁) 대한전자공학회 2016 대한전자공학회 학술대회 Vol.2016 No.6
Electric stimulation (ES) is known to affect cell migration, proliferation, inflammation regulation, and physiological activities. However, there exist strong attenuation of electric field (EF) when conventional ES pass through tissue, and need of direct contact of target tissue and electrode has been magnified. In order to overcome these limitations, we have designed and fabricated precise ES device (MCS system), which can support with precise current density and adjustable frequency. Then we applied to degenerative disc disease (DDD) model in vitro. We showed that inflamed annulus fibrosus (AF) cells, which mimicked DDD model, express inflamatory cytokines such as interleukin (IL)-6, and –8 as contrasted with normal AF cells. But inflamed AF cells stimulated with ES and showed decrease in inflammatory cytokines. These results suggests that ES can be a therapeutic tool for inflammatory modulation and MCS is expected to be applied in many cell types and foster diverse applications of ES study fields.
Min Ho Hwang(황민호),Jae Hee Shin(신재희),Hyo Geun Nam(남효근),Hyeong Guk Son(손형국),Seung Min Baek(백승민),Chang Min Yoo(유창민),Jeong Hun Park(박정훈),Jin su Jeong(정진수),Jae won Lee(이재원),Hyuk Choi( 최혁) 대한전자공학회 2016 대한전자공학회 학술대회 Vol.2016 No.6
Intervertebral disc degeneration (IVD) is one of the important causes of low back pain and is associated with inflammation induced by interaction between macrophages and the human annulus fibrosus (AF) cells. Low level light therapy (LLLT) has been widely known to regulate inflammatory reaction. However, the effect of LLLT on macrophage-mediated inflammation in the AF cells has not been studied till date. The aim of this study is to mimic the inflammatory microenvironment and to investigate the anti-inflammatory effect of LLLT at a range of wavelengths (405, 532 and 650 nm) on the AF treated with macrophage-like THP-1 cells conditioned medium (MCM) containing proinflammatory cytokines and chemokines (interleukin-1beta, tumor necrosis factor-alpha, interleukin-6 and 8). We observed that AF cells exposed to MCM secrete significantly higher concentrations of IL-6, IL-8, IL-1b and TNF-a. LLLT markedly inhibited secretion of IL-6 at 405 nm in a time-dependent manner. Level of IL-8 was significantly decreased at all wavelengths in a time-dependent manner. We showed that MCM can induce the inflammatory microenvironment in AF cells and LLLT selectively suppressed IL-6 and 8 levels. The results indicate that LLLT is a potential method of IVD treatment and provide insights into further investigation of its antiinflammation effect on IVD.