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RISS 인기검색어
- 검색키워드
- 저자 : Hidehiro Kaneko (검색결과 4 건)
- 무료
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- 유료
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Tumor necrosis factor-α converting enzyme is a key mediator of abdominal aortic aneurysm development
Kaneko, Hidehiro,Anzai, Toshihisa,Horiuchi, Keisuke,Kohno, Takashi,Nagai, Toshiyuki,Anzai, Atsushi,Takahashi, Toshiyuki,Sasaki, Aya,Shimoda, Masayuki,Maekawa, Yuichiro,Shimizu, Hideyuki,Yoshikawa, Tsu Elsevier 2011 Atherosclerosis Vol.218 No.2
<P><B>Abstract</B></P><P><B>Objective</B></P><P>Tumor necrosis factor (TNF)-α is known to be elevated in plasma and the aorta in abdominal aortic aneurysm (AAA) patients. We sought to clarify the role of TNF-α converting enzyme (Tace), which cleaves the transmembrane precursor of TNF-α, in AAA development.</P><P><B>Methods</B></P><P>We obtained aortic sample of AAA during surgical operation to assess the histological features and protein expression of human AAA. AAA was induced in mice with temporal systemic deletion of Tace by the inducible Mx-1 Cre transgene (TaceMx1) and in wild-type littermates (CON) by periaortic application of CaCl<SUB>2</SUB> (AAA/TaceMx1, AAA/CON).</P><P><B>Results</B></P><P>Tace expression was increased in human AAA samples as compared with normal aorta. Six weeks postoperatively, aortic diameter in AAA/TaceMx1 was decreased than in AAA/CON in association with attenuated TNF-α expression and extracellular matrix disruption. Increased activities of matrix metalloproteinase (MMP)-9 and MMP-2, numbers of Mac-2-positive macrophages, CD3-positive T lymphocytes and CD31-positive vessels in periaortic tissues, mRNA expression of CD68, monocyte chemotactic protein-1, TNF-α, vascular endothelial growth factor-A, p47 and glutathione peroxidases, and protein expression of phospho-c-Jun N-terminal kinase in AAA were all attenuated by Tace deletion. Protein expression of transforming growth factor (TGF)-β1 was upregulated by Tace deletion in sham-operated mice. TGF-β1 expression was further increased in AAA/TaceMx1.</P><P><B>Conclusions</B></P><P>Tace was overexpressed in the aortic wall in human and experimental AAA. Temporal systemic deletion of Tace prevented AAA development in association with attenuating inflammation, oxidative stress, neoangiogenesis and extracellular matrix disruption, suggesting a crucial role of Tace in AAA development.</P>
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Effectiveness and Approach of Rehabilitation in Patients With Acute Heart Failure: A Review
Kensuke Ueno,Hidehiro Kaneko,Hidetaka Itoh,Norifumi Takeda,Hiroyuki Morita,Katsuhito Fujiu,Kentaro Kamiya,Issei Komuro 대한심장학회 2022 Korean Circulation Journal Vol.52 No.8
Acute heart failure is associated with high mortality and frequent rehospitalization, resulting in enormous healthcare costs and declining physical function, activities of daily living, and quality of life. Cardiac rehabilitation has been recommended as one of the non-pharmacologic treatments for patients with heart failure. However, much of the evidence for cardiac rehabilitation interventions reported to date has been limited to chronic heart failure. In recent years, the effectiveness of rehabilitation intervention in patients with acute heart failure has been reported, led by the Rehabilitation Therapy in Older Acute Heart Failure Patients (REHAB-HF) trial. This review overviews the recent evidence of rehabilitation in patients with acute heart failure.
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ZHAOHUI LUO,KEIKO KATAYAMA-HIRAYAMA,KIMIAKI HIRAYAMA,TETSUYA AKITSU,HIDEHIRO KANEKO 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2008 NANO Vol.3 No.5
Pyrene is a high molecular weight polycyclic aromatic hydrocarbon (PAH) that is found in water systems worldwide. It is harmful to living organisms, even when taken in very small amounts. The photocatalytic degradation of pyrene in porous Pt/TiO₂–SiO₂ photocatalyst (PPtPC) suspension under UV irradiation was investigated in this study. PPtPC was prepared by a simple heat treatment of the compacted powder mixtures of anatase TiO₂ and amorphous SiO₂ with camphor as a pore directing template, followed by coating platinum by the dip-coating method. X-ray diffraction (XRD), scanning electron microscopy (SEM) with an integrated energy-dispersive analysis of the X-ray (EDX) system, and Brunauer–Emmett–Teller (BET) were used to characterize PPtPC. The degradation kinetics of pyrene in different experimental conditions, such as initial concentration of pyrene, oxygen concentrations, pH, and temperature, were investigated. The durability of PPtPC was also tested. The results indicate that the structure of TiO₂ in PPtPC is anatase. The aggregated size of PPtPC is in the range of 10–100 μm, the mean pore diameter is 3 nm, and the BET surface area is 109 m² g-¹. The photocatalytic degradation process of pyrene follows pseudo-first-order kinetics. The rate constants increase as the initial concentration of pyrene and pH decrease. Higher temperature slightly enhances the rate constant. The dissolved oxygen in the photocatalytic degradation process is not as important as in the photolysis process. The recovered PPtPC still shows high photoactivity. This work suggests that PPtPC offers a promising method for high molecular weight PAH removal.
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배영진,카네코 히데히로,후지타 켄지,Bae, Young Jin,Kaneko, Hidehiro,Fujita, Kenji 유기성자원학회 1993 유기물자원화 Vol.1 No.1
퇴비화반응(堆肥化反應)의 주체가 되는 미생물(微生物)이 퇴비화반응(堆肥化反應)에 어떻게 관여하는 가에 대해 충분히 안다는 것은 퇴비화처리(堆肥化處理) 기술상(技術上) 중요한 점이라 할 수 있다. 본(本) 연구(硏究)에서는 우선, 퇴비화실험(堆肥化實驗)을 하면서 실험과정(實驗過程)에서 나타나는 각종 미생물상(微生物相)의 수적(數的) 변화(變化)를 추적했다. 그 결과 세균(細菌)과 방선균(放線菌)이 반응(反應)의 중심이 되어 있는 것을 알았다. 그러나, 그 수(數)는 반응효과(反應效果)와 무관(無關)하다라는 것이 나타나, 미생물(微生物)의 활성지표(活性指標)가 필요하다는 것이 지적되었다. 따라서, 새로운 증식활성도(增殖活性度)라는 지표(指標)를 도입하여, 이 지표(指標)와 퇴비화반응(堆肥化反應)의 중요한 환경인자중(環境因子中)의 하나인 pH와의 관계(關係) 및 반응물(反應物)의 안정도(安定度)와의 관계(關係)에 대해 검토하였다. 그 결과(結果), 증식활성도(增殖活性度)는 퇴비화반응(堆肥化反應)의 효율(效率) 및 안정도(安定度)의 지표(指標)가 될 수 있다는 것이 나타났다. Change in microbial numbers during experimental composting has been investigated. The results show that bacteria and actinomycetes play an important role in decomposing the composting material. The number of bacteria has no relation to the efficiency of composting, though it greatly correlates to the decomposition ratio. Bacterial growth activity that shows potential of bacterial growth was originally proposed. The influence of pH and the decomposition ratio on the growth activity has been studied. It was clarified that the bacterial growth activity is useful in evaluating the efficiency of composting and the maturity of produced compost.
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