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RISS 인기검색어
- 검색키워드
- 저자 : Gupta Gourav (검색결과 3 건)
- 무료
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Modafinil Dependence and Hypersexuality: A Case Report and Review of the Evidence
Sahoo Swapnajeet,Subodh BN,Gupta Gourav 대한정신약물학회 2016 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.14 No.4
Apart from sleep wake disorders, nowadays, modafinil is being prescribed for several psychiatric disorders including depression. Despite being reported as to be having very low abuse potential, cases of modafinil dependence had come to the limelight. In this case report, we describe a 35 year old man with bipolar affective disorder while in remission who developed modafinil dependence and later on, had hypersexuality when he increased the dose of modafinil from 400 to 1,000 mg/day. Existing literature suggests that modafinil when taken above prescribed doses can cause many side effects ranging from nausea, vomiting to psychotic exacerbation and mania. However, hypersexuality as a side effect of modafinil overuse is not commonly seen. The exact pathophysiological mechanism of modafinil induced hypersexuality is not clear. Clinicians should be aware of possibility of modafinil leading to dependence and this rare significant side effect of modafinil.
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Punit Kumar Khanna,Arun Kumar,Nidhi Dogra,Heena Gupta,Gourav Gupta,Vijeshwar Verma,Ratna Chandra 한국작물학회 2014 Journal of crop science and biotechnology Vol.17 No.1
Genetic diversity among 14 Withania accessions were studied using morphological, chemical, and RAPD (Rapid Amplification ofPolymorphic DNA) markers. On the basis of morphological variation and maximum assimilation of chemical constituents, wild accessionswere considered elite as compared to cultivated. The molecular study showed that a total of 12 DNA fragments were amplifiedwith five random decamer primers 75% of which were polymorphic. Genetic similarity matrix based on the Dice index detected coefficientsranging from 0.556 to 0.941. These coefficients were used to construct a dendrogram using unweighted pair group method witharithmetic mean (UPGMA). These accessions were clustered into two major groups; the first group included AGB-009, AGB-012,AGB-042, AGB-030, AGB-053, AGB-019, AGB-017, AGB-002, and AGB-003; the second included AGB-025, AGB-001, AGB-036,AGB-015, and AGB-055. The highest similarity among the Ashwagandha accessions was observed between AGB-009 and AGB-030,AGB-009 and AGB-012, AGB-042 and AGB-030, AGB-025 and AGB-001, AGB-036 and AGB-015, AGB-015 and AGB-055 andbetween AGB-015 and AGB-055. The most distant populations in the dendrogram were AGB-053 and AGB-055. The combination ofmorphological, chemical, and molecular markers assessment will be useful in studying the genetic diversity of Withania for identification,conservation, breeding, improvement activities, and in order to achieve elite type in terms of bioactive metabolites
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Khanna, Punit Kumar,Chandra, Ratna,Kumar, Arun,Dogra, Nidhi,Gupta, Heena,Gupta, Gourav,Verma, Vijeshwar 한국작물학회 2014 Journal of crop science and biotechnology Vol.17 No.1
Genetic diversity among 14 Withania accessions were studied using morphological, chemical, and RAPD (Rapid Amplification of Polymorphic DNA) markers. On the basis of morphological variation and maximum assimilation of chemical constituents, wild accessions were considered elite as compared to cultivated. The molecular study showed that a total of 12 DNA fragments were amplified with five random decamer primers 75% of which were polymorphic. Genetic similarity matrix based on the Dice index detected coefficients ranging from 0.556 to 0.941. These coefficients were used to construct a dendrogram using unweighted pair group method with arithmetic mean (UPGMA). These accessions were clustered into two major groups; the first group included AGB-009, AGB-012, AGB-042, AGB-030, AGB-053, AGB-019, AGB-017, AGB-002, and AGB-003; the second included AGB-025, AGB-001, AGB-036, AGB-015, and AGB-055. The highest similarity among the Ashwagandha accessions was observed between AGB-009 and AGB-030, AGB-009 and AGB-012, AGB-042 and AGB-030, AGB-025 and AGB-001, AGB-036 and AGB-015, AGB-015 and AGB-055 and between AGB-015 and AGB-055. The most distant populations in the dendrogram were AGB-053 and AGB-055. The combination of morphological, chemical, and molecular markers assessment will be useful in studying the genetic diversity of Withania for identification, conservation, breeding, improvement activities, and in order to achieve elite type in terms of bioactive metabolites.
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