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- 저자 : Fengyun Hao (검색결과 2 건)
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Zhang WenXin,Li Hao,Cong Haofei,Zhou Ruifu,Qin Yuanbin,Xu Peilong,Liu Xuhai,Wang Fengyun 한국물리학회 2023 Current Applied Physics Vol.48 No.-
One-dimensional wide band-gap metal oxide semiconductors demonstrate enormous potential in high-performance ultraviolet photodetectors. Here, via tuned zinc oxide (ZnO) concentration ratio and heterojunction structure as well as decent VTH value, we electrospun tin zinc oxide (SnZnOX) nanowires for photoelectronic conversion function. The constructed optimized photodetectors based on Sn8Zn2OX nanowires can exhibit a remarkable detectivity of 1.77 × 1016 Jones, excellent responsivity of 2.23 × 103 A/W and relative high sensitivity over 104. In addition to the excellent photodetection performance, Sn8Zn2OX nanowire devices exhibit nonvolatile memory effect, which can maintain the light-induced low resistance state at 5 V without light. Moreover, a voltage of 30 V was applied to Sn8Zn2OX nanowires devices to realize light-writing state switching to bias-erasing state, and the device could come back to their initial high resistance state. These results indicate SnZnOX nanowires devices possess a tremendous potential in the circuit design of the artificial visual system.
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Correlation of NUF2 Overexpression with Poorer Patient Survival in Multiple Cancers
Xiaodan Jiang,Yan Jiang,Senbiao Luo,Karthik Sekar,Clara Kai Ting Koh,Amudha Deivasigamani,Qingzhe Dong,Niankai Zhang,Shenling Li,Fengyun Hao,Brian Kim Poh Goh,London Lucien Ooi,Yu Wang,Kam Man Hui 대한암학회 2021 Cancer Research and Treatment Vol.53 No.4
Purpose NUF2 has been implicated in multiple cancers recently, suggesting NUF2 may play a role in the common tumorigenesis process. In this study, we aim to perform comprehensive meta-analysis of NUF2 expression in the cancer types included in the Cancer Genome Atlas (TCGA). Materials and Methods RNA-sequencing data in 31 cancer types in the TCGA data and 11 independent datasets were used to examine NUF2 expression. Silencing NUF2 using targeting shRNAs in hepatocellular carcinoma (HCC) cell lines was used to evaluate NUF2’s role in HCC in vitro and in vivo. Results NUF2 up-regulation is significantly observed in 23 out of the 31 cancer types in the TCGA datasets and validated in 13 major cancer types using 11 independent datasets. NUF2 overexpression was clinically important as high NUF2 was significantly associated with tumor stages in eight different cancers. High NUF2 was also associated with significantly poorer patient overall survival and disease-free survival in eight and six cancers, respectively. We proceeded to validate NUF2 overexpression and its negative association with overall survival at the protein level in an independent cohort of 40 HCC patients. Compared to the non-targeting controls, NUF2 knockdown cells showed significantly reduced ability to grow, migrate into a scratch wound and invade the 8 μm porous membrane in vitro. Moreover, NUF2 knockdown cells also formed significantly smaller tumors than control cells in mouse xenograft assays in vivo. Conclusion NUF2 up-regulation is a common feature of many cancers. The prognostic potential and functional impact of NUF2 up-regulation warrant further studies.
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