Effects of Compounds from Physalis angulata on Fatty Acid Synthesis and Glucose Metabolism in HepG2 Cells via the AMP-activated Protein Kinase Pathway

Hoang Thai Hoa,Nguyen Thi Thu,Nguyen Thuong Dong,Tran Thi Oanh,Tran Thi Hien,Do Thi Ha 한국생약학회 2020 Natural Product Sciences Vol.26 No.3

The ability of the total extract from Physalis angulata; three fractions after partitioning with n-hexane, ethyl acetate (TBE), and water; and four withanolides (compounds 1 – 4) to phosphorylate 5'-adenosine monophosphate-activated protein kinase (AMPK) and acetyl-CoA carboxylase (ACC) in HepG2 cells was evaluated. The TBE fraction (50 μg/mL) activated p-ACC and p-AMPK expression most strongly. Compounds 1 – 4 (10 μM) upregulated p-ACC expression at different levels. Compound 4 induced the most significant changes in p-AMPK expression, followed by 1 and 2. Sterol regulatory element-binding proteins (SREBPs) play a functional role in the transcriptional regulation of the lipogenic pathway, including fatty acid synthase (FAS) and ACC. The effects of compounds 2 and 4 (10 μM) on FAS and SREBP-1c expression under high glucose conditions (30 mM) in HepG2 cells were evaluated further. Both dose-dependently inhibited FAS and SREBP-1c expression as well as lipid accumulation (1 – 10 μM) were compared to high-concentration glucose control, which upregulated FAS and SREBP-1c. These results suggest that compounds 2 and 4 upregulate AMPK, suppress FAS and SREBP-1c, and have potential effects on glucose and lipid metabolism.

Miniaturized Capacitively Loaded Step-Impedance Bandpass Filter in Multilayer Substrate

Thai Hoa, Duong,Dinh Chien, Hoang,Kim, Ihn Seok 慶熙大學校 레이저 工學硏究所 2007 레이저공학 Vol.18 No.-

In this paper, a miniaturized low insertion loss interdigital bandpass filter with capacitively loaded stepped impedance resonators (SIR) in Low Temperature Co-fired Ceramic (LTCC) technology is introduced. By using SIR and capacitive loading structures based on 6_(r) = 41.77 substrates, a wideband interdigital bandpass filter has been realized for the frequency range from 3.1 GHz to 4.8 GHz. Measurement shows insertion loss less than 0.8 dB, return loss better than 15 dB in the pass band with the center frequency at 3.95 GIIz and bandwidth ratio of 43 %. The filter has a size of 2.15 × 2.6 × 0.85㎣.

The Antecedents Of Brand Love Toward Natural Products: An Approach of S.O.R Theory

Le Thai Hoa NGUYEN,Hoang Anh NGUYEN 한국유통과학회 2022 Asian Journal of Business Environment (AJBE) Vol.12 No.2

Purpose: Natural products are becoming gradually popular because of their health - related benefits and consumers’ environmental awareness. However, research in this field remains limited, the present study attempts to address this research gap by measuring the influencing levels of the antecedents on natural product brand love. Research design, data and methodology: The study employs S-O-R (Stimulus - Organism - Response) framework together with Innovation Resistance Theory and Dual-Factor Theory to propose the research model, in which health and environmental stimuli influence both of facilitators and inhibitors of internal states or organism, and then shape purchase intention and brand love as consumers’ responses. The mixed research method is designed with the application of structural equation model (SEM) to analyze 530 consumers collected by convenience sampling. Results: The results revealed that two chosen stimuli, including health awareness and environmental concern were positively related to both facilitators (natural content and regional products) and inhibitors (image barrier and usage barrier) and these four factors were significantly associated to purchase intention and brand love. Furthermore, purchase intention played the mediating role on the relationship between the four organisms and brand love. Conclusions: The originality of this paper is extend S-O-R theory into natural product context with mediating effects in an emerging economy. The findings make theoretical contribution on consumer behavior and managerial implication.

