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Yang Feng,Zhiming Fu,Yajun Luo,Wang Tan,Zilin Liu,Pengcheng Ye,Fei Lu,Wanping Xiang,Linghan Tang,Lin Yao,Mengyun Song,Qingmei Huang,Yilun Liu,Jiangwei Xiao 대한독성 유전단백체 학회 2019 Molecular & cellular toxicology Vol.15 No.3
Backgrounds: The role of long non-coding RNAs (lncRNA) in gastric cancer (GC) has been highlighted in studies conducted over the past decade. However, the potential clinical value and the mechanisms of action of RP11-6O2.4 in GC have not been thoroughly elucidated to date. The specific aim of the present study was to assess RP11-6O2.4 and to explore its role in human GC. Methods: Quantitative real-time polymerase chain reaction (qPCR) was performed to analyze the expression levels of RP11-6O2.4 in GC tissues, paired adjacent noncancerous tissues (ANTs) and GC cell lines. In addition, the correlation between RP11-6O2.4 expression and the clinical characteristics and prognosis of patients with GC was statistically analyzed. The effects of RP11- 6O2.4 on the GC cell cycle transformation through the p38-MAPK signaling pathway were explored by flow cytometry, qPCR and Western blot analysis after treatment with SB203580, a p38MAPK specific inhibitor, in vitro. Results: The expression levels of RP11-6O2.4 in GC tissues were significantly lower than the paired ANTs (P<0.05). In addition, RP11-6O2.4 expression was significantly lower in cases with older age, longer maximum tumor diameter, higher ASA grade and deeper invasive depth (P<0.05). RP11-6O2.4 expression was significantly higher in cases with well/middle differentiation than poor/no differentiation; higher in cases without lymph node metastasis than in lymph node metastasis; and higher in cases in stage Ⅰ/Ⅱ than in stage Ⅲ/Ⅳ. An in vitro assay showed that RP11-6O2.4 induced G0/ G1 phase cell cycle arrest, likely by regulating the p38- MAPK signaling pathway. Conclusion: The above mentioned data suggested that RP11-6O2.4 was a tumor-suppressor gene in GC. RP11- 6O2.4 might play an important role in the cell cycle transformation by regulating the p38-MAPK signaling pathway, thereby representing a specific biomarker and a potential molecular target for the treatment of GC.
Xiang, Jing,Yang, Tian-Tian,Fu, Lu-Lu,Luo, Ya,Wu, Jia-Shou Korean Chemical Society 2013 Bulletin of the Korean Chemical Society Vol.34 No.9
The reactions of hydrated $CdCl_2$, $MnCl_2$, and $NiCl_2$ with 2,2'-bipyidine-3,3',6,6'-tetracarboxylic acid ($H_4bptc$) afforded the mononuclear [$Cd^{II}(H_2bptc)(H_2O)_3]{\cdot}H_2O$ (1), linear $\{[Cd(H_2bptc)(H_2O)]{\cdot}3H_2O\}_n$ (2), 3-D heterobimetallic $[NaCd(Hbptc)(H_2O)]$ (3), layer $[Mn(H_2bptc)(H_2O)]_n$ (4) and a dinuclear compound $[Ni_2(H_2bptc)-(H_2O)_2]{\cdot}6H_2O$ (5). These compounds have been characterized by elemental analysis, IR, and their structures have been determined by X-ray crystallography. The thermal stabilities of 1-3 were measured by thermogravimetric analysis (TGA) and their solid state luminescence properties together with the free ligand $H_4bptc$ were investigated at room temperature.
XIANG-YU MENG,ZE-WEI BAO,FU-SHENG YANG,ZAO-XIAO ZHANG 대한설비공학회 2011 International Journal Of Air-Conditioning and Refr Vol.19 No.2
A solar energy storage system based on metal hydrides was proposed in this paper. The numerical simulation of processes of energy storage and thermal release were carried out. The dynamic behavior of heat and mass transfer in the metal hydride energy system were reported. Some factors which influence the whole system performance were discussed. The paper also made an economic analysis of the system, the results proved that the large amounts of metal hydride materials and the configurations of metal hydrides energy storage system involve a critical situation from an economical point of view. Then further analysis, particularly regarding the performance optimization and new plant arrangement of the metal hydrides energy storage system, has to be developed in order to attain the economical feasibility of the proposal.
ACCRETION-JET MODEL FOR THE HARD X-ray Γ - L<sub>X</sub> CORRELATION IN BLACK HOLE X-ray BINARIES
YANG, QI-XIANG,XIE, FU-GUO,YUAN, FENG,ZDZIARSKI, ANDRZEJ A.,GIERLINSKI, MAREK,HO, LUIS C.,YU, ZHAOLONG The Korean Astronomical Society 2015 天文學論叢 Vol.30 No.2
In this work, we study the correlation between the photon index (${\Gamma}$) of the X-ray spectrum and the 2-10 keV X-ray luminosity ($L_X$) for black hole X-ray binaries (BHBs). The BHB sample is mainly from the quiescent, hard and intermediate states, with values of $L_X$ ranging from ${\sim}10^{30.5}$ to $10^{37.5}$ erg $s^{-1}$. We find that the photon index ${\Gamma}$ is positively or negatively correlated with the X-ray luminosity $L_X$, for $L_X$ above or below a critical value, ${\sim}10^{36.5}$ erg $s^{-1}$. This result is consistent with previous works. Moreover, when $L_X{\leq}{\sim}10^{33}$ erg $s^{-1}$, we found that the photon index is roughly independent of the X-ray luminosity. We interpret the above correlations in the framework of a coupled hot accretion flow - jet model. Besides, we also find that in the moderate-luminosity region, different sources may have different anti-correlation slopes, and we argue this diversity is caused by the different value of ${\delta}$, which describes the fraction of turbulent dissipation that directly heats electrons.
