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구성태,송문영,강정묵,김용명,박보라,이은석,홍정아,김경식,손인철 한국전통의학연구소 2003 한국전통의학지 Vol.13 No.1
Literally, the mean of Tae-gye is highest brook. And on the basis of the acupuncture theory, Tae-gye point is the Soo earth point and source point of the Kidney Channel as well. In addition, Tae-gye point is one of the Yang-Returning Nine points. We were trying to study bibliographically on the Tae-gye point because Tae-gye point can be used very broadly across the symptoms in the theoretical aspect described above. As a results, we found out that according to the classical books of acupuncture, Tae-gye point is entering point of the Meridian Water as a source point and can be used at both Kidney-Sufficient Syndrom and Kidney-Deficient Syndrom. And Tae-gye can be applied to the disease of kidney or bladder that is urogenital symtoms, Also, Tae-gye is an useful option of tooth-ache, asthma, indigestion, constipation, edema etc whose cause is related with decrease of Kidney ki.
이만웅,배홍석,이보근,송서일 동아대학교 공과대학 부설 한국자원개발연구소 1995 硏究報告 Vol.19 No.2
In the rectifying single sampling inspection, 9-sampling inspection methods are briefly described, and then the optimal inspection plan to minimize the expected total cost is derived. The results of this experiment through numerical example are: (1) The optimal inspection plan of sampling to minimize the cost with several variables is derived. The result is TC(134, 4)=2321. (2) The optimal inspection plan is obtained when the LTPD is increased, and the sample size, acceptance number and total cost are decreased. (3) The optimal inspection plan is obtained when the lot size is increased, and sample size and acceptance number are also increased. (4) When e₁ is fixed and e₂ is increased, p_(e) is decreased with very small erefore, the type -Ⅰ error must influences on sample size more than the type-Ⅱ error does.
Lee, Song Hee,Choi, Bo Young,Kho, A Ra,Jeong, Jeong Hyun,Hong, Dae Ki,Kang, Dong Hyeon,Kang, Beom Seok,Song, Hong Ki,Choi, Hui Chul,Suh, Sang Won MDPI 2018 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol.19 No.10
<P>Apocynin, also known as acetovanillone, is a natural organic compound structurally related to vanillin. Apocynin is known to be an inhibitor of NADPH (Nicotinamide adenine dinucleotide phosphate) oxidase activity and is highly effective in suppressing the production of superoxide. The neuroprotective effects of apocynin have been investigated in numerous brain injury settings, such as stroke, traumatic brain injury (TBI), and epilepsy. Our lab has demonstrated that TBI or seizure-induced oxidative injury and neuronal death were reduced by apocynin treatment. Several studies have also demonstrated that neuroblast production is transiently increased in the hippocampus after seizures. Here, we provide evidence confirming the hypothesis that long-term treatment with apocynin may enhance newly generated hippocampal neuronal survival by reduction of superoxide production after seizures. A seizure was induced by pilocarpine [(25 mg/kg intraperitoneal (i.p.)] injection. Apocynin was continuously injected for 4 weeks after seizures (once per day) into the intraperitoneal space. We evaluated neuronal nuclear antigen (NeuN), bromodeoxyuridine (BrdU), and doublecortin (DCX) immunostaining to determine whether treatment with apocynin increased neuronal survival and neurogenesis in the hippocampus after seizures. The present study indicates that long-term treatment of apocynin increased the number of NeuN<SUP>+</SUP> and DCX<SUP>+</SUP> cells in the hippocampus after seizures. Therefore, this study suggests that apocynin treatment increased neuronal survival and neuroblast production by reduction of hippocampal oxidative injury after seizures.</P>
Song, Ki-Hoon,Song, Dae-Hae,Lee, Jeong-Ran,Kim, Goon-Bo,Choi, Hong-Kyu,Penmetsa, R. Varma,Nam, Young-Woo The Korean Society of Crop Science 2007 Korean journal of crop science Vol.52 No.4
To tolerate environmentally adverse conditions such as cold, drought, and salinity, plants often synthesize and accumulate proline in cells as compatible osmolytes. ${\Delta}^1$-Pyrroline-5-carboxylate synthetase(P5CS) catalyzes the rate-limiting step of proline biosynthesis from glutamate. Two complete genes, MtP5CS1 and MtP5CS2, were isolated from the model legume Medicago truncatula by cDNA cloning and bacterial artificial chromosome library screening. Nucleotide sequence analysis showed that both genes consisted of 20 exons and 19 introns. Alignment of the predicted amino acid sequences revealed high similarities with P5CS proteins from other plant species. The two MtP5CS genes were expressed in response to high salt and low temperature treatments. Semi-quantitative reverse transcription-polymerase chain reaction showed that MtP5CS1 was expressed earlier than MtP5CS2, indicating differential regulation of the two genes. To evaluate the reverse genetic effects of nucleotide changes on MtP5CS function, a Targeting Induced Local Lesions in Genomes approach was taken. Three mutants each were isolated for MtP5CS1 and MtP5CS2, of which a P5CS2 nonsense mutant carrying a codon change from arginine to stop was expected to bring translation to premature termination. These provide a valuable genetic resource with which to determine the function of the P5CS genes in environmental stress responses of legume crops.
