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- 저자 : Hongsheng Yin (검색결과 4 건)
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A Cooperative Coevolution Algorithm Based on ABC and NMSM
Hongsheng Su,Kaile Yin,Zihan Wu 보안공학연구지원센터 2016 International Journal of Hybrid Information Techno Vol.9 No.12
Considering that the existing artificial bee colony (ABC) algorithm can not give simultaneously attention to evolution speed and solution quality, an improved ABC algorithm is proposed based on nelder-mead simplex method (NMSM) in this paper, and defined ad NMSM-ABC. In the process of iteration, the algorithm periodically passes the best individual vertex from NMSM operator into ABC, or migrates the optimal food source information from ABC to NMSM can get away from local minimum with aid of ABC. Hence, the proposed algorithm can realize cooperative co-evolution of the two so that the desired properties are obtained. In addition, the sensitivity analysis of the key parameter of NMSM-ABC is also conducted and the best value is suggested. Finally, Numerical experiments and comparisons on 6 benchmark functions are conducted with other ABC algorithms, and the results indicate that the proposed algorithm effectively overcomes the local minimum, and dramatically enhances the global searching ability and convergence speed, and is a good cooperative co-evolution algorithm.
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Hongsheng Liang,Xiangtong Zhang,Yibo Yin,Tie Lin,Dong Guan,Bowen Ma,Changyu Li,Yuehua Wang 한국분자세포생물학회 2013 Molecules and cells Vol.36 No.1
The reorganization of brain structures after intracerebral hemorrhage (ICH) insult is crucial to functional outcome. Although the pattern of neuronal rewiring is well-docu-mented after ischemic stroke, the study of brain plasticity after ICH has been focusing on the enhancement of dendritic complexity. Here we hypothesized that functional restoration after ICH involves brain reorganization which may be favorably modulated by stem cell transplantation. In this study, bone marrow stromal cells (BMSCs) were transplanted into the perilesional sites of collagenase-induced ICH in adult rats one day after ICH injury. Forelimb functional recovery was monitored with modified limb placing and vibrissae-elicited forelimb placement tests. Anterograde and retrograde tracing were used to assess the reorganization of bilateral forelimb areas of the sen-sorimotor cortex. We found that in rats transplanted with BMSCs after ICH injury, axonal sprouting occurred in the contralateral caudal forelimb area of the cortex, and was significantly higher than in ICH rat models that received only the vehicle (P < 0.01). The number of positive neurons in the ipsilateral rostral forelimb area of the cortex of the BMSC group was 1.5- to 4.5-fold greater than in the vehicle group (P < 0.05). No difference was found between the BMSC and vehicle groups in hemispheric atrophy or labeled neurons in the ipsilateral caudal forelimb area (P = 0.193). Scores for improved functional behavior in the BMSC group were in accord with the results from histology. Neuronal plasticity of the denervated corticospinal tract at bilateral forelimb areas of the cortex in the collagenase-induced ICH rat models was significantly enhanced by BMSC transplantation. BMSC transplantation may facilitate functional recovery after ICH injury.
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Chunyu Zhu,Fangliang Zheng,Sugai Yin,Hongsheng Liu,Yan Liu,Maosheng Zhang,Shuqin Xiong 한국유전학회 2014 Genes & Genomics Vol.36 No.6
The baculovirus ChaB proteins are conservedin all completely sequenced Lepidopteran NPVs and areannotated as putative DNA binding proteins. In our previousstudy, ORF51, a ChaB homologue from Helicoverpaarmigera single nucleocapsid nucleopolyhedrovirus(HearNPV) was found to be involved in budded virusproduction and DNA replication. In the present study, wecharacterized ORF52 (Ha52), the other ChaB homologousgene in HearNPV. 50-RACE revealed that Ha52 was transcribedfrom a conventional late promoter transcriptionalinitiator motif (TAAG) located 25 nucleotides upstream ofATG. Expression analysis demonstrated that HA52 proteinwas expressed from 48 to 96 h post infection. Western blotanalysis of virions from both budded viruses (BVs) andocclusion-derived viruses (ODVs) indicated that HA52 wasa structural component of nucleocapsid from ODV. Tostudy the function of Ha52 in the life cycle of HearNPV,Ha52-knockout and Ha52-restored viruses were generatedby the Bac-to-Bac system. Growth curve analyses showedthat the level of BV production in cells infected with Ha52null virus was similar to those infected with wild-typebacmid derived virus. However, bioassay showed thatdeletion of Ha52 significantly decreased the per os infectivityof HearNPV. Taken together, our results indicatedthat, unlike the previously characterized baculovirual ChaBgenes, Ha52 may be involved in HearNPV per os infection.
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