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Genomic Profiling of Prostate Cancer: An Updated Review
Hatano Koji,Nonomura Norio 대한남성과학회 2022 The World Journal of Men's Health Vol.40 No.3
Understanding the genomic profiling of prostate cancer is crucial, owing to the emergence of precision medicine to guide therapeutic approaches. Over the last decade, integrative genomic profiling of prostate tumors has provided insights that improve the understanding and treatment of the disease. Minimally invasive liquid biopsy procedures have emerged to investigate cancer-related molecules with the advantage of detecting heterogeneity as well as acquired resistance in cancer. The metastatic castration-resistant prostate cancer (mCRPC) tumors have a highly complex genomic landscape compared to primary prostate tumors; a number of mCRPC harbor clinically actionable molecular alterations, including DNA damage repair (e.g., BRCA1/2 and ATM) and PTEN/phosphoinositide 3-kinase signaling. Heterogeneity in the genomic landscape of prostate cancer has become apparent and genomic alterations of TP53, RB1, AR, and cell cycle pathway are associated with poor clinical outcomes in patients. Prostate cancer with mutant SPOP shows a distinct pattern of genomic alterations, associating with better clinical outcomes. Several genomic profiling tests, which can be used in the clinic, are approved by the U.S. Food and Drug Administration, including MSK-IMPACT, FoundationOne CDx, and FoundationOne Liquid CDx. Here, we review emerging evidence for genomic profiling of prostate cancer, especially focusing on associations between genomic alteration and clinical outcome, liquid biopsy, and actionable molecular alterations.
Study of Cavitation Instabilities in Double-Suction Centrifugal Pump
Hatano, Shinya,Kang, Donghyuk,Kagawa, Shusaku,Nohmi, Motohiko,Yokota, Kazuhiko Korean Society for Fluid machinery 2014 International journal of fluid machinery and syste Vol.7 No.3
In double-suction centrifugal pumps, it was found that cavitation instabilities occur with vibration and a periodic chugging noise. The present study attempts to identify cavitation instabilities in the double-suction centrifugal pump by the experiment and Computational Fluid Dynamics (CFD). Cavitation instabilities in the tested pump were classified into three types of instabilities. The first one, in a range of cavitation number higher than breakdown cavitation number, is cavitation surge with a violent pressure oscillation. The second one, in a range of cavitation number higher than the cavitation number of cavitation surge, is considered to be rotating cavitation and causes the pressure oscillation due to the interaction of rotating cavitation with the impeller. Last one, in a range of cavitation number higher than the cavitation number of rotating cavitation, is considered to be a surge type instability.
Hatano, Atsushi,Inoue, Kazuhito,Deo, Daisuke,Sakurai, Hidehiro Korean Society of Photoscience 2002 Journal of Photosciences Vol.9 No.2
Two ferredoxin (Fd) fractions, namely, Fd-A and Fd-B were isolated from Heliobacillus mobilis cells, and purified by ammonium sulfate fractionation, DEAE, gel-permeation and Phenyl-Superose column chromatographies under anaerobic conditions. Their absorption spectra were typical of 2[4Fe-4S] cluster type Fds with peaks at about 385 and 280 nm and a shoulder at about 305 nm. Their N-terminal amino acid sequences were determined, which showed that both of them contain a [4Fe-4S] cluster binding motif. Fd-B was sensitive to oxygen, and itsA$_{385}$ value decreased by about 50% in 2 h at 4$^{\circ}C$ under aerobic conditions. In contrast, $A_{385}$ of Fd-A was essentially unchanged up to 24 h under the same conditions.
