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김진국,신향애,임채형,장현종,심대보 건국대학교 의과학연구소 2004 건국의과학학술지 Vol.13 No.-
Background and Objectives: Benign tumors of the nose and paranasal sinues are rare in comparison with malignant growths. Authors aimed to investigate the incidence and characteristics of benign sino-nasal tumors. Materials and Methods: From 1994 through 2004, 25 cases of benign sino-nasal tumors (17 men and 8 women) were diagnosed and cared at the Department of Otorhinolaryngology-Head and Neck Surgery, College of Medicine, Konkuk University. We reviewed medical records of patients to find out clinical features, radiologic findings, operative findings, therapeutic options, and outcomes. Postoperative observation was given for fifteen months on the average. Results: The most common symptom was nasal obstruction, followed by nasal mass, frequent nasal bleeding, headache, and rhinorrhea, and the mass mainly placed in the lateral nasal wall. There were 12 cases (48%) of inverted papilloma, 4 (16%) cases of squamous papilloma, 4 (16%) cases of hemangioma, 1 (4%) case of pleomorphic adenoma, 1 (4%) case of leiomyoma, 1 (4%) case of lipoma. All the tumors were surgically removed. For the treatment of inverted papilloma, medial maxillectomy had been performed before 1997(2 cases); however, most cases have been managed with endonasal endoscopic technique since 1997. Recurrence was observed in two patients with inverted papilloma and one patients with squamous papilloma. Conclusion: Inverted papilloma is the most common benign tumor in the nose and paranasal sinuses, followed by squamous papilloma and hemangioma. The optimal management of benign tumors is complete excision of tumor and endonasal endoscopic surgery is an effective treatment for an inverted papilloma.
FC 2-9 The diagnostic significance of the retraction sign in odontogenic cutaneous fistula
( Jin-hwa Son ),( Hyun-ju Jin ),( Hyang-suk You ),( Woo-haing Shim ),( Jeong-min Kim ),( Gun-wook Kim ),( Hoon-soo Kim ),( Hyun-chang Ko ),( Byung-soo Kim ),( Moon-bum Kim ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.2
Background: Odontogenic cutaneous fistula (OCF) could be a diagnostic challenge to dermatologists who are not familiar with this type of cutaneous fistula. However, the clinical manifestations of OCF can be non-specific and so we, dermatologists, need some meaningful sign for having clinical impression of OCF. Objectives: To assess the diagnostic significance of retraction sign in OCF. Methods: We just assessed retraction sign or not in OCF group (n=35) and control group (n=62). OCF group was collected based on OCF patient registrating data of our department for about 17 years (1999- 2016). Control group had clinical impression of OCF, but was diagnosed as other entities such as epidermal cyst, abscess, foreign body granuloma and etc. Results: Retraction sign was found in 88.6% (31/35) of OCF group and in 9.7% (6/62) of control group. And this difference had a statistical significance (P value <0.001). A control group with retraction were diagnosed as abscess, foreign body granuloma, furuncle and atrophic scar. There was morphologic difference of retraction sign between OCF group (mostly peripheral retraction around nodule or mass) and control group (mostly central retraction in nodule or mass). Conclusion: We suggest retraction sign could be clinically meaningful sign for OCF.
P177 Dermoscopic findings during the course of β -blocker treatment for infantile hemangioma
( Jin-hwa Son ),( Hyun-ju Jin ),( Hyang-suk You ),( Woo-haing Shim ),( Jeong-min Kim ),( Gun-wook Kim ),( Hoon-soo Kim ),( Byung-soo Kim ),( Moon-bum Kim ),( Hyun-chang Ko ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.2
<div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div> Background: Dermoscopy is a useful tool for examining morphology and structure of blood vessels in vascular skin lesions like infantile hemangioma (IH). However, dermoscopic findings are not fully elucidated in the course of β-blocker treatment for IH. Objectives: To investigate changes of dermoscopic findings during the course of β-blocker treatment for IH. Methods: Superficial or mixed-type IH patients treated with topical timolol solution or oral propranolol were enrolled in Pusan National University Hospitals (Busan and Yangsan) from November 2011 to January 2016. Clinical photograph and dermoscopic findings were recorded and assessed at the baseline, 1, 2, 3 and 6 months. Results: Total 115 patients (male: 38 and female: 77 / superficial type: 48 and mixed type: 67 / timolol: 77 and propranolol: 38) were included. Diffuse light erythema tended to be diminished but milky-red area increased gradually during the course of treatment. The patients treated with oral propranolol showed more prominent changes on each dermoscopic findings than those treated with topical timolol (p=0.023 and p=0.018, respectively). But, other findings like red-globular vessels, red-dot vessels, red-circulated vessels, red-linear vessels did not show significant changes. Conclusion: Dissolution of diffuse light erythema and increase of milky-red area were significant dermoscopic findings in accordance with clinical improvement after β -blocker therapy for IH.
