Incorporation of Media in the Activities of Scientific Library of Higher Education Institution

Horban, Yurii,Berezhna, Oksana,Bohush, Iryna,Doroshenko, Yevhenii,Kovbel, Viktoriia International Journal of Computer ScienceNetwork S 2022 International journal of computer science and netw Vol.22 No.4

Students can successfully connect with one another thanks to the introduction of Web 2.0 and the tools and technology linked with it. The fact that rising digital tools are systematically influencing the education system is not a secret. The purpose of the research article efficiently evaluates the influence of incorporation of media in the activities of the scientific library of the higher education institution. The research Methodology is the Concepts, techniques, and procedures to effectively inculcate primary and secondary data to conduct the research effortlessly. It's worth noting that in this case, quantitative primary research was provided in the form of a survey. The researchers have proposed a survey in order to successfully instil a comprehensive view on the "incorporation of media in the operations of the scientific library of higher education institutions." As a result, fifty-one higher education institution principals were asked to attend this session. This is necessary to understand that they are both well-educated and cognizant of the impact of technology innovation on schooling. As a result, the researchers were able to gain a comprehensive view of this situation thanks to this survey. The results effectively showed that most of the participants believe that social media plays a vital role in shaping up higher education and at the same time they believe that the libraries of famous educational institutions must adapt as per the new educational trend so that teachers and students both can tap into its benefit.The practical significance of the result is manoeuvred by the efficient survey analysis and at the same time, peer-reviewed journals have been employed to put forward authentic information. Therefore, efficient insight regarding this topic has been gathered by the researchers.

Virtual and Augmented Reality Technologies in the Organization of Modern Library Media Space

Horban, Yurii,Gaisynuik, Nataliya,Dolbenko, Tetiana,Karakoz, Olena,Kobyzhcha, Nataliia,Kulish, Yuliia International Journal of Computer ScienceNetwork S 2022 International journal of computer science and netw Vol.22 No.5

Virtual and augmented reality technologies provide access to learning materials and improve the organization of a modern library's media space. This article aims to identify the significance and role of virtual and augmented reality technologies in the modern library's media space organization. Methodology. The research uses a university library case study methodology to empirically investigate virtual and augmented reality technologies. Results. Virtual and augmented reality technologies provide research and improve learning outcomes by engaging students and learners with significant interest in such technologies. Libraries offer users the opportunity to create their VR content through available software. Students can test their VR content in the libraries' labs. Libraries support access to a variety of virtual and augmented reality content. The content is accessed using "virtual reality headsets" for viewing and workstations with "authoring software and loanable 360 cameras" for creating. The library lab is a space to support students' digital creativity and research through virtual and augmented reality. There are 3D Design Labs within the libraries as a medium to large group design learning spaces with virtual reality technology. Libraries form a media space where users can create videos, podcasts, portfolios, edit media, and book tours, and students and researchers can explore different scientific knowledge. In this way, technology ensures that risks in learning are minimized as opposed to hands-on seminars and classes.

Human Capital as a Development Factor for Cultural and Creative Industries

Horban, Yurii,Dolbenko, Tetiana,Yaroshenko, Tetiana,Sokol, Oleksandr,Miatenko, Nataliia International Journal of Computer ScienceNetwork S 2021 International journal of computer science and netw Vol.21 No.12

Human capital is the defining value of the national economy under market conditions. The manifestation of human capital is realized as an intellectual and creative capital, theoretically grounded and proven. The realization of intellectual capital is realized through the research creativity of scientists and researchers, and creative capital is manifested through artists and thinkers. Accordingly, creativity in market conditions forms a separate source of income and is an essential article in the formation of the GDP of the national economy. This research aims to analyze human capital from the perspective of cultural and creative industries. Research methods: systematization; comparative analysis of individual indicators of advanced countries of the world on the training system; statistical, taking into account macroeconomic indicators to assess the level of national creativity potential; system and logical analysis; method of information synthesis. Research results. The structural and quantitative composition of the factors of intellectual and creative capital formation has been systematized. The article proves that the unique properties of human capital, knowledge, creativity, experience and professional skills are the push factors of creativity development of the national economy and provide the priority development of creative and cultural industry that allows generating the added value on the national scale. The functions of creativity in the sphere of cultural industries are highlighted. It is noted that education and creativity of both intellectual and creative capital are the forming basis. The research of the world's advanced countries on the creativity index has pointed out the Netherlands as the leading country in the quantitative measurement of creativity. The economic development factors of the Netherlands were analyzed from the position of economic creativity, which allowed the formation of a two-factor model providing priority development of creativity in the cultural and creative industries.

