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An optimization framework to tackle challenging cargo accommodation tasks in space engineering
Fasano, Giorgio,Gastaldi, Cristina,Piras, Annamaria,Saia, Dario Techno-Press 2014 Advances in aircraft and spacecraft science Vol.1 No.2
Quite a demanding task frequently arises in space engineering, when dealing with the cargo accommodation of modules and vehicles. The objective of this effort usually aims at maximizing the loaded cargo, or, at least, at meeting the logistic requirements posed by the space agencies. Complex accommodation rules are supposed to be taken into account, in compliance with strict balancing conditions and very tight operational restrictions. The context of the International Space Station (ISS) has paved the way for a relevant research and development activity, providing the company with a remarkable expertise in the field. CAST (Cargo Accommodation Support Tool) is a dedicated in-house software package (funded by the European Space Agency, ESA, and achieved by Thales Alenia Space), to carry out the whole loading of the Automated Transfer Vehicle (ATV). An ad hoc version, tailored to the Columbus (ISS attached laboratory) on-board stowage issue, has been further implemented and is to be used from now on. This article surveys the overall approach followed, highlighting the advantages of the methodology put forward, both in terms of solution quality and time saving, through an overview of the outcomes obtained to date. Insights on possible extensions to further space applications, especially in the perspective of the paramount challenges of the near future, are, in addition, presented.
Pallidal Deep Brain Stimulation for Refractory Celiac-Related Myoclonus
Jinyoung Youn,Alfonso Fasano 대한파킨슨병및이상운동질환학회 2023 Journal Of Movement Disorders Vol.16 No.3
Gluten-related disorders are a broad spectrum of immunemediated disorders, and celiac disease (CD) is the most common and well-known among these disorders. CD can present with various neurological issues, with ataxia being the most common neurological symptom and myoclonus being the most common movement disorder after ataxia
TNR Gene Mutation in Familial Parkinson’s Disease: Possible Implications for Essential Tremor
Michel Sáenz-Farret,Renato Puppi Munhoz,Alfonso Fasano,Carlos Zúñiga-Ramírez 대한파킨슨병및이상운동질환학회 2021 Journal Of Movement Disorders Vol.14 No.2
Farlow et al.1 reported in 2016 new rare tyrosine kinase nonreceptor2 and tenascin R (TNK2 and TNR, respectively) variantsassociated with the development of Parkinson’s disease(PD). No detailed clinical information about such patients orother reports is available thus far. We report a subject with PDand two of his sons with essential tremor (ET) harboring a TNRgene mutation.
Davide Di Mauro,Mariannita Gelsomino,Angelica Fasano,Shahjehan Wajed,Antonio Manzelli 한국간담췌외과학회 2022 Annals of hepato-biliary-pancreatic surgery Vol.26 No.2
Backgrounds/Aims: Splenectomy in patients with non-Hodgkin lymphoma (NHL) is performed to relieve abdominal symptoms, treat hypersplenism or confirm diagnosis. Excision of a very large spleen is technically challenging and data on outcomes of surgery in patients with NHL are scanty. The aim of study was to evaluate the impact of spleen size on the surgical outcome of splenectomy in patients with NHL. Methods: Patients with NHL who underwent splenectomy, between 2006 and 2017, were included and divided into two groups: group 1, spleen ≤ 20 cm; group 2, spleen > 20 cm. Surgical approach, operative time, postoperative morbidity, mortality, hospital stay and re-admission rates were retrospectively compared between groups. Non-parametric data were evaluated with the Mann-Whitney U test. Differences in frequencies were analyzed with Fisher’s exact test. Results: Sixteen patients were included (group 1, 6; group 2, 10). Laparoscopy was successful in three patients of group 1, none of group 2 (p = 0.035), the intraoperative time did not differ significantly between groups. One patient in each group developed postoperative complications. The patient in group 1 died of pneumonia. Median length of stay was 8 days (range, 3–16 days) for group 1, 5.5 days (range, 3–10 days) for group 2, showing no significant difference between the two groups. No patient was readmitted to hospital. Conclusions: Spleen size does not affect the outcome of splenectomy in patients with NHL. If a mini-invasive approach is to be chosen, laparoscopy may not be feasible when the spleen size is > 20 cm.
