Decellularized Matrices for the Treatment of Tissue Defects: from Matrix Origin to Immunological Mechanisms

Wang Xinyue,Guo Jiqiang,Yu Qing,Zhao Luyao,Gao Xiang,Wang Li,Wen Meiling,Yan Junrong,An Meiwen,Liu Yang 한국응용약물학회 2024 Biomolecules & Therapeutics(구 응용약물학회지) Vol.32 No.5

Decellularized matrix transplantation has emerged as a promising therapeutic approach for repairing tissue defects, with numerous studies assessing its safety and efficacy in both animal models and clinical settings. The host immune response elicited by decellularized matrix grafts of natural biological origin plays a crucial role in determining the success of tissue repair, influenced by matrix heterogeneity and the inflammatory microenvironment of the wound. However, the specific immunologic mechanisms underlying the interaction between decellularized matrix grafts and the host immune system remain elusive. This article reviews the sources of decellularized matrices, available decellularization techniques, and residual immunogenic components. It focuses on the host immune response following decellularized matrix transplantation, with emphasis on the key mechanisms of Toll-like receptor, T-cell receptor, and TGF-β/SMAD signaling in the stages of post-transplantation immunorecognition, immunomodulation, and tissue repair, respectively. Furthermore, it highlights the innovative roles of TLR10 and miR-29a-3p in improving transplantation outcomes. An in-depth understanding of the molecular mechanisms underlying the host immune response after decellularized matrix transplantation provides new directions for the repair of tissue defects.

Business Blogging e-Hub: An Innovative Approach to e-Business

Guo-An Wang 중앙대학교 한국전자무역연구소 2004 전자무역연구 Vol.2 No.-

With the rapid development of the Internet, e-business has been entering a new phase. However, there’re still some problems to be settled and needs for breakthrough. The paper proposes an innovative approach to e-business models with the aim of resolving the problems. The paper reviews the exiting e-commerce models and points out some of the common weaknesses of the models, and presents the "Business Blogging e-Hub" model for e-business. With the characteristics of all-sided information, multi-dimensional interactivity and trans-model e-commerce platform, the proposed model is created and derived from the integration of the "classical" e-commerce models as B2B, B2C and C2C with the technology and essence of blogging, and is thus sure to meet rapidly changing business needs.

On E-Commerce Development in Mainland China

Guo-an Wang,Yong T. Lim 국제e-비즈니스학회 2005 e-비즈니스 연구 Vol.6 No.3

Business Blogging e-Hub:An Innovative Approach to e-Business

Wang, Guo-An Korea Association for International Commerce and I 2005 통상정보연구 Vol.7 No.4

With the rapid development of the Internet, e-business has been entering a new phase. However, there're still some problems to be settled and needs for breakthrough. The paper proposes an innovative approach to e-business models with the aim to resolve the problems. The paper reviews the exiting e-commerce models and points out some of the common weaknesses of the models, and presents the "Business Blogging e-Hub"model for e-business. With the characteristics of all-sided information, multi-dimensional interactivity and trans-model e-commerce platform, the proposed model is created and derived from the integration of the "classical"e-commerce models as B2B, B2C and C2C with the technology and essence of blogging, and is thus sure to meet rapidly changing business needs.

Piracy of China's Trade Marks and Domain Names and Cultivation of its Famous Brands

Wang, Guo-an 한국통상정보학회 2004 통상정보연구 Vol.6 No.2

A large number of Chinese trade marks and domain names have been registered improperly or illegally by foreign companies or businessmen. Additionally, a large number of famous Chinese brands have vanished through joint ventures, mergers and acquisitions since foreign direct investment (FDI) came to China more than two decades ago because some Chinese managers have not been fully aware of the value of trade marks and domain names. Consequently, the number of China's registered trade marks and famous brands does not match China's export volume and its Number four trade status in the world. China's enterprises have yet to realize the effects of these events. It is very important for China to protect and cultivate its own famous brands. This paper discusses Chinese companies' neglect of the value of their trade marks and domain names, and the possible consequences. Additionally, this paper puts forward suggestions concerning the protection and cultivation of China's famous brands.