Human Capital as a Development Factor for Cultural and Creative Industries

Horban, Yurii,Dolbenko, Tetiana,Yaroshenko, Tetiana,Sokol, Oleksandr,Miatenko, Nataliia International Journal of Computer ScienceNetwork S 2021 International journal of computer science and netw Vol.21 No.spc12

Human capital is the defining value of the national economy under market conditions. The manifestation of human capital is realized as an intellectual and creative capital, theoretically grounded and proven. The realization of intellectual capital is realized through the research creativity of scientists and researchers, and creative capital is manifested through artists and thinkers. Accordingly, creativity in market conditions forms a separate source of income and is an essential article in the formation of the GDP of the national economy. This research aims to analyze human capital from the perspective of cultural and creative industries. Research methods: systematization; comparative analysis of individual indicators of advanced countries of the world on the training system; statistical, taking into account macroeconomic indicators to assess the level of national creativity potential; system and logical analysis; method of information synthesis. Research results. The structural and quantitative composition of the factors of intellectual and creative capital formation has been systematized. The article proves that the unique properties of human capital, knowledge, creativity, experience and professional skills are the push factors of creativity development of the national economy and provide the priority development of creative and cultural industry that allows generating the added value on the national scale. The functions of creativity in the sphere of cultural industries are highlighted. It is noted that education and creativity of both intellectual and creative capital are the forming basis. The research of the world's advanced countries on the creativity index has pointed out the Netherlands as the leading country in the quantitative measurement of creativity. The economic development factors of the Netherlands were analyzed from the position of economic creativity, which allowed the formation of a two-factor model providing priority development of creativity in the cultural and creative industries.

Training of Future Specialists in Modern Conditions: Cultural Aspects

Horban, Yurii,Koshelieva, Oksana,Bigus, Olga,Chepalov, Oleksandr,Bazela, Dmytro International Journal of Computer ScienceNetwork S 2022 International journal of computer science and netw Vol.22 No.7

An increasing number of students from different cultures study in higher primary schools. This trend is due to: 1) the government's discourse on increasing the level of participation of foreign students in national educational programs and the need for internationalization; 2) the need of employers for professionals who are trained to work in a multicultural environment to meet the needs of different markets and customers. Methodology. This study is based on the results of the OECD (2018) structured survey of 1,093 teachers at universities in Australia, Colombia, the Czech Republic, Denmark, Georgia, Malta, Vietnam, Turkey, and Argentina, examined policy, the practice of cultural characteristics in training specialists, and teachers' attitudes to cultural diversity. Results. The attitude and perception of cultural features by teachers does not determine the practice of forming a cultural environment and managing this environment to ensure quality education of students of different nations. The main culturological aspects of training are self-expression of cultural and ethnic identities, expression of cultural characteristics and their value through multicultural activities in universities, teaching students to combat ethnic or cultural discrimination. Therefore, the formation of a multicultural environment in higher education occurs through the activities of students and teachers, which complement each other. The practical value lies in identifying two important components of the formation of cultural diversity among students, such as self-expression of ethnic and cultural identity and the expression of cultural differences by teachers in the course of educational activities.

