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      • KCI등재

        A Compact Dual-Band MIMO Antenna for Sub-6 GHz 5G Terminals

        Dong Guiting,Huang Jianlin,Lin Simin,Chen Zhizhou,Liu Gui 한국전자파학회 2022 Journal of Electromagnetic Engineering and Science Vol.22 No.5

        In this paper, a dual-band multiple-input-multiple-output (MIMO) antenna is proposed for fifth-generation (5G) wireless communication terminals. The measured -10 dB impedance bandwidths of 380 MHz (3.34–3.72 GHz) and 560 MHz (4.57–5.13 GHz) can cover the 3.4–3.6 GHz and 4.8–5 GHz 5G bands. The single antenna element of this proposed MIMO is composed of an F-shaped feed strip and an inverted L-shaped radiation strip. A defected ground structure is employed to obtain a good isolation performance, whereby the measured isolation between the antenna elements is observed to be larger than 23 dB. The measured total radiation efficiencies at 3.5 GHz and 4.9 GHz are 76.65% and 71.93%, respectively. Besides, the calculated envelope correlation coefficients (ECC) are less than 0.00125 and 0.01164 at the low-frequency and high-frequency bands, respectively. Furthermore, the specific absorption ratio (SAR) analysis of the antenna verifies that it qualifies for 5G terminals.

      • SCIESCOPUSKCI등재

        An engineered PD-1-based and MMP-2/9-oriented fusion protein exerts potent antitumor effects against melanoma

        ( Mulan Wei ),( Xujie Liu ),( Chunyu Cao ),( Jianlin Yang ),( Yafeng Lv ),( Jiaojiao Huang ),( Yanlin Wang ),( Ye Qin ) 생화학분자생물학회 2018 BMB Reports Vol.51 No.11

        Recent studies showed that the PD-1/PD-L1 checkpoint blockade is a dramatic therapy for melanoma by enhancing antitumor immune activity. Currently, major strategies for the PD-1/PD-L1 blockade have mainly focused on the use of antibodies and compounds. Seeking an alternative approach, others employ endogenous proteins as blocking agents. The extracellular domain of PD-1 (ePD1) includes the binding site with PD-L1. Accordingly, we constructed a PD-1-based recombinantly tailored fusion protein (dFv-ePD1) that consists of bivalent variable fragments (dFv) of an MMP-2/9-targeted antibody and ePD1. The melanoma-binding intensity and antitumor activity were also investigated. We found the intense and selective binding capability of the protein dFv-ePD1 to human melanoma specimens was confirmed by a tissue microarray. In addition, dFv-ePD1 significantly suppressed the migration and invasion of mouse melanoma B16-F1 cells, and displayed cytotoxicity to cancer cells in vitro. Notably, dFv-ePD1 significantly inhibited the growth of mouse melanoma B16-F1 tumor cells in mice and in vivo fluorescence imaging showed that dFv-ePD was gradually accumulated into the B16-F1 tumor. Also the B16-F1 tumor fluorescence intensity at the tumor site was stronger than that of dFv. This study indicates that the recombinant protein dFv-ePD1 has an intensive melanoma-binding capability and exerts potent therapeutic efficacy against melanoma. The novel format of the PD-L1-blocked agent may play an active role in antitumor immunotherapy. [BMB Reports 2018; 51(11): 572-577]

      • KCI등재

        Preparation of silver Nano-Crystal patterns in oxide glasses under electric field accompanied by heat treatment

        Jian Lin,Wen-Hai Huang,Shu-Hua Lei,Chang-Cheng Liu,Qi Bian,Li-Na Ma,Dong-Wei Li 한양대학교 세라믹연구소 2008 Journal of Ceramic Processing Research Vol.9 No.4

        Nano-crystals embedded in glass always have interesting quantum effects, while nano-crystal patterns may have wide potential applications in preparing PIC, OEIC and other types of electronic and optoelectronic devices. A direct current electric field, accompanied by heat treatment, was applied on tellurite or silicate glass sheets. The silver ions in a diffused film were introduced into the glass matrix under a high-voltage electric field, instead of supplied during glass melting. The direct diffusion of metal ions, the nucleation and crystallization of nano-crystals in the glass were well controlled by the electric field accompanied by heat treatment. It was found that silver nano-crystal patterns can be transfer printed into tellurite and silicate glass sheets with both patterned diffusion and patterned crystallization. Nano-crystals embedded in glass always have interesting quantum effects, while nano-crystal patterns may have wide potential applications in preparing PIC, OEIC and other types of electronic and optoelectronic devices. A direct current electric field, accompanied by heat treatment, was applied on tellurite or silicate glass sheets. The silver ions in a diffused film were introduced into the glass matrix under a high-voltage electric field, instead of supplied during glass melting. The direct diffusion of metal ions, the nucleation and crystallization of nano-crystals in the glass were well controlled by the electric field accompanied by heat treatment. It was found that silver nano-crystal patterns can be transfer printed into tellurite and silicate glass sheets with both patterned diffusion and patterned crystallization.

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