Treatment with spironolactone in Becker`s nevus associated with ipsilateral breast hypoplasia
( Jin Hwa Son ),( Hyunju Jin ),( Hyang Suk You ),( Woo Haing Shim ),( Jeong Min Kim ),( Margaret Song ),( Hoon Soo Kim ),( Hyun Chang Ko ),( Byung Soo Kim ),( Moon Bum Kim ),( Gun Wook Kim ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.1
Becker nevus syndrome is the association of becker``s nevus with breast hypoplasia and other ipsilateral bone or muscle changes. It is considered to be a hormone-dependent disorder caused by a disturbance in the activity of the androgen receptor. The receptor appears to be increased in Becker``s nevus, which may influence to the development of associated lesions. Herein, we report a case of Becker nevus syndrome improved after the treatment with spironolactone. A 13-year-old girl presented with well-defined brownish patch over left breast for 8 years. In addition, she noticed hypoplasia of her ipsilateral breast (12 x 10 cm) since 10 years age. Histopathologic examinations revealed acanthosis, elongation of rete ridges in epidermis and hyperpigmentation of the basal epidermal layer. The diagnosis has been confirmed to Becker``s nevus associated with ipsilateral breast hypoplasia. The Laboratory test (CBC, electrolytes, and LH/FSH) done and showed normal range. Her hypoplastic breast was treated with spironolactone with 50mg single dosage twice daily. She experienced mild menstrual irregularity and it was improved within 1 month. The left breast had enlarged abruptly to 13 x 10.5 cm after the treatment of 19 weeks.
Unilateral nevoid hyperkeratosis of nipple and areola with gynecomastia induced by spironolactone
( Jin Hwa Son ),( Hyunju Jin ),( Hyang Suk You ),( Woo Haing Shim ),( Jeong Min Kim ),( Gun Wook Kim ),( Hoon Soo Kim ),( Byung Soo Kim ),( Moon Bum Kim ),( Hyun Chang Ko ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.1
Nevoid hyperkeratosis of the nipple and areola is a rare benign mammary condition characterized by asymptomatic hyperpigmented and verrucous hyperkeratosis of the nipples and areolae. Perez-Izquierto classification refers to 2 types as idiopathic and secondary type (local, systemic or drug related). A 68-year-old man presented with hyperkeratotic brownish plaque on the left areola for 2 months. He was given spironolactone for the management of heart failure for 3 years and he noticed insidious enlargement of both breasts since a year ago. Histopathologic finding from hyperkeratotic plaque showed hyperkeratosis, filiform acanthosis, hyperpigmentation of basal layer and mild dilatation of vessels in upper dermis. In according to clinical and histopathologic finding, he was diagnosed unilateral nevoid hyperkeratosis of the nipple and areola. Spironolactone, an anti-androgenic agent, can induce not only gynecomastia but also nevoid hyperkeratosis of the nipple and areola. However, nevoid hyperkeratosis of nipple and areola provoked by spironolactone usually presents bilaterally. In this case, gynecomastia showed asymmetry with dominant enlargement of left breast. Therefore, we speculate unilateral nevoid hyperkeratosis of the nipple and areola of this case may be induced by frequent rubbing due to asymmetric enlargement of left breast.
