[A Story by Hwang Sun-won] The Drizzle

Hwang Sun-won,Kim Chong-un(번역자) The Academy of Korean Studies 1968 Korea Journal Vol.8 No.1

머신 러닝을 위한 태양동기궤도위성의 추적데이터 생성

이병선(Byoung-Sun Lee),김원길(Won-Gil Kim),이준호(Junho Lee),황유라(Yoola Hwang) 한국항공우주학회 2018 한국항공우주학회 학술발표회 논문집 Vol.2018 No.4

황구침법(黃丘鍼法)을 이용한 고혈압 환자의 혈압강하 효과에 대한 증례보고

한창현 ( Chang Hyun Han ),황치원 ( Chi Won Hwang ),신미숙 ( Min Suk Shin ),신선화 ( Seon Hwa Shin ),최선미 ( Sun Mi Choi ) 대한경락경혈학회 2006 Korean Journal of Acupuncture Vol.23 No.3

Objectives: The aim of the study was to investigate the antihypertensive effect of Hwang-gu Acupuncture in hypertensive patients. Methods: We measured the blood pressure of the patients who were admitted in the Oriental Medical Clinic of Brother from 25th November 2005 to 27th March 2006. We included the patients only in case of the systolic blood pressure was over 140mmHg or diastolic blood pressure was over 90mmHg, Twenty two patients were treated by Hwang-gu Acupuncture. In order to evaluate the effect of the Hwang-gu Acupuncture, the blood pressure was measured before and after Acupuncture procedure total 4 times, 10times. Results: There were a significant decrease in the systolic blood pressure and significant decrease in the diastolic blood pressure by Hwang-gu Acupuncture 4 times. The effect of Hwang-gu Acupuncture by measurement time on blood pressure were follows: In a systolic blood pressure was gradually deceased significantly from 1st to 4th but diastolic blood pressure was significantly decreased after 2nd and 4th only. Conclusions: These results suggest that Hwang-gu Acupuncture is effective in decreasing the systolic and diastolic blood pressure.

In-depth analysis of the performance of hybrid desiccant cooling system incorporated with an electric heat pump

Hwang, Won-Baek,Choi, Sun,Lee, Dae-Young Pergamon Press 2017 Energy Vol.118 No.-

<P><B>Abstract</B></P> <P>Aiming for improvement of the cooling performance, the hybrid desiccant cooling system (<I>HDCS</I>) is investigated and compared with a reference desiccant cooling system (<I>RDCS</I>). By replacing a sensible wheel of the <I>RDCS</I> with a heat pump, the <I>HDCS</I> is expected to increase the energy efficiency as well as to improve the system compactness. The cooling cycle is simulated and its results are compared with those of the <I>RDCS</I>. The analysis showed that specific cooling power of the <I>HDCS</I> increases from that of <I>RDCS</I>, promising the miniaturization of the system. Also, COP of <I>HDCS</I> was found to overtake the COP of <I>RDCS</I> in a particular range of heat pump capacity. For analysis of total energy consumption, a new parameter, <SUB> R v </SUB> , the ratio of the primary energy factor of electrical energy to the primary energy factor of thermal energy was introduced. In the range of <SUB> R v </SUB> (=5–10) such as from the CHP plants, the optimal heat pump capacity was estimated when the heat pump occupies 30–40% of the total cooling output of the <I>HDCS</I>. With the optimal configuration, the total energy consumption of <I>HDCS</I> reduces by 20–30% and the cooling capacity of <I>HDCS</I> increases by 40–60%, compared to <I>RDCS</I>.</P> <P><B>Highlights</B></P> <P> <UL> <LI> A hybrid desiccant cooling system was proposed by replacing a sensible wheel with a heat pump. </LI> <LI> As the heat pump capacity increases, the total cooling output increases but the heat input for regeneration decreases. </LI> <LI> An optimal heat pump capacity with minimum total energy consumption is estimated. </LI> <LI> The total energy consumption decreases by 20–30% and cooling capacity increases by 40–60%. </LI> </UL> </P>

Effects of gintonin on the proliferation, migration, and tube formation of human umbilical-vein endothelial cells: involvement of lysophosphatidic-acid receptors and vascular-endothelial-growth-factor signaling

Hwang, Sung-Hee,Lee, Byung-Hwan,Choi, Sun-Hye,Kim, Hyeon-Joong,Won, Kyung Jong,Lee, Hwan Myung,Rhim, Hyewon,Kim, Hyoung-Chun,Nah, Seung-Yeol The Korean Society of Ginseng 2016 Journal of Ginseng Research Vol.40 No.4

