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Yu Zhang,Huating Dou,Hong-Jun Li,Zhi-Fei He,Houjiu Wu 한국식품과학회 2014 Food Science and Biotechnology Vol.23 No.1
The cellular effects of nobiletin on humanpancreatic cancer cells (PANC-1) and the mechanisms bywhich nobiletin inhibits the proliferation of these cells wereinvestigated. A MTT assay and flow cytometry were usedto examine cell proliferation and apoptosis, respectively. AWestern blot assay was used to examine expression levelsof the apoptotic proteins bax, bcl-2, and p53. NOB inducedapoptosis in these cells via up-regulation of the proapoptoticprotein bax and down-regulation of the antiapoptoticproteins bcl-2 and p53. The normal cell cycle ofPANC-1 cells was arrested by NOB with a significantincrease in the proportion of G0/G1 phase cells (p<0.05)and a significant decrease in the proportion of S phase cells(p<0.05). NOB can inhibit the proliferation of humanpancreatic carcinoma cells by inducing apoptosis andarresting the cell cycle progression.
Yu Zhang,Hong-Jun Li,Huating Dou,Zhi-Fei He,Houjiu Wu,Zhigao Sun,Hua Wang,Xuegen Huang,Yaqin Ma 한국식품과학회 2013 Food Science and Biotechnology Vol.22 No.suppl1
Nobiletin (NOB) is a well-known polymethoxylated flavone that has only been found in citrus. The objective of this study is to obtain the optimal conditions for extracting nobiletin from sweet orange residues by microwave-assisted extraction (MAE) using response surface method. By using the Box-Behnken experimental design and SAS software 3 independent variables including solid/solvent ratio, microwave power, and treatment time were examined for the response variable nobiletin extraction yield. The regression Eq. 7 statistically significant (p<0.001) and R2 was 0.9189. Based on our regression result and considering the feasibility of experiment conduction, we chose the following independent variable values as the optimized conditions for the extraction of NOB: 1:21.91(g/mL) for the solid/solvent ratio, 14.16 min for the treatment time, and 693.72 W for the microwave power. Under these conditions, the nobiletin yield of 267.8 μg/g of byproduct was achieved.