Five Cases of Phytophotodermatitis Caused by Fig Leaves and Relevant Literature Review
( Jin-hwa Son ),( Hyunju Jin ),( Hyang-suk You ),( Woo-haing Shim ),( Jeong-min Kim ),( Gun-wook Kim ),( Hoon-soo Kim ),( Hyun-chang Ko ),( Moon-bum Kim ),( Byung-soo Kim ) 대한피부과학회 2017 Annals of Dermatology Vol.29 No.1
Phytophotodermatitis is a condition caused by sequential exposure to photosensitizing substances present in plants followed by ultraviolet light. Several plants (e.g., limes, celery, fig, and wild parsnip) contain furocoumarin compounds (psoralens). It is important for dermatologists to be aware of phytophotodermatitis because it may be misdiagnosed as cellulitis, tinea, or allergic contact dermatitis. We present five patients with a sharply defined erythematous swollen patch with bullae on both feet. They described soaking their feet in a fig leaves decoction to treat their underlying dermatologic diseases. Within 24 hours, all patients had a burning sensation in their feet, and erythema and edema had developed on the feet dorsa with exception of the portion of the skin covered by the sandals. Histopathologic examinations revealed sub-epithelial blisters with intensive epidermal necrosis. Phytophotodermatitis was ultimately diagnosed and, after several days, the patients` skin lesions began to recover upon treatment with systemic and topical corticosteroids. Unfortunately, since there are no studies providing sufficient evidence on the benefits of fig leaves, they should be used with caution. (Ann Dermatol 29(1) 86∼90, 2017)
( Jin-hwa Son ),( Min-young Yang ),( Tae-wook Kim ),( Sung-min Park ),( Hyun-joo Lee ),( Hyunju Jin ),( Hyang-suk You ),( Woo-haing Shim ),( Gun-wook Kim ),( Hoon-soo Kim ),( Hyun-chang Ko ),( Moon-bu 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.2
Background: Various therapeutic modalities have been implemented for wart treatment. Recently, resistant warts treated using quadrivalent human papilloma virus (HPV) vaccine have been reported, although original articles on the efficacy of quadrivalent HPV vaccine on viral warts are rare. Objectives: To evaluate the efficacy of quadrivalent HPV vaccine in the treatment of multiple warts Methods: We retrospectively reviewed 30 patients with multiple warts who had been treated with quadrivalent HPV vaccine in Pusan National University Hospital from January 2014 to November 2016. All patients received 3 doses of quadrivalent HPV vaccine at baseline, 2 and 6 months. Patient demographics and clinical features were reviewed. Therapeutic response and adverse reactions following vaccination were assessed. Results: Regarding therapeutic response, 14 patients (46.67%) showed “Complete response”, 5 (16.67%) showed “Partial response”, and 11 (36.67%) showed “No response”. There were no statistically significant differences in sex, age, disease duration, and lesion number and location between the three groups divided by treatment response. No severe adverse events were noted. Conclusion: The advantage of quadrivalent HPV vaccine in the treatment of multiple warts is that it is more convenient and less painful. HPV vaccine might be a good alternative to conventional destructive methods for certain cases such as those including multiple warts, dangerous lesion locations, and uncooperative patients.
Shim, Jin-Hyung,Jeong, Jae-hyang,Won, Joo-Yun,Bae, Ji-Hyeon,Ahn, Geunseon,Jeon, Hojun,Yun, Won-Soo,Bae, Eun-Bin,Choi, Jae-Won,Lee, So-Hyoun,Jeong, Chang-Mo,Chung, Ho Yun,Huh, Jung-Bo Institute of Physics Publishing Ltd 2018 Biomedical Materials Vol.13 No.1
<P>The appropriate porosity and pore size of barrier membranes were associated with the transportation of biomolecules required for new bone formation and angiogenesis. In this study, we fabricated three-dimensional (3D)-printed resorbable polycaprolactone (PCL) membranes with different porosities (30%, 50%, and 70%) to evaluate the effective pore size for guided bone regeneration (GBR) membranes. To analyze mechanical properties and cytocompatibility, PCL membranes prepared using extrusion-based 3D printing technology were compared in dry and wet conditions and tested in vitro. The proliferation rates and pattern of fibroblasts and preosteoblasts on PCL membranes with different porosities were determined using a cell counting kit-8 assay and scanning electron microscopy. PCL membrane porosity did not affect cell proliferation, but osteogenic differentiation and mechanical properties were increased with lower porosity (30%) on day 14 (p < 0.001). Similar results were found in an in vivo calvarial defect model; new bone formation was significantly higher in PCL membranes with lower porosity (p < 0.001). These results indicate that 3D-printed PCL with 30% porosity (130 mu m pore size) is an excellent pore size for GBR membranes.</P>
Five cases of phytophotodermatitis to fig leaves and a review of literature
( Jin Hwa Son ),( Hyunju Jin ),( Hyang Suk You ),( Woo Haing Shim ),( Jeong Min Kim ),( Gun Wook Kim ),( Hoon Soo Kim ),( Hyun Chang Ko ),( Moon Bum Kim ),( Byung Soo Kim ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.1
Phytophotodermatitis is a dermatitis caused by sequential exposure to photosensitizing substance containing plants and then to ultraviolet light. Several plants (e.g., limes, celery, fig and wild parsnip) contain furocoumarin compounds (psoralens). It is important for a dermatologists to be aware of phytophotodermatitis because it may be misdiagnosed as cellulitis, tinea, and allergic contact dermatitis. We present 5 patients with sharply demarcated erythematous swollen patch with bullae on both feet. They reported that they soaked their feet in fig leaf decoction to treat their underlying dermatologic diseases. Within 24 hours, all had a burning sensation at both feet, and erythema and edema had developed on dorsum of feet except skin hidden below the sandal. Histopathologic examinations revealed subepithelial blister with intensive epidermal necrosis. Ultimately, a final diagnosis of a phytophotodermatitis was established and after several days, their skin lesions began to recover with treatment of systemic and topical corticosteroids. Unfortunately, as no study that provides sufficient evidence of the benefits of fig leaves, it should be used in caution.