Background: Ginseng extracts are known to have angiogenic effects. However, to date, only limited information is available on the molecular mechanism underlying the angiogenic effects and the main components of ginseng that exert these effects. Human umbilical-vein endothelial cells (HUVECs) are used as an in vitro model for screening therapeutic agents that promote angiogenesis and wound healing. We recently isolated gintonin, a novel ginseng-derived lysophosphatidic acid (LPA) receptor ligand, from ginseng. LPA plays a key role in angiogenesis and wound healing. Methods: In the present study, we investigated the in vitro effects of gintonin on proliferation, migration, and tube formation of HUVECs, which express endogenous LPA1/3 receptors. Results: Gintonin stimulated proliferation and migration of HUVECs. The LPA1/3 receptor antagonist, Ki16425, short interfering RNA against LPA1 or LPA3 receptor, and the Rho kinase inhibitor, Y-27632, significantly decreased the gintonin-induced proliferation, migration, and tube formation of HUVECs, which indicates the involvement of LPA receptors and Rho kinase activation. Further, gintonin increased the release of vascular endothelial growth factors from HUVECs. The cyclooxygenase-2 inhibitor NS-398, nuclear factor kappa B inhibitor BAY11-7085, and c-Jun N-terminal kinase inhibitor SP600125 blocked the gintonin-induced migration, which shows the involvement of cyclooxygenase-2, nuclear factor kappa B, and c-Jun N-terminal kinase signaling. Conclusion: The gintonin-mediated proliferation, migration, and vascular-endothelial-growth-factor release in HUVECs via LPA-receptor activation may be one of in vitro mechanisms underlying ginsenginduced angiogenic and wound-healing effects.

Hypoglycemic Effect of Polysaccharides Produced by Submerged Mycelial Culture of Laetiporus sulphureus on Streptozotocin-induced Diabetic Rats

Hwang, Hee-Sun,Yun, Jong-Won 한국생물공학회 2010 Biotechnology and Bioprocess Engineering Vol.15 No.1

The hypoglycemic effect of the crude extracellular polysaccharides (EPS) produced from submerged mycelial culture of an edible mushroomLaetiporus sulphureus var. miniatus in streptozotocin (STZ)-induced diabetic rat was investigated. Hypoglycemic effect of EPS was evaluated in STZ-induced diabetic rats, and its possible mechanism was suggested by the results of western blot analysis and immunohistochemical staining. The results revealed that orally administrated EPS, when given 48 h after STZ treatment exhibited an excellent hypoglycemic effect, lowering the average plasma glucose level in EPS-fed rats to 43.5% of STZ-treated rats. The plasma levels of total cholesterol and triglyceride were significantly increased upon STZ treatment and they were markedly reduced by oral administration of EPS to near-normal levels. The results of immunohistochemical staining of the pancreatic tissues showed that EPS treatment considerably increased the insulin antigenesity of diabetic islet ${\beta}$-cells, suggesting the possibility of ${\beta}$-cell proliferation or regeneration by EPS therapy. Moreover, immunoblotting study revealed that protein levels of iNOS was increased and SOD2, catalase, GPx were significantly increased after EPS treatments, suggesting alleviated oxidative stress mediated by STZ. Orally administrated EPS exhibited considerable hypoglycemic effect in STZ-induced diabetic rats and that these EPS may be useful for the management of diabetes mellitus.

Anti-obesity and Antidiabetic Effects of Deep Sea Water on ob/ob Mice

Hwang, Hee Sun,Kim, Hyun Ah,Lee, Sung Hak,Yun, Jong Won Springer-Verlag 2009 Marine biotechnology Vol.11 No.4

<P>Recently, deep sea water (DSW) has started to receive much attention for therapeutic intervention in some lifestyle diseases. In this study, the anti-obesity and antidiabetic effects of DSW in ob/ob mice were investigated. The animals were randomly divided into two groups with six animals: control group received tap water; the experimental group was treated with DSW of hardness 1000 for 84 days. The body weight gain after 84 days in DSW-fed group was decreased by 7% compared to the control group. The plasma glucose levels in the DSW-fed mice were substantially reduced by 35.4%, as compared to control mice. The results of oral glucose tolerance test revealed that DSW-fed groups significantly increased the glucose disposal after 84 days. DSW increased plasma protein levels of adiponectin and decreased plasma protein levels of resistin, RBP4, and fatty acid binding protein. Moreover, GLUT4 and AMP-activated protein kinase levels in skeletal muscle tissue were increased while peroxisome proliferator-activated receptor gamma and adiponectin were decreased in adipose tissue of DSW-fed mice. These results suggest that the antidiabetic and anti-obesity activities of DSW were mediated by modulating the expression of diabetes- and obesity-specific molecules. Taken together, these results provide a possibility that continuous intake of DSW can ameliorate obesity and diabetes.</P>