Update on Current Technologies for Deep Brain Stimulation in Parkinson’s Disease
Michelle Paff,Aaron Loh,Can Sarica,Andres M. Lozano,Alfonso Fasano 대한파킨슨병및이상운동질환학회 2020 Journal Of Movement Disorders Vol.13 No.3
Deep brain stimulation (DBS) is becoming increasingly central in the treatment of patients with Parkinson’s disease and other movement disorders. Recent developments in DBS lead and implantable pulse generator design provide increased flexibility for programming, potentially improving the therapeutic benefit of stimulation. Directional DBS leads may increase the therapeutic window of stimulation by providing a means of avoiding current spread to structures that might give rise to stimulation-related side effects. Similarly, control of current to individual contacts on a DBS lead allows for shaping of the electric field produced between multiple active contacts. The following review aims to describe the recent developments in DBS system technology and the features of each commercially available DBS system. The advantages of each system are reviewed, and general considerations for choosing the most appropriate system are discussed.
Faraday-Shielded dc Stark-Shift-Free Optical Lattice Clock
Beloy, K.,Zhang, X.,McGrew, W. F.,Hinkley, N.,Yoon, T. H.,Nicolodi, D.,Fasano, R. J.,Schä,ffer, S. A.,Brown, R. C.,Ludlow, A. D. American Physical Society 2018 Physical Review Letters Vol.120 No.18
<P>We demonstrate the absence of a dc Stark shift in an ytterbium optical lattice clock. Stray electric fields are suppressed through the introduction of an in-vacuum Faraday shield. Still, the effectiveness of the shielding must be experimentally assessed. Such diagnostics are accomplished by applying high voltage to six electrodes, which are grounded in normal operation to form part of the Faraday shield. Our measurements place a constraint on the dc Stark shift at the 10(-20) level, in units of the clock frequency. Moreover, we discuss a potential source of error in strategies to precisely measure or cancel nonzero dc Stark shifts, attributed to field gradients coupled with the finite spatial extent of the lattice-trapped atoms. With this consideration, we find that Faraday shielding, complemented with experimental validation, provides both a practically appealing and effective solution to the problem of dc Stark shifts in optical lattice clocks.</P>
GASP. I. Gas Stripping Phenomena in Galaxies with MUSE
Poggianti, Bianca M.,Moretti, Alessia,Gullieuszik, Marco,Fritz, Jacopo,Jaffé,, Yara,Bettoni, Daniela,Fasano, Giovanni,Bellhouse, Callum,Hau, George,Vulcani, Benedetta,Biviano, Andrea,Omizzolo, A American Astronomical Society 2017 The Astrophysical journal Vol.844 No.1
Bellhouse, C.,Jaffé,, Y. L.,Hau, G. K. T.,McGee, S. L.,Poggianti, B. M.,Moretti, A.,Gullieuszik, M.,Bettoni, D.,Fasano, G.,D’Onofrio, M.,Fritz, J.,Omizzolo, A.,Sheen, Y.-K.,Vulcani, B. American Astronomical Society 2017 The Astrophysical journal Vol.844 No.1
<P>This paper presents a spatially. resolved kinematic study of the jellyfish galaxy JO201, one of the most spectacular cases of ram-pressure stripping (RPS) in the. GAs Stripping Phenomena in galaxies with MUSE (GASP) survey. By studying the environment of JO201, we find that it is moving through the dense intracluster medium of Abell 85 at supersonic speeds along our line of sight, and that it is likely accompanied by a small group of galaxies. Given the density of the intracluster medium and the galaxy's mass, projected position, and velocity within the cluster, we estimate that JO201 must so far have lost similar to 50% of its gas during infall via RPS. The MUSE data indeed reveal a smooth stellar disk. accompanied by large projected tails of ionized (Ha) gas, composed of kinematically cold (velocity dispersion < 40 km s(-1)) star-forming knots and very warm (> 100 km s(-1)) diffuse emission,. that. extend out to at least similar to 50 kpc from the galaxy center. The ionized H alpha-emitting gas in the disk rotates with the stars out to similar to 6. kpc; but, in the disk outskirts,. it. becomes increasingly redshifted with respect to the (undisturbed) stellar disk. The observed disturbances are consistent with the presence of gas trailing behind the stellar component. resulting from intense face-on RPS. along the line of sight. Our kinematic analysis is consistent with the estimated fraction of lost gas. and reveals that stripping of the disk happens outside-in, causing shock heating and gas compression in the stripped tails.</P>