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Yonghua Cui,Yuxin Shu,Yuanyuan Zhu,Yonghui Shi,Guowei Le 한국식품영양과학회 2012 Journal of medicinal food Vol.15 No.8
High-fat diets (HFDs) have been found to influence central nervous system development and to cause cognitive impairments in human epidemiologic studies, as well as in animal investigations. These adverse effects on learning and memory induced by an HFD have been associated with an impaired hippocampus, including hippocampal oxidative damage. Previously, we had found that a-lipoic acid (a-LA) could ameliorate the oxidative stress in non-neural organs (liver, jejunum,and spleen) induced by a 10-week HFD (21.2% fat) food regimen in mice. In this study, we investigated whether a 10-week HFD (21.2% fat) induced oxidative stress in the hippocampus or impaired spatial learning in mice and whether LA ameliorated these effects. The HFD was found to induce oxidative stress (a decrease in catalase activity, glutathione peroxidase activity, and total antioxidative capacity and an increase in malondialdehyde levels) in the mouse hippocampus. In addition,we found that the HFD impaired spatial recognition memory of mice in the Y-maze paradigm. Furthermore, the hippocampal oxidative stress and impaired spatial recognition memory of the mice were reduced in HFD diets supplemented with 0.1% LA. These findings suggest that LA, as a strong antioxidant, may help prevent HFD-induced learning impairments by ameliorating associated oxidative stress in the hippocampus.
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The Utilization of Social Networking Service and Japanese Manga in Strategic User Generated Design
Anak Agung Gede Dharma,Hiroyuki Kumamoto,Shogo Kochi,Natsuki Kudo,Guowei Wei,Shu Chuan Chiu,Kiyoshi Tomimatsu 한국멀티미디어학회 2011 한국멀티미디어학회 국제학술대회 Vol.2011 No.-
In this research, we propose an online service which utilizes Social Networking Service (SNS) as the medium and Japanese cartoon (manga) as the communication method. The growth of SNS has created a new potential in marketing. While users communicate and interact via SNS, the list of their conversation which is called casual data can be used to determine their needs or aspirations. SNS can be very useful for product/service developers, especially when developing new ideas or simply evaluating the feasibility of their existing products/services. Furthermore, SNS provides a unique system that enables expressive and two-way communication between its users. Although several online services that utilize SNS and casual data have been provided, the purpose of those services is still unclear and ineffective. To solve those problems we propose an innovative way of utilizing SNS and casual data in designing consumer generated design. In our proposed system, users can directly contribute to the product/service development process in an interesting way. We designed an online service which allows users to posts manga that describes their original idea. While contributing to the product/service development, they can also benefit from expressing their hobbies and receiving feedbacks from other users.
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Lichen Zhang,Linlin Wang,Jingwei Cai,Ting Yang,Jianke Li,Guowei Shu 한국식품과학회 2024 Food Science and Biotechnology Vol.33 No.4
Consuming pomegranate juice (PJ) is beneficial for hypertensive regulation because of the phenolic compounds in PJ and their inhibitory activity on angiotensin-I-converting enzyme (ACE). To better utilize bioactive function of food, microorganism fermentation has been adopted to alter phenolic metabolism. This study confirms that even under in vitro digestion, fermented PJ (FPJ) maintains higher ACE inhibitory activity than that of PJ. The main phenolic compounds in PJ were compared either under fermentation or in vitro digestion. This study finds that fermentation promotes antioxidant capacity of PJ. The chemical properties of FPJ are evaluated and the corresponding relationship with bioactivities is analyzed. A sensory evaluation comparison is conducted between FPJ and PJ, furnishing interesting information for consumers. This study highlights the relationship between ACE inhibitory activity of PJ and phenolic composition under fermentation and in vitro digestion, providing novel insights for diet regulation of phenolic-rich FPJ in ACE inhibition therapy.
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