The Antecedents Of Brand Love Toward Natural Products: An Approach of S.O.R Theory

NGUYEN, Le Thai Hoa,NGUYEN, Hoang Anh Korea Distribution Science Association 2022 Asian journal of business environment Vol.12 No.2

Purpose: Natural products are becoming gradually popular because of their health - related benefits and consumers' environmental awareness. However, research in this field remains limited, the present study attempts to address this research gap by measuring the influencing levels of the antecedents on natural product brand love. Research design, data and methodology: The study employs S-O-R (Stimulus - Organism - Response) framework together with Innovation Resistance Theory and Dual-Factor Theory to propose the research model, in which health and environmental stimuli influence both of facilitators and inhibitors of internal states or organism, and then shape purchase intention and brand love as consumers' responses. The mixed research method is designed with the application of structural equation model (SEM) to analyze 530 consumers collected by convenience sampling. Results: The results revealed that two chosen stimuli, including health awareness and environmental concern were positively related to both facilitators (natural content and regional products) and inhibitors (image barrier and usage barrier) and these four factors were significantly associated to purchase intention and brand love. Furthermore, purchase intention played the mediating role on the relationship between the four organisms and brand love. Conclusions: The originality of this paper is extend S-O-R theory into natural product context with mediating effects in an emerging economy. The findings make theoretical contribution on consumer behavior and managerial implication.

Vingroup: The Rising Dragon That Put Vietnam on the Global Map

Giap Vu Nam Duong,Hoang Khanh Linh,정경화,Nguyen Khanh Linh,Nguyen Phuong Hoa,Phan Hai Dang,Thai Thi Phuong Nga Academy of Asian Business (AAB) 2022 Academy of Asian Business Review Vol.8 No.1

Vingroup JSC (formerly Technocom) was founded in Ukraine in 1993 as an instant noodle factory. Since then, the Group has expanded into many other industries, placing tourism and hospitality as their first stepping-stone, then venturing into retail, real estate, education, and recently shifting towards a promising industrial and technology industry. Vingroup has now become the largest conglomerate in Vietnam in terms of market capitalization (VnExpress International, 2019). Having established a solid foundation in the Vietnamese market, Vingroup is eyeing the new promising yet challenging international market, with its competitive advantage in industrials and technology. Standing at a crucial juncture in its ascent, the conglomerate must implement a comprehensive and long-term strategy to reach its next milestone. In 2016, Vingroup primarily focused on four main business segments, encompassing property, hospitality - entertainment, consumer retail, and social infrastructure services. Over the course of two decades, Vinpearl and Vincom have grown into the market-leading hospitality and shopping malls brand in Vietnam. The brands’ establishment coincided with the flourishing economy of the country in the early 2000s, therefore, quickly achieved market dominance. Having such favorable conditions, the Group continued its expansion and investment in other backboned industries, which has reaped correspondingly fruitful results. The key success factors of Vingroup lies in an entrepreneurial mindset, speed, perfectionism and discipline, and last but not least, the national spirit. These traits have allowed the Group to unleash its potential capabilities and go beyond all boundaries. Both small-and-medium-sized companies and big firms can take Vingroup as a lesson for their strategy and corporate culture so that they can lead successful and sustainable growth in today’s competitive market.

Enhanced electrosorption of NaCl and nickel(II) in capacitive deionization by CO2 activation coconut-shell activated carbon

Huynh Le Thanh Nguyen,Tran Thanh Nhut,Ho Thi Thanh Nguyen,Le Xuan Hoa,Le Viet Hai,Nguyen Thai Hoang 한국탄소학회 2022 Carbon Letters Vol.32 No.6

Enhancing the capacitive deionization performance requires the inner structure expansion of porous activated carbon to facilitate the charge storage and electrolyte penetration. This work aimed to modify the porosity of coconut-shell activated carbon (AC) through CO2 activation at high temperature. The electrochemical performance of CO2-activated AC electrodes was evaluated by cyclic voltammetry, charge/discharge test and electrochemical impedance spectroscopy, which exhibited that AC-800 had the superior performance with the highest capacitance of 112 F/g at the rate of 0.1 A/g and could operate for up to 4000 cycles. Furthermore, in the capacitive deionization, AC-800 showed salt removal of 9.15 mg/g with a high absorption rate of 2.8 mg/g min and Ni(II) removal of 5.32 mg/g with a rate close to 1 mg/g.min. The results promote the potential application of CO2-activated AC for desalination as well as Ni-removal through capacitance deionization (CDI) technology.