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Weiwei Ma,Bingjie Ding,Huanling Yu,Linhong Yuan,Yuandi Xi,Rong Xiao 한국식품영양과학회 2015 Journal of medicinal food Vol.18 No.3
Genistein (GEN), a major soybean isoflavone (SIF), might possess neuroprotective properties through its antiinflammatory activity. We hypothesized that GEN could prevent the inflammatory damage detected in C6 cells induced by β-amyloid peptides 25-35 (Aβ25-35). Accordingly, we evaluated the inflammatory damage induced by Aβ25-35 and the protective effect of GEN against Aβ25-35 in C6 cells. In our study, the C6 glial cells (rats glioma cell lines) were preincubated with or without GEN for 2 h following incubation with Aβ25-35 for another 24 h. Then, methylthiazolyl tetrazolium (MTT) assay was used to assess the cell viability. Immunofluorescence staining was used to identify the C6 cells. Inflammatory factors tumor necrosis factor (TNF)-α and interleukin (IL)-1β were analyzed by using enzyme-linked immunosorbent assay (ELISA). Western blot analysis and reverse transcription-polymerase chain reaction analysis were performed to assess the expression of Toll-like receptors 4 (TLR4), inhibitor of kappaB-alpha (IκB-α). The current results showed that GEN could alleviate Aβ25-35-induced cell apoptosis and prevent Aβ25-35-induced TNF-α and IL-1β release from C6 cells. In addition, GEN prevented Aβ25-35-induced upregulation of the gene and protein expression of TLR4, and GEN significantly upregulated the expression of IκB-α in C6 cells damaged by Aβ25-35. These results suggest that GEN can alleviate the inflammatory stress caused by Aβ25-35 treatment, which might be associated with the neuroprotective effect of GEN regulating the TLR4/NFκB signaling pathway.
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Permeability Anisotropy of Columnar Jointed Rock Masses
Lifang Zou,Weiya Xu,Guotao Meng,Yu Ning,Huanling Wang 대한토목학회 2018 KSCE JOURNAL OF CIVIL ENGINEERING Vol.22 No.10
This paper investigated the anisotropic permeability of columnar jointed rock masses at Baihetan hydropower station in Southwest China. Discrete element analysis is conducted to evaluate the hydraulic Representative Elemental Volume (REV) size of jointed rock masses. It is found to be 5m×5m and it is seven times of the column length. Research shows that permeability tensor of the jointed rocks exists. The maximum principle permeability is 3.47 × 10−14 m2 and the minimum principle permeability is 1.39 × 10−14 m2. The direction of maximum principle permeability is 72 degrees anticlockwise from the positive x- axis direction, which is along the same direction of the column length. A continuum hydro-mechanical coupling analysis is carried out on water infill of a tailrace tunnel in columnar basalt. An equivalent anisotropic mechanical model is applied in the numerical simulation. Anisotropic deformation and anisotropic permeability characteristics are investigated under the condition that the angle between maximum principle stress axis and maximum principle permeability axis is 72 degrees. Results show that anisotropic seepage field has an effort on anisotropic deformation field.
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