Caffeic acid phenethyl ester protects against photothrombotic cortical ischemic injury in mice

Sun Ae Hwang,Chi Dae Kim,Won Suk Lee 대한생리학회-대한약리학회 2018 The Korean Journal of Physiology & Pharmacology Vol.13 No.4

In this study, we aimed to investigate the neuroprotective effects of caffeic acid phenethyl ester (CAPE), an active component of propolis purified from honeybee hives, on photothrombotic cortical ischemic injury in mice. Permanent focal ischemia was achieved in the medial frontal and somatosensory cortices of anesthetized male C57BL/6 mice by irradiation of the skull with cold light laser in combination with systemic administration of rose bengal. The animals were treated with CAPE (0.5-5 mg/kg, i.p.) twice 1 and 6 h after ischemic insult. CAPE significantly reduced the infarct size as well as the expression of tumor necrosis factor-α, hypoxia-inducible factor-1α, monocyte chemoattractant protein-1, interleukin-1α, and in-doleamine 2,3-dioxygenase in the cerebral cortex ipsilateral to the photothrombosis. Moreover, it induced an increase in heme oxygenase-1 immunoreactivity and interleukin-10 expression. These results suggest that CAPE exerts a remarkable neuroprotective effect on ischemic brain injury via its anti-inflammatory properties, thereby providing a benefit to the therapy of cerebral infarction.

Effects of Methimazole on the Onset of Type 2 Diabetes in Leptin Receptor-Deficient Rats

HWANG, In Koo,KIM, Il Yong,KIM, Yo Na,YI, Sun Shin,LEE, Yu Hee,JU, Eun Jeong,LEE, In Se,PARK, In-Sun,WON, Moo-Ho,YOON, Yeo Sung,SEONG, Je Kyung Japanese Society of Veterinary Science 2009 The Journal of veterinary medical science Vol.71 No.3

<P>We investigated the effects of methimazole, an anti-thyroid drug, on the onset of type 2 diabetes in Zucker diabetic fatty (ZDF) rats. For this, 0.03% methimazole was administered to 7-week-old, pre-diabetic ZDF rats in drinking water for 5 weeks and the animals were sacrificed at 12 weeks of age. Methimazole treatment to ZDF rats significantly reduced blood glucose levels, food intake, body weight, and serum T3 levels. Hepatocytes in ZDF-methi rats were more densely stained with eosin than those in ZDF rats because of low fat accumulation in ZDF-methi hepatocytes. The pancreatic islet in ZDF-methi rats was normal compared to that in ZDF rats. Glucagon, not insulin, immunoreactivity in ZDF-methi rats was significantly higher than that in ZDF-methi rats. These suggest that methimazole treatment may delay the onset of type 2 diabetes in leptin receptor-deficient rats and also suggests that thyroid hormones may be necessary for the onset of diabetes.</P>

Immunomodulatory activity of <i>Lactobacillus</i> strains isolated from fermented vegetables and infant stool

Won, Tae Joon,Kim, Bongjoon,Oh, Eun Seul,Bang, Joon Seok,Lee, Yoon Jeong,Yoo, Jong-Sun,Yu, Hyunmin,Yoon, Joowon,Hyung, Kyeong Eun,Park, So-Young,Hwang, Kwang Woo Canadian Science Publishing 2011 Canadian journal of physiology and pharmacology Vol.89 No.6

<P> Four Lactobacillus strains - Lactobacillus plantarum CJLP133, L. plantarum CJLP243, L. plantarum CJNR26, and Lactobacillus gasseri CJMF3 - were isolated from Korean fermented food or healthy infant feces, and their capacity to modulate cellular and humoral immune responses was studied. Feeding of the tested lactobacilli for 8 weeks did not alter the weight of and cell numbers in the spleen of mice. However, CJLP133 and CJLP243 strains increased the T lymphocyte population in the spleen of mice, while CJNR26 and CJMF3 increased the B lymphocyte population. In splenocytes treated with concanavalin A, ingestion of CJLP133 and CJLP243 promoted T lymphocyte proliferation and secretion of T cell cytokines, whereas feeding of the CJNR26 and CJMF3 strains enhanced B lymphocyte proliferation in splenocytes treated with lipopolysaccharide and plaque formation. These results suggest that CJLP133 and CJLP243 have immunostimulating activity through the enhancement of T cell activation, while CJNR26 and CJMF3 exhibit immunopotentiation through the increment of B cell activation. </P>