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PMN-PT Single Crystal for Endoscopic Ultrasound 2D Array Application
Yuhang Zhu,Huageng Liang,Benpeng Zhu,Dan Zhou,Xiaofei Yang 대한금속·재료학회 2017 ELECTRONIC MATERIALS LETTERS Vol.13 No.2
Based on lead magnesium niobate-lead titanate single crystal, a 24 × 24row-column addressing endoscopic two-dimensional array has beensuccessfully fabricated using novel flanged electrodes and “semi-kerf”technologies. Each row/column array element was measured to have anelectromechanical coupling coefficient of 0.81, a center frequency of5MHz, and a fractional bandwidth of approximately 88% at −6 dB. Ofparticular significance was that the lead magnesium niobate-lead titanateelement exhibits much higher sensitivity compared with lead zirconatetitanate-based 2D arrays with similar operational frequency and elementarea. According to the Field II simulated results, although the obtainedbeamwidth at −6 dB was a little inferior to that of the fully sampled 24 × 24two-dimensional array, it is believed that the beamwidth can be improved byappropriately increasing the element number. These results demonstratedthat the lead magnesium niobate-lead titanate single-crystal 2D array is apromising candidate for real-time three-dimensional endoscopic ultrasoundimaging.
Lin Wang,Jingjing Miao,Huageng Huang,Boyu Chen,Xiao Xiao,Manyi Zhu,Yingshan Liang,Weiwei Xiao,Shaomin Huang,Yinglin Peng,Xiaowu Deng,Xing Lv,Weixiong Xia,Yanqun Xiang,Xiang Guo,Fei Han,Chong Zhao 대한암학회 2022 Cancer Research and Treatment Vol.54 No.1
Purpose This study was aimed to investigate long-term survivals and toxicities of early-stage nasopharyngeal carcinoma (NPC) in endemic area, evaluating the role of chemotherapy in stage II patients. Materials and Methods Totally 187 patients with newly diagnosed NPC and restaged American Joint Committee on Cancer/ International Union Against Cancer 8th T1-2N0-1M0 were retrospectively recruited. All received intensity-modulated radiotherapy (IMRT)±chemotherapy (CT) from 2001 to 2010. Results With 15.7-year median follow-up, 10-year locoregional recurrence-free survival, distant metastasis-free survival (DMFS), disease-specific survival (DSS), and overall survival (OS) were 93.3%, 93.5%, 92.9% and 88.2%, respectively. Multivariable analyses showed cervical lymph nodes positive and pre-treatment prognostic nutritional index ≥ 52.0 could independently predict DMFS (p=0.036 and p=0.011), DSS (p=0.014 and p=0.026), and OS (p=0.002 and p < 0.001); Charlson comorbidity index < 3 points could predict DSS (p=0.011); age > 45 years (p=0.002) and pre-treatment lactate dehydrogenase ≥ 240 U/L (p < 0.001) predicted OS. No grade 4 late toxicity happened; grade 3 late toxicities included subcutaneous fibrosis (4.3%), deafness or otitis (4.8%), skin dystrophy (2.1%), and xerostomia (1.1%). No differences on survivals were shown between IMRT+CT vs. IMRT alone in stage II patients, even in T2N1M0 (p > 0.05). Unsurprising, patients in IMRT+CT had more acute gastrointestinal reaction, myelosuppression, mucositis, late ear toxicity, and cranial nerve injury (all p < 0.05) than IMRT alone group. Conclusion Superior tumor control and satisfying long-term outcomes could be achieved with IMRT in early-stage NPC with mild late toxicities. As CT would bring more toxicities, it should be carefully performed to stage II patients.