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Label-free Microarray-based Binding Affinity Constant Measurement with Modified Fluidic Arrangement
junwei Hu,Ru Chen,Chenggang Zhu,Bilin Ge,Xiangdong Zhu,Lan Mi,Jiong Ma,Caiqin Han,Hao Chen,Yiyan Fei 한국바이오칩학회 2018 BioChip Journal Vol.12 No.1
The oblique-incidence reflectivity difference (OI-RD) scanning microscopy has the capability of simultaneously measuring binding curves of a protein probe with tens of thousands molecular targets in a microarray and yielding reaction rate constants. However, the quality of reaction rate constants is influenced by the fluidic system. To improve the quality of reaction rate constant measurement over the entire microarray, we demonstrate a fluidic chamber that allows the fluid to flow from the bottom to the top uniformly across the microarray and thus provides more uniform and accurate measurements of reaction rate constants with simplified fluidic design.
Du Junwei,Jing Guanghui,Hu Qiang 한국CDE학회 2022 Journal of computational design and engineering Vol.9 No.4
In the chemical safety evaluation system, the optimization of indicator weights needs to take both experts’ evaluations and the feedback on accident influences into account. Thus, this paper proposes a comprehensive weighting method based on the association bipartite graph (ABG). The accident influences and correlation intensity between the accident and the evaluation indicators are calculated on the ABG. A random walk algorithm, which integrates the objective influences of the accidents and the subjective evaluations of experts, is designed to realize the weight optimization. Experiments prove the effectiveness of the proposed method from the perspectives of weight ranking and fitting degree.
Jianghuai Hu,Gang Yang,Junwei Zhang,Yun Zou,Ke Zeng 한국고분자학회 2014 Macromolecular Research Vol.22 No.10
Approaches to promote the post-cure reaction of polyimide with pendant phthalonitrile unit (CN-PI) werefirst realized by introducing of hydroxyl groups via chemical copolymerization or physical blending. The post-curereaction of the CN-PI was performed at 250 or 300 oC, and monitored by various techniques, such as infrared spectroscopy(IR), differential scanning calorimetry (DSC), wide-angle X-ray diffraction (WAXD), scanning electronmicroscopy (SEM), and thermogravimetric analysis (TGA). A significant result was found in that the trend of theincreasing glass transition temperature Tg with nitrile conversion followed DiBenedetto’s equation. This provided achance to deeply discuss the relationship between molecular structure, segmental mobility, and cure behavior of CNPI. Chemical structure changes and morphology evolution of the polymer during post-cure process were investigatedby IR, WAXD, and SEM. The thermal and mechanical properties of polymer films showed it to be a thermallystable and strong material.
Piezo channels in the urinary system
Li Xu,Hu Junwei,Zhao Xuedan,Li Juanjuan,Chen Yuelai 생화학분자생물학회 2022 Experimental and molecular medicine Vol.54 No.-
The Piezo channel family, including Piezo1 and Piezo2, includes essential mechanosensitive transduction molecules in mammals. Functioning in the conversion of mechanical signals to biological signals to regulate a plethora of physiological processes, Piezo channels, which have a unique homotrimeric three-blade propeller-shaped structure, utilize a cap-motion and plug-and-latch mechanism to gate their ion-conducting pathways. Piezo channels have a wide range of biological roles in various human systems, both in vitro and in vivo. Currently, there is a lack of comprehensive understanding of their antagonists and agonists, and therefore further investigation is needed. Remarkably, increasingly compelling evidence demonstrates that Piezo channel function in the urinary system is important. This review article systematically summarizes the existing evidence of the importance of Piezo channels, including protein structure, mechanogating mechanisms, and pharmacological characteristics, with a particular focus on their physiological and pathophysiological roles in the urinary system. Collectively, this review aims to provide a direction for future clinical applications in urinary system diseases.
A real-time sorting algorithm for in-beam PET of heavy-ion cancer therapy device
Ke, Lingyun,Yan, Junwei,Chen, Jinda,Wang, Changxin,Zhang, Xiuling,Du, Chengming,Hu, Minchi,Yang, Zuoqiao,Xu, Jiapeng,Qian, Yi,She, Qianshun,Yang, Haibo,Zhao, Hongyun,Pu, Tianlei,Pei, Changxu,Su, Hong Korean Nuclear Society 2021 Nuclear Engineering and Technology Vol.53 No.10
A real-time digital time-stamp sorting algorithm used in the In-Beam positron emission tomography (In-Beam PET) is presented. The algorithm is operated in the field programmable gate array (FPGA) and a small amount of registers, MUX and memory cells are used. It is developed for sorting the data of annihilation event from front-end circuits, so as to identify the coincidence events efficiently in a large amount of data. In the In-Beam PET, each annihilation event is detected by the detector array and digitized by the analog to digital converter (ADC) in Data Acquisition Unit (DAQU), with a resolution of 14 bits and sampling rate of 50 MS/s. Test and preliminary operation have been implemented, it can perform a sorting operation under the event count rate up to 1 MHz per channel, and support four channels in total, count rate up to 4 MHz. The performance of this algorithm has been verified by pulse generator and <sup>22</sup>Na radiation source, which can sort the events with chaotic order into chronological order completely. The application of this algorithm provides not only an efficient solution for selection of coincidence events, but also a design of electronic circuit with a small-scale structure.