Characterization of a Novel Monoclonal Antibody (27H2) Recognizing Human CD34 Class III Epitope
Hong, Kwon-Pyo,Kang, Sung-Hee,Lee, Kyoung-Mee,Ji, Gil-Yong,Yoon, Sang-Soon,Kim, Jong-Suk,Son, Bo-Ra,Lee, Dong-Geun,Lee, Ok-Jun,Song, Hyung-Geun The Korean Association of Immunobiologists 2010 Immune Network Vol.10 No.6
Background: Monoclonal antibodies (mAbs) recognizing Class III epitope of CD34 are essential for flow cytometric diagnosis of leukemia. Methods: 27H2 mAb was developed from a mouse alternatively immunized with human acute leukemia cell lines, KG1 and Molm-1. Using flow cytometric analysis of various leukemic cell lines and peripheral blood, immunohistochemical study of frozen tonsil, we characterized 27H2 mAb. Antigen immunoprecipitated with 27H2 mAb immunobloted with anti-CD34 mAb. A case of bone marrow sample of acute lymphoblastic leukemia (ALL) patient was obtained at CBNU Hospital. For epitope identification enzyme treatment with neuraminidase and O-sialoglycoprotein endopeptidase (OSGE) and blocking assay with known classIII mAb (HPCA-2) were done. Results: Only KG1 and Molm-1 revealed positive immunoreactivity. Immunohistochemical staining disclosed strong membranous immunoreactivity on high endothelial venules. Antigen immunoprecipitated by 27H2 mAb showed approximately 100 kDa sized band immunoblotted with anti-CD34 under non-reducing conditions. Epitope recognized by 27H2 mAb disclosed resistancy to both neuraminidase and OSGE treatment and completely blocked with known class III mAb preincubation. CD34 positive leukemic cells in BM of pre B cell ALL patient detected by FITC-conjugated 27H2 and HPCA-2 were identified with similar sensitivity. Conclusion: A novel murine mAb recognizing class III epitope of human CD34 with high affinity, which is useful for flow cytometric diagnosis of leukemia, was developed.
Bo-Gyeong Yoo,Jun-Pyo Hong,Ha-Yeon Song,Eui-Hong Byun 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
Protaetia brevitarsis seulensis (P. brevitarsis) larvae has been used as alternative medicine. Although various health benefits have been reported, immunomodulatory effects of P. brevitarsis extract are still unknown. In this study, the immuno-enhancing activity of P. brevitarsis larvae hot-water extract (PLW) was investigated using RAW264.7 macrophage cell line. PLW did not exert cytotoxicity at concentrations ranging from 1 to 200 μg/mL in RAW264.7 cells. The treatment of PLW increased the production of nitric oxide and cytokines (tumor necrosis factor-alpha and interleukin-6) at dose ranging from 100 to 200 μg/mL in RAW264.7 cells. Additionally, treatment of PLW (100, 200 μg/mL) led to the increase of surface molecules (cluster of differentiation 80/86 and major histocompatibility complex-class Ⅰ/Ⅱ) expression in RAW264.7 cells. These immunomodulatory effects of PLW was mediated by mitogen activated protein kinases (extracellular signal-regulated kinase, Jun N-terminal kinase, p38 MAPK) phosphorylation and nuclear factor-κB translocation. In conclusion, these findings provide experimental evidence that PLW can be used as an immune-enhancing nutraceutical ingredient.
Serum Elastin-Derived Peptides and Anti-Elastin Antibody in Patients with Systemic Sclerosis
Hong, Yoo Jin,Kim, Jinhyun,Oh, Bo Ram,Lee, Yun Jong,Lee, Eun Young,Lee, Eun Bong,Lee, Seung-Hyo,Song, Yeong Wook The Korean Academy of Medical Sciences 2012 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.27 No.5
<P>The elastin metabolism in systemic sclerosis (SSc) has been known to be abnormal. The authors investigated relationship between the clinical manifestations of systemic sclerosis (SSc) and serum levels of soluble elastin-derived peptide (S-EDP) and anti-elastin antibodies. Serum samples were obtained from 79 patients with SSc and 79 age- and sex-matched healthy controls. Concentrations of serum S-EDP and anti-elastin antibodies were measured by ELISA. The serum concentrations of S-EDP in SSc patients were significantly higher than in healthy controls (median, 144.44 ng/mL vs 79.59 ng/mL, <I>P</I> < 0.001). Serum EDP concentrations were found to be correlated with disease duration in SSc (<I>P</I> = 0.002) and particularly in diffuse cutaneous SSc (<I>P</I> = 0.005). Levels of anti-elastin antibodies were found to be more elevated in SSc patients than in healthy controls (median, 0.222 U vs 0.191 U, <I>P</I> = 0.049), more increased in diffuse cutaneous SSc than limited cutaneous SSc (median, 0.368 U vs 0.204 U, <I>P</I> = 0.031). In addition, levels of anti-elastin antibodies were also found to be negatively associated with presence of anti-centromere antibody (<I>P</I> = 0.023). The S-EDP levels were not found to be correlated with levels of anti-elastin antibodies. The increased S-EDP and anti-elastin antibody levels and association with clinical and laboratory characteristics may reflect the abnormal metabolism in SSc.</P>