Plenary Session l : Efficacy and Safety of Tenofovir DF (TDF) in Chronic Hepatitis B Virus Infected Patients with Documented Lamivudine Resistance (LAM-R)

( S Fung ),( P Kwan ),( A Horban ),( M Pelemis ),( P Husa ),( H W Hann ),( Jf Flaherty ),( B Massetto ),( P Dinh ),( A Corsa ),( K Kitrinos ),( Jg Mchutchison ),( M Fabri ),( E Gane ) 대한간학회 2013 춘·추계 학술대회 (KASL) Vol.2013 No.1

Background: Efficacy and safety of tenofovir DF (TDF) have been demonstrated over 6 years in pivotal HBV studies, but have yet to be established in lamivudine-resistant (LAM-R) patients in a prospective, randomized trial. Methods: Phase 3b, double-blind, randomized (1:1) comparison of TDF and emtricitabine (FTC)/TDF in chronic HBV patients on LAM at screening with HBV DNA ≥103 IU/mL and documented LAM-R (rtM204V/I±rtL180M; INNO-LiPA HBV v2/ v3). Patients were stratified by ALT (≥ or <2×ULN) and HBeAg status. Efficacy and safety, including bone mineral density (BMD) monitoring by DXA were assessed over 96 weeks. Results: Of 280 randomized and treated patients, 133/141 (94%) and 125/139 (90%) in TDF and FTC/TDF groups completed 96 weeks. Groups were well matched: mean age 47 years, 75% males, 34% Asian, 47% HBeAg+, 42% ALT <ULN; HBV genotypes: 22% A, 14% B, 19% C, and 45% D. By ITT analysis, missing=failure, 89% and 86% receiving TDF and FTC/TDF, respectively, had HBV DNA <400 copies/mL at Week 96 (P =0.43); 70% in each arm had normal ALT. HBeAg loss was observed in 10/65 (15%) and 9/68 (13%) in TDF and FTC/TDF arms, respectively. One patient (FTC/TDF) had HBsAg loss without seroconversion. Both treatments were well tolerated with 1% (3/280) discontinuing for adverse event (1 TDF, 2 FTC/TDF). No patients had confirmed increase in serum creatinine of ≥0.5 mg/dL, and 1% (2 TDF) had serum phosphorus <2 mg/dL. BMD of spine and hip revealed no clinically relevant bone loss, and there were no non-traumatic fractures reported. No TDF resistance was detected through 96 weeks. Conclusions: A high rate of HBV DNA suppression with no detectable TDF resistance was achieved with TDF monotherapy in LAM?R patients through 96 weeks. TDF was safe and well tolerated, with a low rate of renal events and no evidence of clinically relevant bone loss.

Plenary Session 1 : PS-1-4 ; Entecavir+adefovir versus lamivudine+adefovir or entecavir alone in lamivudine-resistant chronic hepatitis B: 96-week data from the define study

( Jeong Heo ),( Sang Hoon Ahn ),( Young Oh Kweon ),( Byung Ho Kim ),( Henry Ly Chan ),( Andrzej Horban ),( Suchat Wongcharatrawee ),( Cyril Llamoso ),( Kwan Sik Lee ) 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.1

Background: Unlike the combination of adefovir (ADV) and lamivudine (LVD), currently recommended for treatment of LVD-resistant chronic hepatitis B, both components of an entecavir (ETV)+ADV combination have antiviral activity against LVD-resistant HBV. ETV+ADV may therefore provide antiviral synergy in this challenging population. Methods: In this open-label, multi-center study, 416 HBeAg(+) CHB patients with LVD-resistant HBV were randomized 1:1:1 to receive ETV+ADV (1.0 mg+10 mg), ADV+LDV (10 mg+100 mg) or ETV (1.0 mg) once-daily for 100 weeks. The primary efficacy endpoint was the proportion with HBV DNA <50 IU/mL at Week 48; comparing ETV+ADV to ADV+LVD and ETV monotherapy using the 2-stage Hochberg procedure. At Week 96, the key efficacy endpoint was the difference in proportion <50 IU/ml for ETV+ADV vs ADV+LDV. Subjects who discontinued prior to each analysis were considered failures (NC=F). Results: A total of 415 patients were dosed (76% Korean, 67% male, mean age 44 years). Mean baseline HBV-DNA was 7.4 log10 IU/mL (86% Subtype C, 7% A, 4% B, 3% D, <1% H). At Week 48, proportions <50 IU/mL for ETV+ADV (n=138), ADV+LVD (n=137) and ETV (n=140) were 25.4%, 19.7% and 16.4%, respectively (p=NS). At Week 96, ETV+ADV vs ADV+LDV for <50 IU/mL was 43.5% vs. 28.5% (Difference 15.0%; p=0.0095). Other endpoints are shown in the table below. Conclusions: With 96 weeks of treatment, the antiviral efficacy of ETV+ADV was superior to LVD+ADV. All treatments were well tolerated and had comparable safety profiles.