Measurement of TOF of fast neutrons with <sup>238</sup>U target
Li, Meng,Guan, Yuanfan,Lu, Chengui,Zhang, Junwei,Yuan, Xiaohua,Duan, Limin,Yang, Herun,Hu, Rongjiang,He, Zhiyong,Wei, Xianglun,Ma, Peng,Gan, Zaiguo,Yang, Chunli,Zhang, Hongbin,Chen, Liang,Qiu, Tianli Korean Nuclear Society 2021 Nuclear Engineering and Technology Vol.53 No.6
We developed a Dual-PPACs detector for fast neutron measurements that consists of two sets of PPAC: conventional PPAC and fission PPAC. A<sup>238</sup>U(U<sub>3</sub>O<sub>8</sub>) coating is placed in the fission PPAC's anode, which is used as the neutrons conversion layer. An experiment was performed to measure neutron time-of-flight (TOF) in which <sup>252</sup>Cf spontaneous fission source was used. An excellent time resolution of 164ps has been observed at 6 mbar in isobutene gas. With the excellent time resolution of Dual-PPACs detector, exact neutron energy can be extracted from the timing measurement. The experimental detection efficiency was 1.9 × 10<sup>-7</sup>, consistent with the efficiency of 2.5 × 10<sup>-7</sup> given by a Geant4 simulation. Ultimately, the results show that the Dual-PPACs detector is a suitable candidate for measuring fast neutrons in the future CiADS system.
Suppression of stray electrons in the negative ion accelerator of CRAFT NNBI test facility
Yang Yuwen,Wei Jianglong,Xie Junwei,Gu Yuming,Xie Yahong,Hu Chundong 한국원자력학회 2023 Nuclear Engineering and Technology Vol.55 No.3
Comprehensive Research Facility for Fusion Technology (CRAFT) is an integration of different demonstrating or testing facilities, which aim to develop the critical technology or composition system towards the fusion reactor. Due to the importance and challenge of the negative ion based neutral beam injection (NNBI), a NNBI test facility is included in the framework of CRAFT. The initial object of CRAFT NNBI test facility is to obtain a H0 beam power of 2 MW at the energy of 200e400 keV for the pulse duration of 100 s. Inside the negative ion accelerator of NNBI system, the interactions of the negative ions with the background gas and electrodes can generate abundant stray electrons. The stray electrons can be further accelerated and dumped on the electrodes or eject from the accelerator. The stray electrons, including the ejecting electrons, cause the unwanted particle and heat flux onto the electrodes and the inner components of beamline (especially the temperature sensitive cryopump). The suppression of the stray electrons from the CRAFT accelerator is carried out via a series of design and simulation works. The paper focuses the influence of different magnetic field configurations on the stray electrons and the character of the ejecting electrons.
Development of Parallel Plate Avalanche Counter for heavy ion collision in radioactive ion beam
Wei, Xianglun,Guan, Fenhai,Yang, Herun,Wang, Yijie,Zhang, Junwei,Ma, Peng,Diao, Xinyue,Lu, Chengui,Li, Meng,Guan, Yuanfan,Duan, Limin,Hu, Rongjiang,Zhang, Xiuling,Xiao, Zhigang Korean Nuclear Society 2020 Nuclear Engineering and Technology Vol.52 No.3
We have developed a position-sensitive Parallel Plate Avalanche Counter (PPAC) to detect the fission fragments and reconstruct the fission reaction plane in the experiment of studying nuclear equation of state (nEOS) by means of heavy ion collision (HIC). This experiment put forward high requirements for the performances of PPAC, such as the time resolution, efficiency and position resolution. According to these requirements we designed the PPAC with an active area of 240 mm × 280 mm working at low gas pressure. The results show that time resolution could be less than 300 ps. Position resolution is consistent with the theoretical calculation about 1.35 mm. Detection efficiency could be approaching 100% gradually with the voltage increasing in different gas pressures. The performances of PPAC have also been verified in beam experiment. Each set of anode wires can be accurately separated in the position spectrum. In the beam experiment, we also got the back-to-back correlation of fission fragments which is one of the direct signals characterizing binary decay.