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Zeying Chu,Guanqun Ma,Xiangjun Sun,Zhihan Xu,Jianhua Zhang 한국식품영양과학회 2020 Journal of medicinal food Vol.23 No.5
Aging can cause retinal degeneration, which leads to visual impairment among the elderly population. Age-dependent increases in amyloid beta (Aβ) inducesinflammatory cytokine overexpression in the retinal pigment epithelium (RPE), which promotes the progression of age-related retinal degeneration. However, whether dietary antioxidants are useful for the treatment of RPE degeneration remains to be clarified. This study exposited the protective activities and underlying mechanisms of grape seed extracts (GSEs) against Aβ-induced proinflammatory events in mouse retinas and ARPE-19 cells. The experimental data demonstrated that GSEs attenuated the increases in messenger RNA (mRNA) levels of interleukin 12 (IL-12), interleukin 6 (IL-6), interleukin 1β (IL-1β), and interleukin 18 (IL-18) in the retinal tissues of Aβ-treated mice. The experimental results in mice were confirmed by findings in ARPE-19 cells with or without treatment with GSEs. GSEs affected the protein expression levels of endoplasmic reticulum stress markers in ARPE-19 cells exposed to Aβ. Knockdown of Bip blocked the inhibitory activities of GSEs on mRNA levels of IL-6, IL-1β, IL-18, and IL-8. We conclude that GSEs may suppress proinflammatory cytokines partly by increasing the expression of Bip.
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Teng Zhang,Xubo Ma,Kui Hu,GuanQun Jia Korean Nuclear Society 2024 Nuclear Engineering and Technology Vol.56 No.4
To accurately calculate the heating distribution of the fast reactor, a neutron-photon library in MATXS format named Knight-B7.1-1968n × 94γ was processed based on the ENDF/B-VII.1 library for ultrafine groups. The neutron cross-section processing code MGGC2.0 was used to generate few-group neutron cross sections in ISOTXS format. Additionally, the self-developed photon cross-section processing code NGAMMA was utilized to generate photon libraries for neutron-photon coupled heating calculations, including photo-atom cross sections for the ISOTXS format, prompt photon production cross sections, and kinetic energy release in materials (KERMA) factors for neutrons and photons, and the self-shielding effect from the capture and fission cross sections of neutron to photon have been taken into account when the photon source generated by neutron is calculated. The interface code GSORCAL was developed to generate the photon source distribution and interface with the DIF3D code to calculate the neutron-photon coupling heating distribution of the fast reactor core. The neutron-photon coupled heating calculation route was verified using the ZPPR-9 benchmark and the RBEC-M benchmark, and the results of the coupled heating calculations were analyzed in comparison with those obtained from the Monte Carlo code MCNP. The calculations show that the library was accurately processed, and the results of the fast reactor neutron-photon coupled heating calculations agree well with those obtained from MCNP.
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Qiwen Wu,Zhili Li,Guanqun Zhang,Jianqiang Niu,Xiduo Zeng,Baoli Sun,Jingyun Ma 대한수의학회 2017 Journal of Veterinary Science Vol.18 No.3
Porcine reproductive and respiratory syndrome virus (PRRSV) has a high degree of genetic variation. In this study, we characterized the genetic variation and evolutionary relationships among circulating PRRSV strains in southern China. We analyzed 29 NSP2 strains and 150 ORF5 strains from clinical samples collected in southern China during 2007–2014. The alignment results showed that the nucleotide identity similarities of the two genes among these strains were 80.5%–99.7% and 80.9%–100%, respectively. Phylogenetic analysis based on the NSP2 gene showed that highly pathogenic (HP)-PRRSV was still the dominant virus in southern China from 2013 to 2014. Compared with reference strains CH-1a and VR-2332, the field strain 131101-GD-SHC, which shared high homology with JXA1-P170, had a novel 12 amino acid deletion at position 499-510. Phylogenetic analysis based on the ORF5 gene showed that HP-PRRSV, VR2332-like strains, and QYYZ-like strains were simultaneously circulating in southern China from 2007 to 2014, suggesting that, in recent years, the type 2 PRRSV was more diverse in southern China. In conclusion, mutations in the decoy epitope and primary neutralizing epitope could be markers of viral evolution and used to study evolutionary relationships among PRRSV strains in China.
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Jindai Fan,Xiduo Zeng,Guanqun Zhang,Qiwen Wu,Jianqiang Niu,Baoli Sun,Qingmei Xie,Jingyun Ma 대한수의학회 2016 Journal of Veterinary Science Vol.17 No.3
Outbreaks of pseudorabies (PR) have occurred in southern China since late 2011, resulting in significant economic impacts on the swine industry. To identify the cause of PR outbreaks, especially among vaccinated pigs, 11 pseudorabies virus (PRV) field strains were isolated from Guangdong province during 2013–2014. Their major viral genes (gE, TK, gI, PK, gD, 11K, and 28K) were analyzed in this study. Insertions or deletions were observed in gD, gE, gI and PK genes compared with other PRV isolates from all over the world. Furthermore, sequence alignment showed that insertions in gD and gE were unique molecular characteristics of the new prevalent PRV strains in China. Phylogenetic analysis showed that our isolates were clustered in an independent branch together with other strains isolated from China in recent years, and that they showed a closer genetic relationship with earlier isolates from Asia. Our results suggest that these isolates are novel PRV variants with unique molecular signatures.
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Xiaoya Zhao,Zhili Li,Xiduo Zeng,Guanqun Zhang,Jianqiang Niu,Baoli Sun,Jingyun Ma 대한수의학회 2017 Journal of Veterinary Science Vol.18 No.2
The spike gene of porcine epidemic diarrhea virus (PEDV) was sequenced from 55 South China field strains isolated from pigs with symptoms of diarrhea. The sequences were compared within the set of field strains as well as with reference strains available in GenBank. Within the 55 South China PEDV field strains, the deduced amino acid sequence identities ranged from 93.8% to 99.9 % and ranged from 90.7% to 99.5% when compared with the foreign reference strains in GenBank. Our phylogenetic analysis showed that 10 of the 55 South China PEDV strains belonged to G1b and 45 belonged to G2b.
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