Masakazu Hatano,Hiroyuki Kamei,Azusa Kato,Ippei Takeuchi,Manako Hanya,Junji Uno,Shigeki Yamada,Kiyoshi Fujita,Nakao Iwata 대한정신약물학회 2017 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.15 No.2
Objective: The adverse effects of antipsychotic agents can have a marked influence on medication adherence. In this study, we investigated the adverse events of antipsychotics that are less likely to be reported by patients and the reasons why such symptoms remain latent. Methods: Data were collected by interviewing patients using a subjective questionnaire, and the associations between unreported symptoms and background factors were investigated. Results: A total of 306 patients with schizophrenia or schizoaffective disorder were examined. Their major symptoms were daytime sleepiness (50.0%), weight gain (42.2%), and sexual dysfunction (38.9%). Sexual dysfunction was nominal significantly more common among the patients that had been treated with antipsychotic agent polypharmacy (odds ratio [OR], 2.14; 95% confidence interval [CI], 1.07 to 4.30), and was nominal significantly more common among outpatients (OR, 1.78; 95% CI, 1.02 to 3.13). Only approximately 30% of the patients had reported their symptoms to their physicians. Conclusion: Patients receiving antipsychotic treatment tolerate some symptoms and do not feel able to report them to their physicians. The most common reason for this is an insufficient patient-physician relationship. Sexual dysfunction is especially hard to identify because it is a delicate problem, and our findings demonstrate that subjective questionnaires are helpful for detecting such symptoms.
Classification of Osteoporosis from Phalanges CR Images Based on DCNN
Kazuhiro HATANO,Seiichi MURAKAMI,Huimin LU,Joo Kooi TAN,Hyoungseop KIM,Takatoshi AOKI 제어로봇시스템학회 2017 제어로봇시스템학회 국제학술대회 논문집 Vol.2017 No.10
Osteoporosis is known as a disease of bone. Visual screening using Computed Radiography (CR) images is an effective method for osteoporosis, however, there are many similar diseases that exhibit state of low bone mass. In this paper, we propose an automatic identification method of osteoporosis from phalanges CR images. In the proposed method, we implement a classifier based on Deep Convolutional Neural Network (DCNN), and identify unknown CR images as normal or abnormal. For training and evaluating of CNN, we use pseudo color images. In the experiment, we apply our proposal method to 101 cases and TPR of 64.7 [%] and FPR of 6.51 [%] were obtained.
Skin Barrier Abnormalities in Atopic Dermatitis: Cross Talk with Allergic Inflammation
( Yutaka Hatano ) 한국피부장벽학회 2012 한국피부장벽학회지 Vol.14 No.2
The skin barrier function is totally disturbed in atopic dermatitis (AD). Regarding permeability barrier dysfunction, a significant incidence of genetic abnormality in filaggrin in patients with AD is one of the pivotal discoveries, which is stimulating studies on aspects of barrier dysfunction in AD. Currently, permeability barrier homeostasis is one of the most important issues, not only in cutaneous biology, but also in allergology and immunology. Permeability barrier abrogation not only induces cutaneous inflammation, but is also involved in the induction of Th2 type immunological reactions. Conversely, Th2 or other cytokines abrogate permeability barrier homeostasis. In addition to these "Outside to Inside" and "Inside to Outside" relationships between permeability barrier abrogation and allergic inflammation, a new concept called "Intrinsic" cross talk, is proposed in this review. In the "Intrinsic" cross talk" alteration of one macromolecule in keratinocytes affects permeability barrier homeostasis and, simultaneously, induces or augments inflammation.
Masakazu Hatano,Hiroyuki Kamei,Risa Inagaki,Haruna Matsuzaki,Manako Hanya,Shigeki Yamada,Nakao Iwata 대한정신약물학회 2018 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.16 No.2
Objective: Suvorexant is a novel hypnotic drug that does not interact with the conventional γ-aminobutyric acid (GABA)-A receptor. We investigated the method by which suvorexant was introduced in insomnia patients who were taking benzodiazepine receptor agonists (BzRA). Methods: This was a retrospective study. We extracted clinical data for patients who were prescribed suvorexant and were already using BzRA. The patients were assigned to two groups, the switching and add-on groups. We assessed the suvorexant discontinuation rate at one month after the prescription of the drug. Results: One hundred and nineteen patients were assigned to the switching group, and 109 were assigned to the add-on group. The add-on group exhibited a significantly higher all-cause discontinuation rate than the switching group (odds ratio, 2.7; 95% confidence interval, 1.5 to 5.0; adjusted p<0.001). Intolerability was a significantly stronger risk factor for suvorexant discontinuation in the add-on group (22.0% vs. 7.6%, p<0.002), and the most common adverse effect was oversedation. Conclusion: Our results show that the add-on of suvorexant increases the frequency of oversedation compared with switching in insomnia patients that are taking BzRA. However, this was only a preliminary retrospective study, and further studies will be required to confirm our findings.