Efficacy and Safety of Tenofovir DF (TDF) in Chronic Hepatitis B Patients (CHB) with Lamivudine Resistance (LAM-R): 5-year Results

( Florence Wong ),( Scott Fung ),( Hie-won Hann ),( Magdy Elkhashab ),( Thomas Berg ),( Milotka J. Fabri ),( Andrzej Horban ),( Mijomir Pelemis ),( Ioan Sporea ),( John F. Flaherty ),( Benedetta Masse 대한간학회 2016 춘·추계 학술대회 (KASL) Vol.2016 No.1

Aims: In CHB patients with LAM-R, TDF has shown efficacy comparableto FTC/TDF and no detectable TDF resistance at 2 years. The final5 year efficacy and safety results from this trial are presented.Methods: CHB patients on LAM with HBV DNA >3 log10 IU/mL andwith documented LAM-R were randomized (1:1) to TDF or FTC/TDFand followed for 5 years.Results: Two hundred eighty patients were randomized; 232 (83%)completed 5 years of treatment. At baseline, mean age was 47 years,most were male (75%) and non-Asian (66%); 53% were HBeAgnegative. Mean HBV DNA was 5.7 log10 IU/mL and 42% had ALT≤ULN at baseline. At Year 5, virologic, serologic, and biochemicalresponses were similar among groups, and remained stable. Ninepatients (4-TDF, 5-FTC/TDF) discontinued due to an adverse event,including increased serum creatinine in 1 patient. For both groupscombined, confirmed renal safety endpoints over 5 years were: CrCL<50 mL/min in 19 (6.8%) patients (12 requiring dose modification),increases in serum creatinine of ≥0.3 and ≥0.5 mg/dL from baselinein 21 (7.5%) and 2 (0.7%) patients, respectively, and serum phosphorus<2 mg/dL in 3 (1.1%) patients. Mean declines in BMD (g/cm2)from baseline for hip and spine BMD, respectively, were 1.7% and1.5% at Year 2, and 2.5%, and 1% at Year 5. Seven patientsexperienced fracture (all except 1 were trauma-related). No TDF resistancewas detected through 5 years by population sequencing.Conclusions: In LAM R patients with CHB treated for 5 years withTDF, a high rate of HBV DNA suppression was achieved and maintainedwith no detectable TDF resistance. There is no apparent ad advantageof combination FTC/TDF in this population. Renal eventsassociated with TDF occurred in up to 7.5% of patients, and averagelosses in bone mineral density of 1 2.5% were observed.

Plenary Session 1 : PS-1-4 ; Entecavir+adefovir versus lamivudine+adefovir or entecavir alone in lamivudine-resistant chronic hepatitis B: 96-week data from the define study

( Jeong Heo ),( Sang Hoon Ahn ),( Young Oh Kweon ),( Byung Ho Kim ),( Henry Ly Chan ),( Andrzej Horban ),( Suchat Wongcharatrawee ),( Cyril Llamoso ),( Kwan Sik Lee ) 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.-

