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Haifeng Yang,Rui Deng,Junwei Jin,Yuling Wu,Xin Jiang,Jinhua Shi 대한환경공학회 2022 Environmental Engineering Research Vol.27 No.4
Hydrolytic performances of different organic compounds in lignocellulosic biomass (LB) during anaerobic digestion (AD) are worth investigating due to the complex and refractory structure of lignocellulose. This study aimed to clarify the hydrolytic performances of different lignocellulosic components (hemicellulose, cellulose and lignin) and other typical organics (saccharides, protein and lipid) in AD process. Furthermore, an in-depth study of different lignocellulosic components mono-/co-digestive performances, as well as their effects on digestive systems were also designed to explain the mechanism. Kinetic models were specially applied to evaluate the hydrolytic process and make comparison among different lignocellulosic components. Results showed that hemicellulose obtained high degradation ratio (77.2-85.0%) during anaerobic digestion, while cellulose was difficult to hydrolyze without sufficient acidity. And organics (saccharides, protein and lipid) were much easier to be hydrolyzed than lignocellulose. Results also depicted that lignocellulose addition could efficiently enhance the volatile solid (VS) removals of digestive systems, while lignin existing in systems reduced the VS removal. The limited hydrolysis of lignocellulose hindered the degradation of total VS in digester. It is quite important to obtain high bioenergy conversion, pretreatments, which can destroy the lignin wrapping in LBs digestion. This study could provide a reference for the AD of LBs.
Jian Wang,Qiong Niu,Ning Shi,Chengxia Liu,Haifeng Lian,Jiancheng Li,Kun Li,K. Li 대한독성 유전단백체 학회 2017 Molecular & cellular toxicology Vol.13 No.3
Drug resistance remains to be one of the major challenges in clinical treatment of gastric cancer (GC). Accumulating evidences have highlighted the involvement of long non-coding RNA (lncRNA) in carcinogenesis, chemoresistance, and metastasis. NEAT1, a recently identified lncRNA, was identified as an oncogene to regulate carcinogenesis. This present study aimed to investigate the role of NEAT1 in the drug resistance in GC. Our study found that NEAT1 expression was significantly upregulated in relapsed GC patients and cisplatin (CDDP)-resistant cell lines compared with primary GC patients and parental GC cell lines. NEAT1 upregulation was largely companied with the induction of P-gp. Overexpression of NEAT1 significantly increased the expression of several drug-resistance proteins, thereby compromising the sensitivity of GC cells to CDDP. In contrast, NEAT1 knockdown by RNAi did the opposite. Therefore, lncRNA NEAT1 is an important modulator for drug resistance of GC via promoting the expression of P-gp and other associated proteins.
Kang, Ping,Liu, Yulan,Zhu, Huiling,Zhang, Jing,Shi, Haifeng,Li, Shuang,Pi, Dinan,Leng, Weibo,Wang, Xiuying,Wu, Huanting,Hou, Yongqing Asian Australasian Association of Animal Productio 2018 Animal Bioscience Vol.31 No.4
Objective: This experiment was conducted to investigate whether asparagine (Asn) could improve liver energy status in weaning pigs when challenged with lipopolysaccharide. Methods: Forty-eight weaned pigs ($Duroc{\times}Large\;White{\times}Landrace$, $8.12{\pm}0.56kg$) were assigned to four treatments: i) CTRL, piglets received a control diet and injected with sterile 0.9% NaCl solution; ii) lipopolysaccharide challenged control (LPSCC), piglets received the same control diet and injected with Escherichia coli LPS; iii) lipopolysaccharide (LPS)+0.5% Asn, piglets received a 0.5% Asn diet and injected with LPS; and iv) LPS+1.0% Asn, piglets received a 1.0% Asn diet and injected with LPS. All piglets were fed the experimental diets for 19 d. On d 20, the pigs were injected intraperitoneally with Escherichia coli LPS at $100{\mu}g/kg$ body weights or the same volume of 0.9% NaCl solution based on the assigned treatments. Then the pigs were slaughtered at 4 h and 24 h after LPS or saline injection, and the liver samples were collected. Results: At 24 h after LPS challenge, dietary supplementation with 0.5% Asn increased ATP concentration (quadratic, p<0.05), and had a tendency to increase adenylate energy charges and reduce AMP/ATP ratio (quadratic, p<0.1) in liver. In addition, Asn increased the liver mRNA expression of pyruvate kinase, pyruvate dehydrogenase, citrate synthase, and isocitrate dehydrogenase ${\beta}$ (linear, p<0.05; quadratic, p<0.05), and had a tendency to increase the mRNA expression of hexokinase 2 (linear, p<0.1). Moreover, Asn increased liver phosphorylated AMP-activated protein kinase (pAMPK)/total AMP-activated protein kinase (tAMPK) ratio (linear, p<0.05; quadratic, p<0.05). However, at 4 h after LPS challenge, Asn supplementation had no effect on these parameters. Conclusion: The present study indicated that Asn could improve the energy metabolism in injured liver at the late stage of LPS challenge.