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60세 이상 여성노인의 심혈관계 위험인자와 인지장애 및 우울증과의 연관성
홍혜련(Haeryun Hong),강현식(Hyunsik Kang) 한국생활환경학회 2020 한국생활환경학회지 Vol.27 No.4
In this cross-sectional study, we examined the effect of cardiovascular risk factors on cognitive impairment and depressive symptoms in older Korean women aged 60 years and older (N=3,034). Cardiovascular risk factors included smoking, heavy alcohol consumption, physical inactivity, underweight/obesity, unintentional weight loss. Cognitive impairment and depressive symptoms were assessed with Mini-Mental Status of Examination and Center for Epidemiological Studies of Depression 10, respectively. Logistic regression analyses showed that odds ratio (OR) of cognitive impairment was 2.79 (95% confidence interval, CI, 2.220∼3.515, p<0.001), 2.97 (95% CI, 2.323~3.793, p<0.001), and 4.38 (95% CI, 2.861~6.711, p<0.001) for one, two, and three and more risk factors. The ORs of one and two risk factors for cognitive impairment remained significant even after adjustments for age, body mass index, income, education, religion, type of house, impaired activities of daily living, fall experience, hospitalization, and medications. The OR of depression was 1.81 (95% CI, 1.439~2.272, p<0.001), 2.24 (95% CI, 1.757~2.585, p<0.001), and 3.44 (95% CI, 2.268~5.207, p<0.001) for one, two, and three and more risk factors. The ORs of one, two, three and more risk factors for depression remained significant even after adjustments for all the covariates.
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Insulin Resistance and Its Association with Metabolic Syndrome in Korean Children
Cho, Jinkyung,Hong, Haeryun,Park, Soohyun,Kim, Shinuk,Kang, Hyunsik Hindawi 2017 BioMed research international Vol.2017 No.-
<P><B>Background</B></P><P> This study investigated the association between insulin resistance (IR) and metabolic syndrome (MetS) in children.</P><P><B> Methods</B></P><P> A cross-sectional study involving 1036 healthy children aged between 7 and 13 years was conducted. Homeostasis model assessment of insulin resistance (HOMA-IR) was calculated as an index of IR. Participants were classified according to the HOMA-IR quartiles.</P><P><B> Results</B></P><P> Incremental, linear trends were found in age (<I>p</I> < 0.001), body mass index (BMI) (<I>p</I> < 0.001), body fat (<I>p</I> < 0.001), waist circumference (<I>p</I> < 0.001), resting blood pressures (BP) (<I>p</I> < 0.001), triglycerides (TG) (<I>p</I> < 0.001), total cholesterol (TC) (<I>p</I> < 0.001), high density lipoprotein-cholesterol (HDL-C) (<I>p</I> < 0.001), FBG (<I>p</I> < 0.001), and insulin (<0.001) according to incremental HOMA-IR categories (from the 1st to 4th quartile). Compared with children in the 1st HOMA-IR quartile, children in the 4th HOMA-IR quartile had significantly higher odd ratios (ORs) of abnormalities in systolic (<I>p</I> = 0.051) and diastolic BP (<I>p</I> = 0.005), FBG (<I>p</I> < 0.001), TG (<I>p</I> < 0.001), TC (<I>p</I> = 0.016), and HDL-C (<I>p</I> = 0.006) even after adjustments for age, gender, BMI, and body fat percentage. Children in the 3rd HOMA-IR quartile had significant abnormalities in FBG (<I>p</I> < 0.001), TG (<I>p</I> = 0.001), and HDL-C (<I>p</I> = 0.010) even after adjustments for the covariates.</P><P><B> Conclusion</B></P><P> The current findings suggest that IR is significantly associated with the clustering of MetS risk factors in children in Korea. </P>
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Sarcopenia Is Associated with Cognitive Impairment and Depression in Elderly Korean Women
LEE, Inhwan,CHO, Jinkyung,HONG, Haeryun,JIN, Youngyun,KIM, Donghyun,KANG, Hyunsik Tehran University of Medical Sciences 2018 Iranian journal of public health Vol.47 No.3
<P><B>Background:</B></P><P>Sarcopenia has been implicated in the increased risk for cognitive impairment and depression associated with aging. In this cross-sectional study, we investigated the relationship of sarcopenia with cognitive impairment (MCI) and depression in a sample of 201 community-dwelling Korean women (mean age of 74.0±6.8 yr) between 2014 and 2015.</P><P><B>Methods:</B></P><P>The Korean version of mini-mental state examination and the center for epidemiologic studies depression scale was used to assess cognitive performance and depression, respectively. Grp strength was measured with a dynamometer. Demographics, body composition, education, alcohol consumption, and history of cardiovascular diseases were assessed as covariates.</P><P><B>Results:</B></P><P>Odds ratio (OR) and 95% confidence interval (95% CI) of MCI and depression were calculated according to sarcopenia status. Compared to non-sarcopenic, pre-sarcopenic and sarcopenic women had the ORs of 2.160 (95% CI of 0.840 – 5.554, <I>P</I>=0.030) and of 5.493 (95% CI of 1.854 – 16.270, <I>P</I>=0.002) for MCI. The OR of pre-sarcopenia for MCI remained significant (<I>P</I>=0.030) even after adjustments for age, body mass index (BMI), lean body mass, and education, while the OR of sarcopenia for MCI was no longer significant (<I>P</I>=0.084) when adjusted for the covariates. Compared to non-sarcopenic, pre-sarcopenic and sarcopenic women had the ORs of 3.750 (95% CI of 1.137 – 12.370, <I>P</I>=0.030) and of 4.687 (95% CI of 1.127–19.505, <I>P</I>=0.034) for depression. The ORs of pre-sarcopenia and sarcopenia for depression remained statistically significant (<I>P</I>=0.020 and <I>P</I>=0.042, respectively) even after adjusted for the covariates</P><P><B>Conclusion:</B></P><P>Sarcopenia was significantly associated with MCI and depression in otherwise healthy community dwelling elderly Korean women.</P>
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