Background: Unlike the combination of adefovir (ADV) and lamivudine (LVD), currently recommended for treatment of LVD-resistant chronic hepatitis B, both components of an entecavir (ETV)+ADV combination have antiviral activity against LVD-resistant HBV. ETV+ADV may therefore provide antiviral synergy in this challenging population. Methods: In this open-label, multi-center study, 416 HBeAg(+) CHB patients with LVD-resistant HBV were randomized 1:1:1 to receive ETV+ADV (1.0 mg+10 mg), ADV+LDV (10 mg+100 mg) or ETV (1.0 mg) once-daily for 100 weeks. The primary efficacy endpoint was the proportion with HBV DNA <50 IU/mL at Week 48; comparing ETV+ADV to ADV+LVD and ETV monotherapy using the 2-stage Hochberg procedure. At Week 96, the key efficacy endpoint was the difference in proportion <50 IU/ml for ETV+ADV vs ADV+LDV. Subjects who discontinued prior to each analysis were considered failures (NC=F). Results: A total of 415 patients were dosed (76% Korean, 67% male, mean age 44 years). Mean baseline HBV-DNA was 7.4 log10 IU/mL (86% Subtype C, 7% A, 4% B, 3% D, <1% H). At Week 48, proportions <50 IU/mL for ETV+ADV (n=138), ADV+LVD (n=137) and ETV (n=140) were 25.4%, 19.7% and 16.4%, respectively (p=NS). At Week 96, ETV+ADV vs ADV+LDV for <50 IU/mL was 43.5% vs. 28.5% (Difference 15.0%; p=0.0095). Other endpoints are shown in the table below. Conclusions: With 96 weeks of treatment, the antiviral efficacy of ETV+ADV was superior to LVD+ADV. All treatments were well tolerated and had comparable safety profiles.

Safety and Efficacy at 1-Year after Switching from TDF to TAF in CHB Patients with Risk Factors for TDF Use

( Byoung Kuk Jang ),( Edward Gane ),( Wai Kay Seto ),( Harry La Janssen ),( Florin A Caruntu ),( Hyung Joon Kim ),( Dzhamal Abdurakhmanov ),( Shuhei Nishiguchi ),( Andrzej Horban ),( Ho Bae ),( John F 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1

Aims: Tenofovir alafenamide (TAF), a new prodrug of tenofovir (TFV), is now a preferred treatment in the 2017 EASL HBV Guidelines, and may be particularly useful in patients with risk factors for TDF associated renal and bone effects. We assessed the 1 year safety and efficacy in CHB patients with TDF risk factors who were switched from TDF to TAF. Methods: In two identically-designed Phase 3 studies, HBeAg(+) and HBeAg(-)patients were randomized 2:1 to TAF 25 mg or TDF 300 mg and treated in a double- blind fashion for 96 weeks; all patients received open-label (OL) TAF for an additional 48 weeks (through Week 144). Renal and bone safety parameters, and antiviral efficacy (HBV DNA < 29 IU/mL) and ALT normalization were assessed in the subset of switch patients with baseline risk factors for TDF use: Age >60 years, osteoporosis of hip or spine, ³Stage 2 CKD (GFRCG < 90 mL/ min), albuminurina (UACR >30 mg/g), hypophosphatemia (PO4 <2.5 mg/dL), or presence of comorbidities (e.g. HTN, DM). Results: Of 1298 patients randomized and treated in the 2 studies, 540(42%) switched to open- label TAF at Week 96 (TAF^®TAF 360; TDF^®TAF 180), of which 284(53%) patients had at least 1 TDF risk factor at baseline; 123(23%) patients had ³2 risk factors. Baseline demographics and disease characteristics were similar between treatment groups. At Week 144, significant improvements in renal (sCr, eGFRCG) parameters, hip and spine BMD were observed and summarized in the table. Antiviral efficacy was maintained at Week 144 in both groups and in TDF patients who switched to TAF, increased rates of ALT normalization were seen. Conclusions: In CHB patients with risk factors for potential TDF toxicity, switching from TDF to TAF resulted in improved bone and renal safety parameters while efficacy was maintained in this subgroup at one year.