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RISS 인기검색어
- 검색키워드
- 저자 : Gargi Mishra (검색결과 4 건)
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Sensory nerve and neuropeptide diversity in adipose tissues
Gargi Mishra,Kristy L. Townsend Korean Society for Molecular and Cellular Biology 2024 Molecules and cells Vol.47 No.2
Both brown and white adipose tissues (BAT/WAT) are innervated by the peripheral nervous system, including efferent sympathetic nerves that communicate from the brain/central nervous system out to the tissue, and afferent sensory nerves that communicate from the tissue back to the brain and locally release neuropeptides to the tissue upon stimulation. This bidirectional neural communication is important for energy balance and metabolic control, as well as maintaining adipose tissue health through processes like browning (development of metabolically healthy brown adipocytes in WAT), thermogenesis, lipolysis, and adipogenesis. Decades of sensory nerve denervation studies have demonstrated the particular importance of adipose sensory nerves for brown adipose tissue and WAT functions, but far less is known about the tissue's sensory innervation compared to the better-studied sympathetic nerves and their neurotransmitter norepinephrine. In this review, we cover what is known and not yet known about sensory nerve activities in adipose, focusing on their effector neuropeptide actions in the tissue.
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Metabolic Engineering of Bacteria for Renewable Bioethanol Production from Cellulosic Biomass
Sanchita Banerjee,Gargi Mishra,Amit Roy 한국생물공학회 2019 Biotechnology and Bioprocess Engineering Vol.24 No.5
Biomass is renewable and most abundant raw material on earth. Technologies have been employed to utilize this vast renewable resource for biofuel production. In recent years, microorganisms have received much attention for biofuel production so that it can replace the non-renewable fossil fuels. They secrete synergistic enzymes for degrading the complex biomass to simple sugars and subsequently fermenting them to alcohol. With the help of recombinant DNA technology and other metabolic engineering, biomass metabolizing enzymes and bioethanol producing microbes have been developed which have been used as consolidated bioprocessing (CBP) reactors. In CBP, both hydrolysis and fermentation are carried out in a single reaction vessel. This review focuses on the recent achievements that have been made in some important industrial bacteria so that they are better capable of scavenging the biomass for bioethanol production. We have concentrated on introduction of heterologous genes and modifications of metabolic pathways in these microbes so that they can ferment a wide variety of sugars and at the same time can overcome the major challenges faced by them during ethanol production.
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Sensory nerve and neuropeptide diversity in adipose tissues
Kristy L. Townsend,Gargi Mishra 한국분자세포생물학회 2024 Molecules and cells Vol.47 No.1
Both brown and white adipose tissues (BAT/WAT) are innervated by the peripheral nervous system, including efferent sympathetic nerves that communicate from the brain/central nervous system out to the tissue, and afferent sensory nerves thatcommunicate from the tissue back to the brain and locally release neuropeptides to the tissue upon stimulation. This bidirectional neural communication is important for energy balance and metabolic control, as well as maintaining adipose tissue healththrough processes like browning (development of metabolically healthy brown adipocytes in WAT), thermogenesis, lipolysis,and adipogenesis. Decades of sensory nerve denervation studies have demonstrated the particular importance of adiposesensory nerves for brown adipose tissue and WAT functions, but far less is known about the tissue’s sensory innervationcompared to the better-studied sympathetic nerves and their neurotransmitter norepinephrine. In this review, we cover what isknown and not yet known about sensory nerve activities in adipose, focusing on their effector neuropeptide actions in the tissue.
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