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RISS 인기검색어
- 검색키워드
- 저자 : Francesco Epifano (검색결과 4 건)
- 무료
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Phytochemical Investigation on Leaf Extract of Cordia salicifolia Cham.
Luigi Menghini,Francesco Epifano,Lidia Leporini,Rita Pagiotti,Bruno Tirillini 한국식품영양과학회 2008 Journal of medicinal food Vol.11 No.1
The dichloromethane extract of leaves of Cordia salicifoliaCham. (Family Boraginaceae) was fractionated bySiO2 column chromatography and analyzed by gas chromatography, gas chromatography-mass spectrometry, and nuclear mag-netic resonance spectroscopy. The apolar extract is characterized by a very high content of (. )-spathulenol (0.53%). The ma-jor component of the extract exhibited a very weak activity as an inhibitor of growth of Helicobacter pylori in vitro(mini-mum inhibitory concentration. 200 .g/mL).
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Luigi Menghini,Lidia Leporini,Bruno Tirillini,Francesco Epifano,Salvatore Genovese 한국식품영양과학회 2010 Journal of medicinal food Vol.13 No.1
The chemical composition of the essential oil obtained from Apium nodiflorum (L.) Lag. (Family Apiaceae), a plant used in the ethnomedical traditions of the Abruzzo region (Central Italy) as a culinary herb, as a diuretic, and to cure stomachache, was analyzed by gas chromatography/mass spectrometry, and 14 components were identified. Limonene (27.72 %), p-cymene (23.06%), myristicine (18.51%), and β-pinene (6.62%) were the main components. The antimicrobial activity of the essential oil was assayed in vitro against Helicobacter pylori (strain DSMZ 4867), resulting in a minimum inhibitory concentration value of 12.5μg/mL.
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Anti-Inflammatory and Wound Healing Potential of Citrus Auraptene
Vu Dang La,Lei Zhao,Francesco Epifano,Salvatore Genovese,Daniel Grenier 한국식품영양과학회 2013 Journal of medicinal food Vol.16 No.10
Auraptene is the most abundant naturally occurring geranyloxycoumarin. It is primarily isolated from plants in the Rutaceae family, many of which, like citrus fruits, are used as food in many countries. Auraptene is a biologically active secondary metabolite with valuable properties. The aim of our study was to identify novel properties of auraptene with potential for managing periodontal diseases, an inflammatory disease of bacterial origin affecting the tissues surrounding and supporting the teeth. In vitro assays showed that auraptene decreased, in a dose-dependent manner, the secretion of matrix metalloproteinase 2 as well as key inflammatory mediators, including interleukin-6 (IL-6), IL-8, and chemokine (C-C motif) ligand-5 secreted by Aggregatibacter actinomycetemcomitans lipopolysaccharide-stimulated oral epithelial cells. Using gingival fibroblasts, auraptene showed a significant (P < .05) wound healing effect by its capacity to increase cell migration. In conclusion, auraptene shows promise for promoting wound healing and controlling periodontal diseases through its capacity to interfere with inflammatory mediator secretion.
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Antioxidant Effects of Garlic in Young and Aged Rat Brain In Vitro
Luigi Brunetti,Luigi Menghini,Giustino Orlando,Lucia Recinella,Sheila Leone,Francesco Epifano,Francesco Lazzarin,Annalisa Chiavaroli,Claudio Ferrante,Michele Vacca 한국식품영양과학회 2009 Journal of medicinal food Vol.12 No.5
Oxidative stress plays a key role in the pathogenesis of age-related neurodegeneration, and the nonenzymatic production of 8-iso-prostaglandin F2α (8-iso-PGF2α) may represent a reliable index of cellular oxidative damage. Garlic (Allium sativum) has been associated with peripheral antioxidant activities and therefore might prevent or reverse 8-iso-PGF2α production, but scant data are available on its possible neuroprotective effects. Therefore, we have studied the possible antioxidant effects of a garlic extract in rat brain synaptosomes obtained from young (3-month-old) and aged (14-month-old) male Wistar rats that were perfused, in vitro, with graded concentrations of a garlic extract (10–500μg/mL). Release in the effluent was evaluated, both in the basal state and after hydrogen peroxide-induced oxidative stress. In young rats, we observed a concentration-dependent inhibitory effect of the garlic extract on brain 8-iso-PGF2α production, both basally and after hydrogen peroxide-induced oxidative stimulus. In aged rats, 8-iso-PGF2α production was not affected by the garlic extract in the basal state, whereas, after hydrogen peroxide-induced oxidative stimulus, an antioxidant effect of the garlic extract appeared only at the higher concentration tested. In conclusion, garlic supplementation could be effective in preventing brain oxidative damage in young animals, whereas the aging brain seems to be resistant to the antioxidant effects of garlic, in vitro.
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