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- 저자 : Hongxia Xiang (검색결과 4 건)
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Isovitexin Is a Direct Inhibitor of Staphylococcus aureus Coagulase
( Hua Xiang ),( Panpan Yang ),( Li Wang ),( Jiaxin Li ),( Tiedong Wang ),( Junze Xue ),( Dacheng Wang ),( Hongxia Ma ) 한국미생물 · 생명공학회 2021 Journal of microbiology and biotechnology Vol.31 No.10
Staphylococcus aureus (S. aureus) is a major pathogen that causes human pneumonia, leading to significant morbidity and mortality. S. aureus coagulase (Coa) triggers the polymerization of fibrin by activating host prothrombin, which then converts fibrinogen to fibrin and contributes to S. aureus pathogenesis and persistent infection. In our research, we demonstrate that isovitexin, an active traditional Chinese medicine component, can inhibit the coagulase activity of Coa but does not interfere with the growth of S. aureus. Furthermore, we show through thermal shift and fluorescence quenching assays that isovitexin directly binds to Coa. Dynamic simulation and structure-activity relationship analyses suggest that V191 and P268 are key amino acid residues responsible for the binding of isovitexin to Coa. Taken together, these data indicate that isovitexin is a direct Coa inhibitor and a promising candidate for drug development against S. aureus infection.
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Effects of air-impingement jet drying on drying kinetics and quality retention of tomato slices
Si Tan,Yiwen Miao,Hongxia Xiang,Weihua Tan,Wenfeng Li 한국식품과학회 2021 Food Science and Biotechnology Vol.30 No.5
The purpose was to explore the drying kinetics,the moisture effective diffusivities, color, total polyphenols,lycopene and antioxidant activities of dried tomatoslices by air-impingement jet drying (AIJD). The resultsshowed that high temperature increased the drying rate, andModified Page model accurately predicted the AIJD characteristicsof tomato slices. AIJD is better than hot airdrying in shortening drying time, enhancing drying rate anddecreasing the loss of total polyphenols, lycopene andantioxidant capacity of tomato slices. Tomato slices driedby AIJD also showed higher lightness and redness. Lycopenecontent and antioxidant activity of tomato slices driedby AIJD were increased by higher drying temperature. Based on experimental data, AIJD at 80 C can be used intomato drying process due to the advantages in dryingefficiency and content of bioactive compounds. This studywill provide helpful information for the production of highquality of dried tomato products.
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Simultaneous removal of Congo red and Cr(VI) using amino-modified GO/MS composite materials
Liang Cheng,Li Zhang,Hongxia Wang,Fang Xiang Song 한국화학공학회 2022 Korean Journal of Chemical Engineering Vol.39 No.5
Mesoporous silica (MS) and graphene oxide (GO) are good absorbents. Combining them not only preventsGO agglomeration but increases the number of MS active sites. In addition, their composites can preferentiallyadsorb specific pollutants after modification. In this work, amino-modified GO/MS materials were prepared by postgraftingto remove Congo red (CR) and Cr(VI) in solution. Characterization methods, such as X-ray diffraction (XRD),transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FTIR), Zeta potential, and N2adsorption/desorption, were adopted. The prepared GO/MS@HBP has a porous structure with a specific surface areaof 49.32m2·g1. The effect of initial concentration, pH, adsorption time, temperature and other ions was determined onthe adsorption amount. Relying on this, the GO/MS@HBP maximum capacity for Cr(VI) and CR adsorption are93.73±2.3% and 257.69+1.5% mg·g1, respectively. Pseudo-second-order kinetic and Langmuir isotherms are moresuitable to describe the adsorption process, indicating that chemical adsorption plays a major role in the entire adsorptionprocess. Thermodynamics showed that the enthalpy (H) of materials adsorbing two pollutants was positive andthat the Gibbs free energy (G) was negative, suggesting that Cr(VI) and CR adsorption on GO/MS@HBP was spontaneouslyendothermic. GO/MS@HBP could simultaneously remove CR and Cr(VI) in solution, and be an effectiveadsorbent for removing harmful substances.
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Yuanyun Wei,Yaqi Gong,Shuang Wei,Yonglin Chen,Jian Cui,Xiang Lin,Yueqiu Yu,Hongxia Yan,Hui Qin,Lan Yi 대한약학회 2022 Archives of Pharmacal Research Vol.45 No.8
Sometimes, people can be exposed to moderateor high doses of radiation accidentally or through the environment. Radiation can cause great harm to several systemswithin organisms, especially the hematopoietic system. Severaltypes of drugs protect the hematopoietic system againstradiation damage in diff erent ways. They can be classifi edas “synthetic drugs” and “natural compounds.” Their cellularmechanisms to protect organisms from radiation damageinclude free radical-scavenging, anti-oxidation, reducinggenotoxicity and apoptosis, and alleviating suppression ofthe bone marrow. These topics have been reviewed to providenew ideas for the development and research of drugsalleviating radiation-induced damage to the hematopoieticsystem.
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