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Successful Management of Clozapine-induced Akathisia with Gabapentin Enacarbil: A Case Report
Masahiro Takeshima,Hiroyasu Ishikawa,Yuka Kikuchi,Takashi Kanbayashi,Tetsuo Shimizu 대한정신약물학회 2018 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.16 No.3
The management of clozapine (CLZ)-induced adverse events affects patient prognoses. Akathisia is a relatively rare adverse event related to CLZ administration and thus the management of this syndrome is not well established. Here, we report a case of treatment-resistant schizophrenia wherein CLZ-induced akathisia was successfully managed with gabapentin enacarbil (GE). The patient was a 39-year-old woman who had been treated with atypical antipsychotics other than CLZ for three years with poor tolerability. Initiation of CLZ (400 mg/day) attenuated her psychotic symptoms, but was followed by moderate akathisia. Neither benzodiazepines nor biperiden improved the akathisia; however, akathisia was finally diminished with co-administration of GE. GE facilitated a dosage increase in CLZ (450 mg/day) for the improved management of pyschotic symptoms, and thus indirectly contributed to treatment of the patient’s schizophrenia. We suggest that GE is a useful candidate for the management of CLZ-induced akathisia. The improved management of treatment-induced akathisia and other adverse events can extend the potential application of CLZ for treatment-resistant schizophrenia.
Study on Satellite Communications using Ultra Wideband (UWB) Signals
Kunisawa, Yoshio,Ishikawa, Hiroyasu,Iwai, Hisato,Shinonaga, Hideyuki 통신위성우주산업연구회 2003 Joint Conference on Satellite Communications Vol.2003 No.-
In this paper, the possibility of satellite communication systems using a multiband UWB signal format is considered. For terrestrial short-distance high-speed communications, multiband UWB schemes are proposed in IEE 802.15 TG3a and the discussion is ongoing at the standardization body. In the multiband UWB scheme, frequency hopping is adopted over 3.1-10.6 GHz, which is regulated by the FCC (Federal Communication Commission) of the U.S.A., and the bandwidth of one hopping spectrum (subband) is about 500 MHz. Multiband technology inherently has some suitable characteristics for terrestrial UWB such as applicability to variable transmission rates, avoidance of harmful interference to other systems, simple localizability of frequency allocations, and so forth. In this paper, a satellite communication downlink employing the multiband UWB signal transmission is considered. The total bandwidth is assumed to be 500 MHz in the allocation of the satellite downlink and it is divided into multiple subbands. We report the initial results of the study on the link budget calculation and the estimation of the signal transmission speed assuming multiband UWB signal transmission from a GSO satellite to the earth's surface.
Ramelteon for Delayed Sleep-wake Phase Disorder: A Case Report
Masahiro Takeshima,Tetsuo Shimizu,Hiroyasu Ishikawa,Takashi Kanbayashi 대한정신약물학회 2020 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.18 No.1
Recently developed melatonin receptor agonists are expected to be effective for delayed sleep-wake phase disorder (DSWPD). To date, however, no study has described the effect of melatonin receptor agonists on DSWPD. We report the case of a 15-year-old girl with DSWPD who was successfully treated with ramelteon 4 mg at 7 PM. DSWPD symptoms were resolved; her sleep-wake and biological rhythms were normalized.