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- 저자 : Guoqi Wang (검색결과 4 건)
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Zhaoxia Wang,Zhenxing Zhang,Yanling Guo,Huifeng Shui,Guoqi Liu,Tianbo Jin,Huijie Wang 한국유방암학회 2018 Journal of breast cancer Vol.21 No.4
Purpose: The aim of this study was to investigate the association of telomere length with breast cancer risk. We simultaneously explored the association between telomerase reverse transcriptase gene polymorphisms and telomere length. Methods: We used real-time quantitative polymerase chain reaction to measure relative telomere length (RTL) in genomic DNA extracted from peripheral blood from 183 breast cancer cases and 191 healthy controls. Genotyping was performed using the Sequenom MassARRAY platform. Results: Our results show that breast cancer patients had significantly shorter RTLs than control subjects (p< 0.05). When the RTLs were categorized into tertiles, we found that the lowest RTL was significantly associated with increased breast cancer risk compared with the highest RTL (odds ratio [OR], 2.33; 95% confidence interval [CI], 1.40–3.90; p=0.001). Subgroup analyses indicated that risk of breast cancer was also significantly increased in the lowest RTL compared with the highest RTL in age >40 years (OR, 2.41; 95% CI, 1.31–4.43; p=0.005), body mass index ≤24 kg/m2 (OR, 2.81; 95% CI, 1.55–5.10; p=0.001), and postmenopausal women (OR, 3.94; 95% CI, 1.63–9.51; p=0.002), respectively. In addition, individuals with the AA genotype of rs2853677 have longer telomeres than those of breast cancer patients with the AG genotype (p= 0.011). Conclusion: Our results suggest that shorter RTL was associated with an increased risk of breast cancer. An association was found between the AA genotype of rs2853677 and longer RTLs in the case group. Functional studies are warranted to validate this association and further investigate our findings.
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Set-membership Estimation for Event-triggered 2-D Systems Based on Zonotopes
Xudong Wang,Guoqi Wang,Liu Yang,Jitao Li 제어·로봇·시스템학회 2024 International Journal of Control, Automation, and Vol.22 No.3
This article discusses the interval estimation for 2-D systems in Roesser model with amplitude-boundedenvironmental disturbance and measurement noise. To save the limited capacity of communication network, anevent-triggered communication strategy is adopted to reduce the amount of packets transmitted through the network. Considering the amplitude-bounded uncertainties, an observer design criterion with peak-to-peak norm boundis deduced to suppress the influence of uncertainties on estimation error. A zonotope-based interval estimation approach is derived such that the actual state of 2-D Roesser system is enclosed within the estimated intervals on thebasis of the obtained observer. Finally, a numerical example is presented to verify the effectiveness of the proposedalgorithm
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Terminal sliding mode control of master-slave system with Markovian jump parameters
Xinghua Liu,Guoqi Ma,Hongsheng Xi,Weidong Wang 제어로봇시스템학회 2015 제어로봇시스템학회 국제학술대회 논문집 Vol.2015 No.10
The finite-time synchronization of master-slave system with Markovian jump parameters is investigated in this paper. An equivalent control based terminal sliding mode control is proposed to guarantee the finite-time convergence of error dynamics. By using stochastic theory and Lyapunov method, some conditions are proposed to facilitate the sliding surface design. Furthermore, a desired controller is synthesized to ensure that the trajectory of the closed-loop error system can be driven onto the prescribed sliding mode surface. Finally numerical simulations are presented to illustrate the effectiveness of terminal sliding mode control scheme.
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Kaiqiang Yu,Li Peng,Wenyu Liang,Jing Shi,Guoqi Zheng,Hong Wang,Xinhua Liang,Shijie Wu 한국식품과학회 2024 Food Science and Biotechnology Vol.33 No.1
Licorice from Glycyrrhiza uralensis roots is used in foods and medicines. Although we are aware that licorice roots and leaves have distinct material compositions, the specific reasons for these differences remain unknown. Comparison of the metabolomes and transcriptomes between the leaves and roots revealed flavonoids and triterpenoid saponins were significantly different. Isoflavones were enriched in roots because of upregulation of genes encoding chalcone isomerase and flavone synthase, which are involved in isoflavone synthesis. Six triterpenoid saponins were significantly enriched only in the roots. The leaves did not accumulate glycyrrhetinic acid because of low expression levels of genes involved in its synthesis. A gene encoding a UDP glycosyltransferase, which likely catalyzes the key step in the transformation of glycyrrhetinic acid to glycyrrhizin, was screened. Our results provide information about the differences in flavonoid and triterpenoid synthesis between roots and leaves, and highlight targets for genetic engineering.
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