中國の WTO 加盟による日中經濟關係に與える影響

Wang Guo An 한국상품학회 2004 商品學硏究 Vol.- No.31

Since China was admitted to the World Trade Organization (WTO) on December 11, 2001, China has sped up its active participation in the competition of the world economy by lifting its trade andinvestment restrictions and limits. Its trading system is getting more and more free and its huge market with a population of 1.3 billion has been getting more and more open. With China's WTO accession. China has been honoring its commitments to its WTO members by complying with international business practices and WTO rules. For example, it will cut down its import tariffs for automobiles from the present 80% to 25% by 2006. Its financial sector and service industries are open to foreign investors now. As China's biggest business partner, Japan has benefited tremendously from China's open policies and deepening economic reform. In order to reduce the costs of production, a large number of enterprises from Japan have set up production bases in China since a Chinese worker's wages accounts for only one tenth of those of a Japanese worker on the average. Japan has become one of China's biggest investors on a par with the United States of America (USA). How are the Japanese enterprises in Japan and in China adjusting themselves to the rapid changes of the Chinese market? What characteristics do the Japanese enterprises in China have? What effects has China's WTO accession had on those Japanese enterprises that have invested in China? This paper finds answers to the above questions. It at first reviews the Sino-Japanese economic and trade relations since 1980s. then analyses the situation and characteristics of Japanese-invested enterprises in China, and explores their problems in China. Finally it puts forward some suggestions for the Japanese enterprises in China.

On China's Intellectual Property Rights Protection Online

Wang, Guo-an,Lim, Yong-taek 한국통상정보학회 2004 통상정보연구 Vol.6 No.1

Online people conduct all kinds of business activities, such as promoting the sales of products and services, reading newspapers, watching TV and movies, and sending business messages by e-mail, by e-voice and by a-fax. Computers with access to the Internet are defined by the United Nations as the fourth media characterized by instantaneousness, openness, limitlessness, boundlessness and globalization. With the development and popularization of the Internet and the advance of the information technology in China, Intellectual Property Rights (IPRs) violations online have frequently occurred in e-business activities. IPRs protection online has posed a great challenge not only for business managers and officials, but also for judges and lawyers because the rapid development of the Internet has created a legal vacuum governed by no laws in IPRs violation and protection online in China. The paper at first classifies IPRs into several categories, then reveals China's serious problems and challenges of IPRs violations online and stresses the necessity of China's IPRs protection online. Finally it puts forward some suggestions concerning IPRs protection online.

Piracy of China’s Trade Marks and Domain Names and Cultivation of its Famous Brands

Guo-an Wang 한국통상정보학회 2004 통상정보연구 Vol.6 No.2

A large number of Chinese trade marks and domain names have been registered improperly or illegally by foreign companies or businessmen. Additionally, a large number of famous Chinese brands have vanished through joint ventures, mergers and acquisitions since foreign direct investment (FDI) came to China more than two decades ago because some Chinese managers have not been fully aware of the value of trade marks and domain names. Consequently, the number of China’s registered trade marks and famous brands does not match China’s export volume and its No. four trade status in the world. China’s enterprises have yet to realize the effects of these events. It is very important for China to protect and cultivate its own famous brands. This paper discusses Chinese companies’ neglect of the value of their trade marks and domain names, and the possible consequences. Additionally, this paper puts forward suggestions concerning the protection and cultivation of China’s famous brands.

On China’s Intellectual Property Rights Protection Online

Guo-an WANG,Yong-taek LIM 한국통상정보학회 2004 통상정보연구 Vol.6 No.1

Online people conduct all kinds of business activities, such as promoting the sales of products and services, reading newspapers, watching TV and movies, and sending business messages by e-mail, by e-voice and by e-fax. Computers with access to the Internet are defined by the United Nations as the fourth media characterized by instantaneousness, openness, limitlessness, boundlessness and globalization. With the development and popularization of the Internet and the advance of the information technology in China, Intellectual Property Rights (IPRs) violations online have frequently occurred in e-business activities. IPRs protection online has posed a great challenge not only for business managers and officials, but also for judges and lawyers because the rapid development of the Internet has created a legal vacuum governed by no laws in IPRs violation and protection online in China.. The paper at first classifies IPRs into several categories, then reveals China’s serious problems and challenges of IPRs violations online and stresses the necessity of China’s IPRs protection online. Finally it puts forward some suggestions concerning IPRs protection online.

On the Development of Alibaba.com

Guo-an Wang 한국통상정보학회 2002 통상정보연구 Vol.4 No.2

Alibaba.com has developed very fast and created a miracle in the international e-business community since it was established just three years ago. The paper at first introduces its rapid development from its establishment, the construction of its websites and its e-products and eservices, its mode of operation and corporate culture. Secondly it analyses the reasons why it has not only survived, but also developed very fast and begun to make profits despite the cut-throat competition in the e-business community in the tough e-environment in China. Then it displays and analyzes its competitive edges and the challenges it is confronted with. Finally it predicts its promising future.