http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : Hao Xiaobin (검색결과 6 건)
- 무료
- 기관 내 무료
- 유료
-
Wu Hao,Wei Guoli,Luo Lixia,Li Lingchang,Gao Yibo,Tan Xiaobin,Wang Sen,Chang Haoxiao,Liu Yuxi,Wei Yingjie,Song Jie,Zhang Zhenhai,Huo Jiege 한국생체재료학회 2023 생체재료학회지 Vol.27 No.00
Combination of chemotherapy and immune checkpoint inhibitor therapy has greatly improved the anticancer effect on multiple malignancies. However, the efficiency on triple-negative breast cancer (TNBC) is limited, since most patients bear “cold” tumors with low tumor immunogenicity. Doxorubicin (DOX), one of the most effective chemotherapy agents, can induce immunogenic cell death (ICD) and thus initiating immune response.In this study, to maximize the ICD effect induced by DOX, chitosan and cell-penetrating peptide (R6F3)-modified nanoparticles (PNPs) loaded with ginsenoside Rg3 (Rg3) were fabricated using the self-assembly technique, followed by co-encapsulation with DOX based on thermo-sensitive hydrogel. Orthotopic tumor model and contralateral tumor model were established to observe the antitumor efficacy of the thermo-sensitive hydrogel combined with anti-PD-L1 immunotherapy, besides, the biocompatibility was also evaluated by histopathological.Rg3-PNPs strengthened the immunogenic cell death (ICD) effect induced by DOX. Moreover, the hydrogel co-loading Rg3-PNPs and DOX provoked stronger immune response in originally nonimmunogenic 4T1 tumors than DOX monotherapy. Following combination with PD-L1 blocking, substantial antitumor effect was achieved due to the recruitment of memory T cells and the decline of adaptive PD-L1 enrichment.The hydrogel encapsulating DOX and highly permeable Rg3-PNPs provided an efficient strategy for remodeling immunosuppressive tumor microenvironment and converting immune “cold” 4T1 into “hot” tumors.
-
Preparation and Properties of the Fast-Curing γ-Ray-Shielding Materials Based on Polyurethane
Minxuan Ni,Xiaobin Tang,Hao Chai,Yun Zhang,Tuo Chen,Da Chen 한국원자력학회 2016 Nuclear Engineering and Technology Vol.48 No.6
In this study, fast-curing shielding materials were prepared with a two-component polyurethane matrix and a filler material of PbO through a one-step, laboratory-scale method. With an increase in the filler content, viscosity increased. However, the two components showed a small difference. Curing time decreased as the filler content increased. The minimum tack-free time of 27 s was obtained at a filler content of 70 wt%. Tensile strength and compressive strength initially increased and then decreased as the filler content increased. Even when the filler content reached 60 wt%, mechanical properties were still greater than those of the matrix. Cohesional strength decreased as the filler content increased. However, cohesional strength was still greater than 100 kPa at a filler content of 60 wt%. The γ-ray-shielding properties increased with the increase in the filler content, and composite thickness could be increased to improve the shielding performance when the energy of γ-rays was high. When the filler content was 60 wt%, the composite showed excellent comprehensive properties.
-
Background Error Statistics for Aerosol Variables from WRF/Chem Predictions in Southern California
Zengliang Zang,Zilong Hao,Xiaobin Pan,Zhijin Li,Dan Chen,Li Zhang,Qinbin Li 한국기상학회 2015 Asia-Pacific Journal of Atmospheric Sciences Vol.51 No.2
Background error covariance (BEC) is crucial in data assimilation. This paper addresses the multivariate BEC associated with black carbon, organic carbon, nitrates, sulfates, and other constituents of aerosol species. These aerosol species are modeled and predicted using the Model for Simulating Aerosol Interactions and Chemistry scheme (MOSAIC) in the Weather Research and Forecasting/Chemistry (WRF/Chem) model at a resolution of 4 km in Southern California. The BEC is estimated from the differences between the 36-hour and 12-hour forecasts using the NMC method. The results indicated that the maximum background error standard deviation is associated with nitrate and is larger than that of black carbon, organic carbon, and sulfate. The horizontal and vertical scale of the correlation of nitrate is much smaller than that of other species. A significant cross-correlation is found between the species of black carbon and organic carbon. The cross-correlations between nitrate and other variables are relatively smaller and exhibit a relatively smaller length scale. Single observation data assimilation experiments are performed to illustrate the effect of the BEC on analysis increments.
-
Pin Gong,Minxuan Ni,Hao Chai,Feida Chen,Xiaobin Tang 한국원자력학회 2018 Nuclear Engineering and Technology Vol.50 No.3
With a highly functional methyl vinyl silicone rubber (VMQ) matrix and filler materials of B4C, PbO, andbenzophenone (BP) and through powder surface modification, silicone rubber mixing, and vulcanizedmolding, a flexible radiation shielding and resistant composite was prepared in the study. The dispersionproperty of the powder in the matrix filler was improved by powder surface modification. BP was addedinto the matrix to enhance the radiation resistance performance of the composites. After irradiation, thetensile strength, elongation, and tear strength of the composites decreased, while the Shore hardness ofthe composites and the crosslinking density of the VMQ matrix increased. Moreover, the compositeswith BP showed better mechanical properties and smaller crosslinking density than those without BPafter irradiation. The initial degradation temperatures of the composites containing BP before and afterirradiation were 323.6 C and 335.3 C, respectively. The transmission of neutrons for a 2-mm thicksample was only 0.12 for an AmeBe neutron source. The transmission of g-rays with energies of 0.662,1.173, and 1.332 MeV for 2-cm thick samples were 0.7, 0.782, and 0.795, respectively
-
Bias process for heteroepitaxial diamond nucleation on Ir substrates
Wang Weihua,Yang Shilin,Liu Benjian,Hao Xiaobin,Han Jiecai,Dai Bing,Zhu Jiaqi 한국탄소학회 2023 Carbon Letters Vol.33 No.2
Heteroepitaxy is a better method of enlarging SCD wafer size than homoepitaxy. In this work, several aspects of the bias process for heteroepitaxial diamond nucleation are studied experimentally. First, with increasing bias time, the diamond-nucleation pathway is found to transform from “isolated-crystal nucleation” to “typical domain-nucleation” and back to “isolated-crystal nucleation.” An interdependent relationship between bias voltage and bias time is proposed: the higher the bias voltage, the shorter the bias time. Second, a correlation exists between the threshold bias voltage and reactor-chamber pressure: a higher reactor chamber pressure usually requires a higher threshold bias voltage to realize “typical domain nucleation.” Third, diamond bias-enhanced nucleation and growth is observed at a high CH4 content, where the dynamic equilibrium between amorphous-carbon-layer deposition and atomic-hydrogen etching is broken. Finally, epitaxial nucleation is obtained on a substrate with ∅30 mm in a home-made MPCVD setup.
-
Adjustable wavelength and lifetime in Mn4+ ion doped phosphate glasses
Chengguo Ming,Hanxiong Liu,Feng Song,Xiaobin Ren,Liqun An,Yanming Hao,Gangzhi Wang 한국물리학회 2013 Current Applied Physics Vol.13 No.6
Phosphate glasses doped with Mn4þ ion were prepared using high temperature melting method. Under 408 nm excitation, the peak wavelength and lifetime of the fluorescence are related to the Mn4þ ion concentration. With the increasing of Mn4þ ion concentration, the fluorescence wavelength varies from 605 nm to 685 nm and the lifetime increases from several microseconds to one millisecond. The fluorescence wavelength is variable and the lifetime is tunable for our materials.
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
