Insulin Resistance and Its Association with Metabolic Syndrome in Korean Children

다국어 초록 (Multilingual Abstract)

<P><B>Background</B></P><P> This study investigated the association between insulin resistance (IR) and metabolic syndrome (MetS) in children.</P><P><B> Methods</B></P><P> A cross-sectional study involving 1036 healthy children aged between 7 and 13 years was conducted. Homeostasis model assessment of insulin resistance (HOMA-IR) was calculated as an index of IR. Participants were classified according to the HOMA-IR quartiles.</P><P><B> Results</B></P><P> Incremental, linear trends were found in age (<I>p</I> < 0.001), body mass index (BMI) (<I>p</I> < 0.001), body fat (<I>p</I> < 0.001), waist circumference (<I>p</I> < 0.001), resting blood pressures (BP) (<I>p</I> < 0.001), triglycerides (TG) (<I>p</I> < 0.001), total cholesterol (TC) (<I>p</I> < 0.001), high density lipoprotein-cholesterol (HDL-C) (<I>p</I> < 0.001), FBG (<I>p</I> < 0.001), and insulin (<0.001) according to incremental HOMA-IR categories (from the 1st to 4th quartile). Compared with children in the 1st HOMA-IR quartile, children in the 4th HOMA-IR quartile had significantly higher odd ratios (ORs) of abnormalities in systolic (<I>p</I> = 0.051) and diastolic BP (<I>p</I> = 0.005), FBG (<I>p</I> < 0.001), TG (<I>p</I> < 0.001), TC (<I>p</I> = 0.016), and HDL-C (<I>p</I> = 0.006) even after adjustments for age, gender, BMI, and body fat percentage. Children in the 3rd HOMA-IR quartile had significant abnormalities in FBG (<I>p</I> < 0.001), TG (<I>p</I> = 0.001), and HDL-C (<I>p</I> = 0.010) even after adjustments for the covariates.</P><P><B> Conclusion</B></P><P> The current findings suggest that IR is significantly associated with the clustering of MetS risk factors in children in Korea. </P>