Fu-hua Lin,Bo Wang,Shuang-dan Mao,Xiang-yang Li,Yu-ying Zhao,Ying-Hui Wei 한국고분자학회 2021 폴리머 Vol.45 No.5
The microcrystalline cellulose (MCC) was used for inducing crystallization of the isotactic polybutene-1 (iPB) and the maleic anhydride grafted polybutene-1 (MAPB) was used as a compatibilizer. The crystallization behavior of the composite demonstrated that the addition of MCC could significantly accelerate the crystallization rate of iPB and the addition of MAPB could improve the compatibility between MCC and iPB. Moreover, the properties of the composites with MAPB were better than those without MAPB. The crystal transformation had been completed after storage for 5 days and the form I was formed after storage for 3 days which was faster than pure iPB. The non-isothermal crystallization kinetics data of the composites indicated that the modified Avrami equation could describe the non-isothermal crystallization process of the iPB/MCC composite and the t1/2 of the composites was shortened for 24.32% and 40.27% which indicated that MCC could promote the crystallization of iPB.
Yang, Zhen,Liu, Hong-Xiang,Zhang, Xie-Fu Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.5
Background: Studies investigating the association between 2R/3R polymorphisms in the thymidylate synthase 5'-untranslated enhanced region (TYMS 5'-UTR) and gastric cancer risk have generated conflicting results. Thus, a meta-analysis was performed to summarize the data on any association. Methods: Pubmed, Embase, and CNKI databases were searched for all available studies. The strength of association between TYMS 5'-UTR 2R/3R polymorphism and gastric cancer risk was estimated by odds ratios (ORs) with 95% confidence intervals (CIs). Results: Six individual case-control studies with a total of 1, 472 cases and 1, 895 controls were included into this meta-analysis. Analyses of total six relevant studies showed that there was no obvious association between the TYMS 5'-UTR 2R/3R polymorphism and gastric cancer risk. Subgroup analyses based on ethnicity showed 2R of TYMS 5'-UTR 2R/3R contributes to gastric cancer risk in the Asian population ($OR_{Homozygote\;model}$ = 1.71, 95%CI 1.19-2.46, P = 0.004; $OR_{Recessive\;genetic\;model}$ = 1.70, 95%CI 1.18-2.43, P = 0.004). However, the association in Caucasian populations was uncertain due to the limited studies. Conclusions: Our meta-analysis suggests that 2R of TYMS 5'-UTR 2R/3R contributes to gastric cancer risk in the Asian population, while this association in Caucasians populations needs further study.
MTHFR C677T Polymorphism and Colorectal Cancer Risk in Asians, a Meta-analysis of 21 Studies
Yang, Zhen,Zhang, Xie-Fu,Liu, Hong-Xiang,Hao, Yong-Shun,Zhao, Chun-Lin Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.4
Background: Previous studies concerning the association between methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and colorectal cancer risk in Asian populations generated conflicting results. A meta-analysis was therefore performed to allow a more reliable estimate of any link. Methods: Relevant studies concerning the association between the MTHFR C677T polymorphism and risk of colorectal cancer were included into this meta-analysis. The quality of the studies was assessed according to a predefined scale. Odds ratios (ORs) and 95% confidence intervals (CIs) were determined for this gene-disease association using fixed or random effect models according to the heterogeneity between included studies. Results: Finally, 21 studies with a total of 6692 cases and 8266 controls were included. Meta-analyses showed that there was an obvious association of the MTHFR 677T allele with decreased risk of colorectal cancer (OR = 0.91, 95%CI=0.85-0.98, P=0.011). Subgroup analyses by country further identified this association, with dietary folate as the main source of heterogeneity. Conclusion: The MTHFR 677T allele is associated with a lower risk of colorectal cancer in Asian populations, and there is effect modification by population plasma folate.
Role of miR-511 in the Regulation of OATP1B1 Expression by Free Fatty Acid
( Jin Fu Peng ),( Li Liu ),( Cheng Xian Guo ),( Shi Kun Liu ),( Xiao Ping Chen ),( Li Hua Huang ),( Hong Xiang ),( Zhi Jun Huang ),( Hong Yuan ),( Guo Ping Yang ) 한국응용약물학회 2015 Biomolecules & Therapeutics(구 응용약물학회지) Vol.23 No.5
MicroRNAs (miRNAs) are a family of non-coding RNA that are able to adjust the expression of many proteins, including ATPbinding cassette transporter and organic cation transporter. We sought to evaluate the effect of miR-511 on the regulation of OATP1B1 expression by free fatty acids. When using free fatty acids to stimulate Chang liver cells, we found that the expression of miR-511 increased significantly while the expression of OATP1B1 decreased. We also proved that SLCO1B1 is the target gene of miR-511 with a bioinformatics analysis and using the dual luciferase reporter assay. Furthermore, the expressions of SLCO1B1 and OATP1B1 decreased if transfecting Chang liver cells with miR-511, but did not increase when transfecting the inhibitors of miR-511 into steatosis cells. Our study indicates that miR-511 may play an important role in the regulation of OATP1B1 expression by free fatty acids.