http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Ga-Yeong Kim,Hee-Ryoung Cha,Youn-Kyoung Baek,Young-Kuk Kim,Dong-Hwan Kim,Yang-Do Kim,Jung-Goo Lee 한국자기학회 2020 Journal of Magnetics Vol.25 No.2
Nd in hot-deformed Nd-Fe-B magnets was partially substituted by Ce and La for the purpose of reducing the materials cost and balancing the utilization of rare earth resources. Initial melt-spun ribbons with the nominal compositions of (Nd1-xMx)13.6FebalB5.6Ga0.6Co6.6 (x = 0, x = 0.2/M=Ce, x = 0.3/M=Ce, Ce+La, wt.%) were prepared by a single-roller melt-spinning method, and pulverized into powders. The powders were then hot-pressed at 973 K under 100 MPa, and deformed at 973 K until 75 % of height reduction was achieved. The magnetic properties of hot-deformed magnets were decreased with the substitution of Ce for Nd. In addition, simultaneous substitution of Ce and La for Nd resulted in much lower magnetic properties. This tendency was almost the same as initial melt-spun powders. The deterioration on magnetic properties by substation of Ce and La for Nd in hot-deformed Nd-Fe-B magnets could be attributed to not only inferior intrinsic properties of (Ce/La)₂Fe14B to Nd₂Fe14B phase but also the effect of Ce/La substitution on microstructure such as density and grain alignment during hot-deformation. Although the magnetic properties were deteriorated by substitution of Ce and La for Nd in hot-deformed Nd-Fe-B magnets, the cost performance was largely enhanced from 2.32 to 2.62 MGOe×kg/$ by 13 % when increasing the content of Ce substituted for Nd from 0 to 0.3 wt.%.
Existence of glioma stroma mesenchymal stemlike cells in Korean glioma specimens.
Kim, Young Goo,Jeon, Soyoun,Sin, Ga-Yeong,Shim, Jin-Kyoung,Kim, Bo-Kyung,Shin, Hye-Jin,Lee, Ji-Hyun,Huh, Yong-Min,Lee, Su-Jae,Kim, Eui-Hyun,Park, Eun Kyung,Kim, Se-Hoon,Chang, Jong Hee,Kim, Dong Seok Springer Verlag 2013 Child’s nervous system Vol.29 No.4
<P>It was presented that mesenchymal stem cells (MSCs) can be isolated from western glioma specimens. However, whether MSCs exist in glioma specimens of different ethnicities is unknown. To verify the existence of MSCs in an independent cohort, we undertook studies to isolate MSCs from a group of Korean patients. We hypothesized that cells resembling MSCs that were deemed mesenchymal stemlike cells (MSLCs) exist in an independent cohort of Korean gliomas. We cultured fresh glioma specimens using the protocols used for culturing MSCs. The cultured cells were analyzed with fluorescence-activated cell sorting (FACS) for surface markers associated with MSCs. Cultured cells were exposed to mesenchymal differentiation conditions. To presume possible locations of MSLCs in the glioma, sections of glioma were analyzed by immunofluorescent labeling for CD105, CD31, and NG2. From nine of 31 glioma specimens, we isolated cells resembling MSCs, which were deemed Korean glioma stroma MSLCs (KGS-MSLCs). KGS-MSLCs were spindle shaped and adherent to plastic. KGS-MSLCs had similar surface markers to MSCs (CD105(+), CD90(+), CD73(+), and CD45(-)). KGS-MSLCs were capable of mesenchymal differentiation and might be located around endothelial cells, pericytes, and in a disorganized perivascular area inside glioma stroma. We found that cells resembling MSCs indeed exist in an independent cohort of glioma patients, as presented in western populations. We could presume that the possible location of KGS-MSLCs was in perivascular area or in glioma stroma that was a disorganized vascular niche. It might be possible that KGS-MSLCs could be one of constituent of stroma of glioma microenvironment.</P>
Kim, Rae-Kwon,Kim, Min-Jung,Yoon, Chang-Hwan,Lim, Eun-Jung,Yoo, Ki-Chun,Lee, Ga-Haeng,Kim, Young-Heon,Kim, Hyeonmi,Jin, Yeung Bae,Lee, Yoon-Jin,Cho, Cheon-Gyu,Oh, Yeong Seok,Gye, Myung Chan,Suh, Yongj American Society for Pharmacology and Experimental 2012 Molecular pharmacology Vol.82 No.3
<P>Glioma cells with stem cell properties, termed glioma stem-like cells (GSCs), have been linked to tumor formation, maintenance, and progression and are responsible for the failure of chemotherapy and radiotherapy. Because conventional glioma treatments often fail to eliminate GSCs completely, residual surviving GSCs are able to repopulate the tumor. Compounds that target GSCs might be helpful in overcoming resistance to anticancer treatments in human brain tumors. In this study, we showed that 5-bromo-3-(3-hydroxyprop-1-ynyl)-2H-pyran-2-one (BHP), a new 2-pyrone derivative, suppressed the maintenance of the GSC population in both a glioma cell line and patient-derived glioma cells. Treatment of GSCs with BHP effectively inhibited sphere formation and suppressed the CD133(+) cell population. Treatment with BHP also suppressed expression of the stemness-regulating transcription factors Sox2, Notch2, and β-catenin in sphere-cultured glioma cells. Treatment of GSCs with BHP significantly suppressed two fundamental characteristics of cancer stem cells: self-renewal and tumorigenicity. BHP treatment dramatically inhibited clone-forming ability at the single-cell level and suppressed in vivo tumor formation. BHP markedly inhibited both phosphoinositide 3-kinase/Akt and Ras/Raf-1/extracellular signal-regulated kinase signaling, which suggests that one or both of these pathways are involved in BHP-induced suppression of GSCs. In addition, treatment with BHP effectively sensitized GSCs to chemotherapy and radiotherapy. Taken together, these results indicate that BHP targets GSCs and enhances their sensitivity to anticancer treatments and suggest that BHP treatment may be useful for treating brain tumors by eliminating GSCs.</P>
Kim, Ga Ram,Hur, Jin,Lee, Hye-Jeong,Nam, Ji Eun,Kim, Young Jin,Hong, Yoo Jin,Shim, Hyo Sup,Kim, Hee Yeong,Lee, Ji Won,Choi, Byoung Wook The American Cancer Society by Liss-Wiley, a subsi 2013 Cancer cytopathology Vol.121 No.4
<P>The purpose of this study was to assess whether analyses of tumor markers in cytological fluid can improve the performance of computed tomography (CT)-guided needle aspiration biopsy (NAB) for the diagnosis of ground-glass opacity (GGO) pulmonary lesions.</P>